Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Janine Scholefield"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Human induced pluripotent stem cell-derived models are a well-established preclinical tool, with the ability to retain the genetics of the individual from which they are derived. Here we comment on the global representation and accessibility of such
Externí odkaz:
https://doaj.org/article/8524c9a9d87849718fcfc4b768ecfae8
Autor:
Shivani Goolab, Janine Scholefield
Publikováno v:
Frontiers in Genome Editing, Vol 6 (2024)
The designer nuclease, CRISPR-Cas9 system has advanced the field of genome engineering owing to its programmability and ease of use. The application of these molecular scissors for genome engineering earned the developing researchers the Nobel prize
Externí odkaz:
https://doaj.org/article/e4107a19580f44f5ad2ea4a586347f14
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103534- (2024)
The lack of equitable representation of African diversity in scientific resources, such as genome-wide association studies and human induced pluripotent stem cell (hiPSC) repositories, has perpetuated inequalities in the advancement of health researc
Externí odkaz:
https://doaj.org/article/16a617cb72494d95a2b0af4b34da9851
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Pharmaceuticals are indispensable to healthcare as the burgeoning global population is challenged by diseases. The African continent harbors unparalleled genetic diversity, yet remains largely underrepresented in pharmaceutical research and developme
Externí odkaz:
https://doaj.org/article/d6c3f24cac30430398948a727b523318
Autor:
Richard J Burman, Lauren M Watson, Danielle C Smith, Joseph V Raimondo, Robea Ballo, Janine Scholefield, Sally A Cowley, Matthew J A Wood, Susan H Kidson, Leslie J Greenberg
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247434 (2021)
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the ATXN7 gene. Patients with this disease suffer from a degeneration of their cerebellar Purkinje neurons and retinal photor
Externí odkaz:
https://doaj.org/article/d17f542b1879484485ae79adc792653e
Autor:
Janine Scholefield, Ricardo Henriques, Anca F. Savulescu, Elisabeth Fontan, Alix Boucharlat, Emmanuel Laplantine, Asma Smahi, Alain Israël, Fabrice Agou, Musa M. Mhlanga
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
NEMO is a member of the IKK complex that binds ubiquitin, involved in NF-κB signalling and proposed to form higher order structures. Here the authors use super-resolution microscopy to detect the presence of NEMO lattices in cells, that are modified
Externí odkaz:
https://doaj.org/article/bf1e75c472b84f6aaf2453cc4cab9d72
Autor:
Samantha Barichievy, Jerolen Naidoo, Mikaël Boullé, Janine Scholefield, Suraj P. Parihar, Anna K. Coussens, Frank Brombacher, Alex Sigal, Musa M. Mhlanga
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
An emerging realization of infectious disease is that pathogens can cause a high incidence of genetic instability within the host as a result of infection-induced DNA lesions. These often lead to classical hallmarks of cancer, one of which is the abi
Externí odkaz:
https://doaj.org/article/44491a2a7efe42fbaddf1e2d9ebe9cba
Autor:
Janine Scholefield, L Jacquie Greenberg, Marc S Weinberg, Patrick B Arbuthnot, Amr Abdelgany, Matthew J A Wood
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7232 (2009)
Spinocerebellar ataxia type 7 is a polyglutamine disorder caused by an expanded CAG repeat mutation that results in neurodegeneration. Since no treatment exists for this chronic disease, novel therapies such post-transcriptional RNA interference-base
Externí odkaz:
https://doaj.org/article/ebe8360bd17444879e1c34686c2724c4
Publikováno v:
Gene Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa4b795d7784bd53f14052ffa20b6e1
https://doi.org/10.1038/s41434-021-00263-9
https://doi.org/10.1038/s41434-021-00263-9
Autor:
Janine Scholefield
Publikováno v:
Gene Therapy. 28:1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c5783b9b53b54bcc5b3a107cc2734e
https://doi.org/10.1038/s41434-020-00188-9
https://doi.org/10.1038/s41434-020-00188-9