Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Janine Ondrus"'
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
Numerous mechanisms of resistance arise in response to treatment with second-generation androgen receptor (AR) pathway inhibitors in metastatic castration-resistant prostate cancer (mCRPC). Among these, point mutations in the ligand binding domain ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb756fdc24c04d7164e04381faf2716
https://doi.org/10.1158/1535-7163.c.6543534
https://doi.org/10.1158/1535-7163.c.6543534
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
Enzalutamide activates AR signaling in the absence of androgen in HepG2 transiently transfected with AR F877L and AR F877L/T878A constructs but not AR T878A only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f427283d55abb76e964cda4ea0a4f9
https://doi.org/10.1158/1535-7163.22522980
https://doi.org/10.1158/1535-7163.22522980
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
Kinase panel (KINOMEscan)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa35053fc761b250e3b1e58cb6ddca8
https://doi.org/10.1158/1535-7163.22522968.v1
https://doi.org/10.1158/1535-7163.22522968.v1
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
93-cell line proliferation assay was performed and data analyzed by OncoLead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c60f9d4ec5dd81e09281d56be0371c
https://doi.org/10.1158/1535-7163.22522971
https://doi.org/10.1158/1535-7163.22522971
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
JNJ-63576253 and enzalutamide inhibit KLK3 and FKBP5 mRNA expression in LNCaP AR/cs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a67e34f3b97f6a1cb6d6d88a89a877f
https://doi.org/10.1158/1535-7163.22522983
https://doi.org/10.1158/1535-7163.22522983
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
The synthetic androgen R1881 induces maximum proliferation in LNCaP AR/cs and LNCaP F877L cell lines at 0.1nM concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9357ac4b74d0a19b1138db2c193e9a97
https://doi.org/10.1158/1535-7163.22522977.v1
https://doi.org/10.1158/1535-7163.22522977.v1
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
Plasmid maps sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b412d4d52e0d535f1c8c6d13401b4a02
https://doi.org/10.1158/1535-7163.22522974.v1
https://doi.org/10.1158/1535-7163.22522974.v1
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
JNJ-63576253 inhibits AR nuclear localization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34804cb0125a81473c7d210b57a8ac51
https://doi.org/10.1158/1535-7163.22522962.v1
https://doi.org/10.1158/1535-7163.22522962.v1
Autor:
Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch
Body weights for LNCaP F877L xenograft model in castrated male SHO mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217aba4d9eeb9f12924f124c1bf8b96f
https://doi.org/10.1158/1535-7163.22522965.v1
https://doi.org/10.1158/1535-7163.22522965.v1
Autor:
Zhuming Zhang, Heng-Keang Lim, Jonathan Branch, Vineet Pande, Janine Ondrus, James R. Bischoff, Peter J. Connolly, Bush Tammy, Lieven Meerpoel, Ian Hickson, Christian Rocaboy, Luis B. Trabalón Escolar, Gilles Bignan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Androgen receptor (AR) transcriptional reactivation plays a key role in the development and progression of lethal castration-resistant prostate cancer (CRPC). Recurrent alterations in the AR enable persistent AR pathway signaling an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2583de003d65667131bf1b1caba4e
https://doi.org/10.1021/acsmedchemlett.1c00032
https://doi.org/10.1021/acsmedchemlett.1c00032
