Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Janine M LaSalle"'
Autor:
Osman Sharifi, Viktoria Haghani, Kari E. Neier, Keith J. Fraga, Ian Korf, Sophia M. Hakam, Gerald Quon, Nelson Johansen, Dag H. Yasui, Janine M. LaSalle
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Dominant X-linked diseases are uncommon due to female X chromosome inactivation (XCI). While random XCI usually protects females against X-linked mutations, Rett syndrome (RTT) is a female neurodevelopmental disorder caused by heterozygous M
Externí odkaz:
https://doaj.org/article/27f2deea1c084c859913e45acdf66dda
Autor:
Diane I Schroeder, Kartika Jayashankar, Kory C Douglas, Twanda L Thirkill, Daniel York, Pete J Dickinson, Lawrence E Williams, Paul B Samollow, Pablo J Ross, Danika L Bannasch, Gordon C Douglas, Janine M LaSalle
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005442 (2015)
Over the last 20-80 million years the mammalian placenta has taken on a variety of morphologies through both divergent and convergent evolution. Recently we have shown that the human placenta genome has a unique epigenetic pattern of large partially
Externí odkaz:
https://doaj.org/article/79996a2623a44b2287a790eb77b0022b
Autor:
Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer, Philip J. Lupo, Jeremy M. Schraw, John P. Woodhouse, Adam J. de Smith, Janine M. LaSalle
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-18 (2023)
Abstract Background Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance are unknown. Previous studies have largely focused on identifying genetic risk f
Externí odkaz:
https://doaj.org/article/7d8ab561956d4e7a86e1153a556c2027
Autor:
George Eusebio Kuodza, Ray Kawai, Yunin J.L. Rodriguez, Julia S. Mouat, Sophia M. Hakam, Timothy N. Sullivan, Cole R. Torvick, Deborah Bennett, Irva Hertz-Picciotto, Janine M. LaSalle
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 169-169 (2024)
OBJECTIVES/GOALS: to investigate the potential impact of grandparental factors and multigenerational epigenetic inheritance on the development of ASD METHODS/STUDY POPULATION: Our study recruited participants from the CHARGE (Child Autism Risks from
Externí odkaz:
https://doaj.org/article/5602fbb4f9dd4c11bec540ab8b0e27eb
Autor:
Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugán, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Sáez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernández, Antonio Gómez-Martín, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasaña, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Räikkönen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic
Externí odkaz:
https://doaj.org/article/25f6e68216ef415aa23b5efa7f8762a9
Autor:
Benjamin I. Laufer, Yu Hasegawa, Zhichao Zhang, Casey E. Hogrefe, Laura A. Del Rosso, Lori Haapanen, Hyeyeon Hwang, Melissa D. Bauman, Judy Van de Water, Ameer Y. Taha, Carolyn M. Slupsky, Mari S. Golub, John P. Capitanio, Catherine A. VandeVoort, Cheryl K. Walker, Janine M. LaSalle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In animal models, maternal obesity is associated with development of neurodevelopmental disorder like phenotypes. Here the authors show in a macaque model that in obese dams, cell-free fetal DNA methylation, inflammatory cytokines, and metabolites co
Externí odkaz:
https://doaj.org/article/bfda17b385eb45c399ddcbf0d2cffdd0
Autor:
John F. Dou, Lauren Y. M. Middleton, Yihui Zhu, Kelly S. Benke, Jason I. Feinberg, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, Janine M. LaSalle, Daniele Fallin, Rebecca J. Schmidt, Kelly M. Bakulski
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, a
Externí odkaz:
https://doaj.org/article/709aaeea75ef4408ac5796d3affe2cdf
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methylation. The molecular
Externí odkaz:
https://doaj.org/article/e4bb9bad6e9843408caa47e3062cf23a
Autor:
Gaurav V. Sarode, Kari Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew L. Settles, Janine M. LaSalle, Valentina Medici
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1457-1477 (2021)
Background & Aims: The pathogenesis of Wilson disease (WD) involves hepatic and brain copper accumulation resulting from pathogenic variants affecting the ATP7B gene and downstream epigenetic and metabolic mechanisms. Prior methylome investigations i
Externí odkaz:
https://doaj.org/article/c5ffc517af1647e8b7ee2257791baec3
Autor:
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-25 (2020)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. The neonatal epigenome has the potential to reflect past interactions between genetic and environmental fact
Externí odkaz:
https://doaj.org/article/5daab9d3cbe4415ca5f185f325d2a213