Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Janine M. Lamonica"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that
Externí odkaz:
https://doaj.org/article/68674fac55494938b72e23f926e02371
Autor:
Bing Xu, Yugong Ho, Maria Fasolino, Joanna Medina, William Timothy O'Brien, Janine M Lamonica, Erin Nugent, Edward S Brodkin, Marc V Fuccillo, Maja Bucan, Zhaolan Zhou
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010659 (2023)
Copy number variations (CNVs) in the Neurexin 1 (NRXN1) gene, which encodes a presynaptic protein involved in neurotransmitter release, are some of the most frequently observed single-gene variants associated with autism spectrum disorder (ASD). To a
Externí odkaz:
https://doaj.org/article/e17dcd2428b74740955f0b5cd9f92273
Autor:
Darren Goffin, Golnaz Vahedi, George Georgakilas, Janine M. Lamonica, Zhaolan Zhou, Yue Cui, Ying-Tao Zhao, Kathleen H. Wood, Tae Hoon Kim, Brian S. Johnson, Maria Fasolino, Daniel Bu, Yoon Jung Kim
Publikováno v:
Nature Medicine. 23:1203-1214
Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder characterized by regressive loss of neurodevelopmental milestones and acquired psychomotor deficits. However, the cellular heterogeneity of the brain impedes an understan
Autor:
Janine M. Lamonica, Zhaolan Zhou
Publikováno v:
Curr Opin Genet Dev
Chromatin organization, together with DNA and histone modifications, is directly linked to the spatiotemporal control of gene expression that specifies and maintains cell type-specific functions. This is particularly important in the brain where hund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df5727a01a634509e075d89322c5f6b
https://europepmc.org/articles/PMC6759382/
https://europepmc.org/articles/PMC6759382/
Autor:
Tae Hoon Kim, Golnaz Vahedi, Brian S. Johnson, Ying-Tao Zhao, Chuan He, Maria Fasolino, Deborah Y. Kwon, Janine M. Lamonica, Zhaolan Zhou, Yoon Jung Kim, Boxuan Simen Zhao
Publikováno v:
Genome research. 28(7)
Genetic variants associated with autism spectrum disorders (ASDs) are enriched in genes encoding synaptic proteins and chromatin regulators. Although the role of synaptic proteins in ASDs is widely studied, the mechanism by which chromatin regulators
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene expression and cellular and behavioural phenotypes have been impeded by a lack of experimental tools. The Cas9 nuclease has been adapted to target epigenomic
Autor:
Brian S. Johnson, Hengyi Guo, Janine M. Lamonica, Yue Cui, Zhaolan Zhou, Sigrid C. Veasey, Darren Goffin, Deborah Y. Kwon, Polina Fenik
Publikováno v:
The Journal of clinical investigation. 127(5)
Mutations in the X-linked gene encoding methyl-CpG–binding protein 2 (MeCP2) cause Rett syndrome (RTT), a neurological disorder affecting cognitive development, respiration, and motor function. Genetic restoration of MeCP2 expression reverses RTT-l
Autor:
Stephanie A. Barnes, Silvia Bassani, Àlex Bayés, Elizabeth Berry-Kravis, Luigi Boccuto, Thomas Bourgeron, Jamel Chelly, Bice Chini, Jérôme Ezan, Jozef Gecz, Valentina Gigliucci, Xiaohong Gong, Seth G.N. Grant, Anne Hoffmann, Claire Homan, Elaine Y. Hsiao, Guillaume Huguet, Lachlan Jolly, Eunjoon Kim, Peter C. Kind, Jaewon Ko, Janine M. Lamonica, Marianna Leonzino, Natalia V. Malkova, Carla Marini, Caterina Michetti, Caterina Montani, Mireille Montcouquiol, Maïté M. Moreau, Edoardo Moretto, Alysson Renato Muotri, Emily K. Osterweil, Maria Passafaro, Olga Peñagarikano, Alan K. Percy, Duyen Pham, Katy Phelan, Laura Ricceri, Yoann Saillour, Carlo Sala, Nathalie Sans, Sara Sarasua, Maria Luisa Scattoni, Michael J. Schmeisser, Charles E. Schwartz, Yiping Shen, Chuan Tan, Daniel C. Tarquinio, Sophie R. Thomson, Chiara Verpelli, Kazuhiro Yamakawa, Zhaolan Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c97f80d4c0b770dbc0b6984c2acf55d
https://doi.org/10.1016/b978-0-12-800109-7.01002-5
https://doi.org/10.1016/b978-0-12-800109-7.01002-5
Autor:
Zhaolan Zhou, Janine M. Lamonica
Methyl-CpG binding protein 2 (MeCP2) is a member of the methyl-CpG binding domain family of nuclear proteins with binding affinity for methylated deoxyribonucleic acid. Mutations in the X-linked MECP2 gene are the monogenic origin of Rett syndrome (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71eafb140c41ac25ef46a739c29602a8
https://doi.org/10.1016/b978-0-12-800109-7.00007-8
https://doi.org/10.1016/b978-0-12-800109-7.00007-8
Autor:
Gerd A. Blobel, Roland Gamsjaeger, Janine M. Lamonica, Joel P. Mackay, Sarah R. Webb, Andrew N. Billin
Publikováno v:
Molecular and Cellular Biology. 31:2632-2640
Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize ac