Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Janine P. Wereley"'
Autor:
Christopher R. Chitambar, John S. Kuo, Kimberly R. Pechman, Mona M. Al-Gizawiy, Hisham S. Alhajala, William E. Antholine, Janine P. Wereley, Kathleen M. Schmainda, Paul A. Clark, Robert Wujek
Publikováno v:
Molecular Cancer Therapeutics. 17:1240-1250
Gallium, a metal with antineoplastic activity, binds transferrin (Tf) and enters tumor cells via Tf receptor1 (TfR1); it disrupts iron homeostasis leading to cell death. We hypothesized that TfR1 on brain microvascular endothelial cells (BMEC) would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0423452cb56afafc71b8bcdf8ca0344
https://doi.org/10.1158/1535-7163.mct-17-1009
https://doi.org/10.1158/1535-7163.mct-17-1009
Autor:
Andrew Lozen, Christopher R. Chitambar, Mona M. Al-Gizawiy, Kimberly R. Pechman, Kathleen M. Schmainda, Janine P. Wereley
BACKGROUND: Limited treatment options and an aggressive nature make glioblastoma multiforme (GBM) a highly deadly cancer associated with poor prognosis and short survival. Gallium (Ga), an iron-mimetic metal, disrupts tumor iron homeostasis, thus eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf71d52ae52d0e1703fe2cdcc61e40e
https://europepmc.org/articles/PMC4638425/
https://europepmc.org/articles/PMC4638425/
Publikováno v:
International Journal of Cancer. 119:2200-2204
The antineoplastic agent doxorubicin inhibits cell growth through mechanisms that include an interaction with iron, resulting in the generation of cytotoxic reactive oxygen species (ROS). Prior studies have shown that the wild-type hemochromatosis ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ed1609666f2f864222b173af5fb31b
https://doi.org/10.1002/ijc.22079
https://doi.org/10.1002/ijc.22079
Publikováno v:
Neuro-Oncology. 18:vi63-vi64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbed2826ea7a114f2557d880795aaddc
https://doi.org/10.1093/neuonc/now212.265
https://doi.org/10.1093/neuonc/now212.265
Autor:
Janine P. Wereley, Christopher R. Chitambar, William E. Antholine, William J. O'Brien, Thomas Heiman
Publikováno v:
Biochemical Journal. 345:681-685
Ribonucleotide reductase is an iron-containing enzyme that is essential for DNA synthesis. Whereas previous studies have used various iron chelators to examine the relationship between cellular iron metabolism and ribonucleotide reductase activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ffbd6b790f6c426f3c884c16c2c0a8b
https://doi.org/10.1042/bj3450681
https://doi.org/10.1042/bj3450681
Publikováno v:
Blood. 91:4686-4693
Recent studies showed that gallium and iron uptake are decreased in gallium-resistant (R) CCRF-CEM cells; however, the mechanisms involved were not fully elucidated. In the present study, we compared the cellular uptake of 59Fe-transferrin (Tf) and59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f84b5c3e60448da5fb41d9dd94316e
https://doi.org/10.1182/blood.v91.12.4686
https://doi.org/10.1182/blood.v91.12.4686
Publikováno v:
Journal of Biological Chemistry. 272:12151-12157
The mechanism of drug resistance to gallium nitrate is not known. Since gallium can be incorporated into ferritin, an iron storage protein that protects cells from iron toxicity, we investigated whether ferritin expression was altered in gallium-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09a442d087d26430534bff15161dde9
https://doi.org/10.1074/jbc.272.18.12151
https://doi.org/10.1074/jbc.272.18.12151
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 322(3)
Clinical studies have shown gallium nitrate to have significant antitumor activity against non-Hodgkin's lymphoma and bladder cancer, thus indicating that gallium-based drugs have potential for further development as antineoplastic agents. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c65fa848bc473b4460d8a9f28d1f8a2
https://pubmed.ncbi.nlm.nih.gov/17600139
https://pubmed.ncbi.nlm.nih.gov/17600139
Publikováno v:
Molecular cancer therapeutics. 5(11)
Gallium nitrate is a metallodrug with clinical efficacy in non-Hodgkin's lymphoma. Its mechanisms of antineoplastic action are not fully understood. In the present study, we investigated the roles of transferrin receptor (TfR) targeting and apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80abac45f490a1b17c4260c2b1737e07
https://pubmed.ncbi.nlm.nih.gov/17121930
https://pubmed.ncbi.nlm.nih.gov/17121930
Publikováno v:
International journal of cancer. 119(9)
The antineoplastic agent doxorubicin inhibits cell growth through mechanisms that include an interaction with iron, resulting in the generation of cytotoxic reactive oxygen species (ROS). Prior studies have shown that the wild-type hemochromatosis ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1f39876eca848fb3eefe52003f48000
https://pubmed.ncbi.nlm.nih.gov/16823846
https://pubmed.ncbi.nlm.nih.gov/16823846