Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen

Autor: Sara Wells, Marc Parisien, Abigail J. D’Souza, Rasneer Sonia Bains, Hamed Haselimashhadi, Mary E. Dickinson, Matthew Mckay, Amelia M. Willett, Christopher S. Ward, Robert Braun, Jeremy Mason, Stephen A. Murray, Emma Peterson, Michayla A. Moore, Damian Smedley, Erin E. Young, Luis Santos, Elissa L. Chesler, Laura C. Anderson, Rachel Urban, Helen Parkinson, Lynette Bower, John R. Seavitt, Dawei Qu, Leslie O. Goodwin, Vivek Kumar, Jason D. Heaney, Subhiksha Srinivasan, Kevin C K Lloyd, Mark E. Harrison, Steve D.M. Brown, Colin McKerlie, Ann M. Flenniken, Jacqueline K. White, Lauryl M. J. Nutter, Ziyue Huang, Jason A. Bubier, Daniel J. Delbarre, Robert P. Bonin, Kyle M. Baumbauer, Alexandr Bezginov, Dave Clary, Igor Vukobradovic, Ann-Marie Mallon, Silvia Mandillo, Luda Diatchenko, Surabi Veeraragavan, Michelle Stewart, Rodney C. Samaco, Janine M Wotton

Publikováno v: Pain (Amst. Print) (2021). doi:10.1097/j.pain.0000000000002481
info:cnr-pdr/source/autori:Wotton, Janine M.a; Peterson, Emmaa; Flenniken, Ann M.b,c; Bains, Rasneer S.d; Veeraragavan, Surabie,f; Bower, Lynette R.g; Bubier, Jason A.a; Parisien, March; Bezginov, Alexandrb,i; Haselimashhadi, Hamedj; Mason, Jeremyj; Moore, Michayla A.a; Stewart, Michelle E.d; Clary, Dave A.g; Delbarre, Daniel J.k; Anderson, Laura C.a; D'Souza, Abigailb,c; Goodwin, Leslie O.a; Harrison, Mark E.d; Huang, Ziyueb,c; Mckay, Matthewa; Qu, Daweib,c; Santos, Luisk; Srinivasan, Subhikshae; Urban, Rachela; Vukobradovic, Igorb,c; Ward, Christopher S.l; Willett, Amelia M.a; Braun, Robert E.a; Brown, Steve D.M.k; Dickinson, Mary E.l; Heaney, Jason D.e; Kumar, Viveka; Lloyd, K.C. Kentg,m; Mallon, Ann-Mariek; McKerlie, Colinc,i; Murray, Stephen A.a; Nutter, Lauryl M.J.b,i; Parkinson, Helenj; Seavitt, John R.e; Wells, Sarad; Samaco, Rodney C.e,f; Chesler, Elissa J.a; Smedley, Damiann; Diatchenko, Ludah; Baumbauer, Kyle M.o; Young, Erin E.p; Bonin, Robert P.q; Mandillo, Silviar; White, Jacqueline K.a,* The International Mouse Phenotyping Consortium/titolo:Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen/doi:10.1097%2Fj.pain.0000000000002481/rivista:Pain (Amst. Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

Identifying the genetic determinants of pain is a scientific imperative given the magnitude of the global health burden that pain causes. Here, we report a genetic screen for nociception, performed under the auspices of the International Mouse Phenot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ba3068c6fd21cd20d394b0472d1cb8
https://doi.org/10.1097/j.pain.0000000000002481

T Cells from NOD

Autor: Jeremy J, Racine, Harold D, Chapman, Rosalinda, Doty, Brynn M, Cairns, Timothy J, Hines, Abigail L D, Tadenev, Laura C, Anderson, Torrian, Green, Meaghan E, Dyer, Janine M, Wotton, Zoë, Bichler, Jacqueline K, White, Rachel, Ettinger, Robert W, Burgess, David V, Serreze

Publikováno v: J Immunol

It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D(4)) pathogenesis. In fact, a large proportion of islet-infiltrating B-lymphocytes in the NOD mouse model of T1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26a7f3116c975029d5c50a6907962edc
https://pubmed.ncbi.nlm.nih.gov/32938729

Using the Tools of Behavioral Neuroscience to Determine the Identity of Different Mouse Strains in a Laboratory Course

Autor: Janine M, Wotton, Michael J, Ferragamo

Publikováno v: Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 16(1)

Understanding the neural mechanisms underlying behavior depends on our ability to define and to measure these behaviors in the model animal. We describe an upper-level course which provides students with hands-on experience in the methods of behavior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67e83dbfeb88aeda9e11d8e5bc2d9283
https://pubmed.ncbi.nlm.nih.gov/29371839

The emergence of temporal hyperacuity from widely tuned cell populations

Autor: Janine M Wotton, Michael J Ferragamo, Mark I Sanderson

Publikováno v: Network: Computation in Neural Systems. 15:159-177

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a723e74fb70e6ecc550d216b89102057
https://doi.org/10.1088/0954-898x_15_3_001

A backpropagation network model of the monaural localization information available in the bat echolocation system

Autor: Janine M. Wotton, Rick L. Jenison

Publikováno v: The Journal of the Acoustical Society of America. 101:2964-2972

The information echolocating bats receive is a combination of the properties of the sound they emit and the sound they receive at the eardrum. Convolving the emission and the external ear transfer functions produces the full spectral information cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c27baff72b7f53818946c490c99c9
https://doi.org/10.1121/1.418524