Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Janine M. Bekker"'
Autor:
Rachelle H. Crosbie, Janine M. Bekker, Kari M. Morrissey, Kent L. Hill, Jessica R. Colantonio, Sarah J. Kim
Publikováno v:
Traffic. 7:538-548
The mammalian GAS11 gene is a candidate tumor suppressor of unknown function that was previously identified as one of several genes upregulated upon growth arrest. Interestingly, although GAS11 homologs in Trypanosoma brucei (trypanin) and Chlamydomo
Autor:
Stephen M. Black, Janine M. Bekker, Michael J. Johengen, Jeffrey R. Fineman, Stephan Thelitz, Regan B. Stuart, Boaz Ovadia
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 127:1285-1292
BackgroundInhaled nitric oxide produces potent pulmonary vasodilation by activating soluble guanylate cyclase and increasing smooth muscle cell concentrations of cyclic guanosine monophosphate. However, responses are often nonsustained, and clinicall
Autor:
Lucienne S Sanchez, Michael J. Johengen, Janine M. Bekker, Peter Oishi, Jeffrey R. Fineman, Stephan Thelitz, Stephen M. Black, Boaz Ovadia
Publikováno v:
Pediatric Critical Care Medicine. 5:234-239
OBJECTIVES: To determine the effects of inhaled nitric oxide on endogenous cyclic adenosine monophosphate in the intact lamb, and to determine the potential role of cyclic adenosine monophosphate in the rebound pulmonary hypertension associated with
Publikováno v:
DNA and Cell Biology. 22:317-328
Recent data has indicated that exogenous nitric oxide (NO) has the ability to decrease endogenous NO production by inhibiting the enzyme responsible for its generation, NO synthase (NOS). Our previous studies have indicated that increased generation
Publikováno v:
Journal of Biological Chemistry. 278:934-939
Double-stranded RNA (dsRNA) interference is a potent mechanism for sequence-specific silencing of gene expression and represents an invaluable approach for investigating gene function in normal and diseased states as well as for drug target validatio
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L490-L498
We have shown that increased pulmonary blood flow at birth increases the activity and expression of endothelial nitric oxide (NO) synthase (eNOS). However, the signal transduction pathway regulating this process is unclear. Because protein kinase C (
Autor:
D. Michael McMullan, Jeffrey R. Fineman, Stephen M. Black, R. Scott Heidersbach, Michael J. Johengen, Janine M. Bekker
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H1849-H1856
Life-threatening increases in pulmonary vascular resistance have been noted on acute withdrawal of inhaled nitric oxide (NO), although the mechanisms remain unknown. In vitro data suggest that exogenous NO exposure inhibits endothelial NO synthase (N
Publikováno v:
Pediatric Pulmonology. 28:3-11
Inhaled nitric oxide (NO) is currently used as an adjuvant therapy for a variety of pulmonary hypertensive disorders. In both animal and human studies, inhaled NO induces selective, dose-dependent pulmonary vasodilation. However, its potential intera
Publikováno v:
Molecular Brain Research. 64:165-178
PC12 cells are used as a model system to study neuronal differentiation. Nerve growth factor (NGF) triggers a differentiation pathway in PC12 cells. Neurite outgrowth (a morphological marker of differentiation) in PC12 cells is significantly reduced
Autor:
Christophe Guignabert, Niru Deshpande, Marlene Rabinovitch, Janine M. Bekker, Lingli Wang, Bin Zhou, Gordon M. Cann, Lihua Ying
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 237(1)
Murine light chain 3 (LC3) exists as two isoforms, LC3 and : LC3 is an RNA-binding protein that enhances fibronectin (FN) mRNA translation, and is also a marker of autophagy. We report embryonic expression patterns for LC3 and LC3, with some overlap