Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Janine M, LaSalle"'
Autor:
Osman Sharifi, Viktoria Haghani, Kari E. Neier, Keith J. Fraga, Ian Korf, Sophia M. Hakam, Gerald Quon, Nelson Johansen, Dag H. Yasui, Janine M. LaSalle
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Dominant X-linked diseases are uncommon due to female X chromosome inactivation (XCI). While random XCI usually protects females against X-linked mutations, Rett syndrome (RTT) is a female neurodevelopmental disorder caused by heterozygous M
Externí odkaz:
https://doaj.org/article/27f2deea1c084c859913e45acdf66dda
Autor:
Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer, Philip J. Lupo, Jeremy M. Schraw, John P. Woodhouse, Adam J. de Smith, Janine M. LaSalle
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-18 (2023)
Abstract Background Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance are unknown. Previous studies have largely focused on identifying genetic risk f
Externí odkaz:
https://doaj.org/article/7d8ab561956d4e7a86e1153a556c2027
Autor:
George Eusebio Kuodza, Ray Kawai, Yunin J.L. Rodriguez, Julia S. Mouat, Sophia M. Hakam, Timothy N. Sullivan, Cole R. Torvick, Deborah Bennett, Irva Hertz-Picciotto, Janine M. LaSalle
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 169-169 (2024)
OBJECTIVES/GOALS: to investigate the potential impact of grandparental factors and multigenerational epigenetic inheritance on the development of ASD METHODS/STUDY POPULATION: Our study recruited participants from the CHARGE (Child Autism Risks from
Externí odkaz:
https://doaj.org/article/5602fbb4f9dd4c11bec540ab8b0e27eb
Autor:
Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugán, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Sáez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernández, Antonio Gómez-Martín, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasaña, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Räikkönen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic
Externí odkaz:
https://doaj.org/article/25f6e68216ef415aa23b5efa7f8762a9
Autor:
Benjamin I. Laufer, Yu Hasegawa, Zhichao Zhang, Casey E. Hogrefe, Laura A. Del Rosso, Lori Haapanen, Hyeyeon Hwang, Melissa D. Bauman, Judy Van de Water, Ameer Y. Taha, Carolyn M. Slupsky, Mari S. Golub, John P. Capitanio, Catherine A. VandeVoort, Cheryl K. Walker, Janine M. LaSalle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In animal models, maternal obesity is associated with development of neurodevelopmental disorder like phenotypes. Here the authors show in a macaque model that in obese dams, cell-free fetal DNA methylation, inflammatory cytokines, and metabolites co
Externí odkaz:
https://doaj.org/article/bfda17b385eb45c399ddcbf0d2cffdd0
Autor:
John F. Dou, Lauren Y. M. Middleton, Yihui Zhu, Kelly S. Benke, Jason I. Feinberg, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, Janine M. LaSalle, Daniele Fallin, Rebecca J. Schmidt, Kelly M. Bakulski
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, a
Externí odkaz:
https://doaj.org/article/709aaeea75ef4408ac5796d3affe2cdf
Autor:
Yihui Zhu, J. Antonio Gomez, Benjamin I. Laufer, Charles E. Mordaunt, Julia S. Mouat, Daniela C. Soto, Megan Y. Dennis, Kelly S. Benke, Kelly M. Bakulski, John Dou, Ria Marathe, Julia M. Jianu, Logan A. Williams, Orangel J. Gutierrez Fugón, Cheryl K. Walker, Sally Ozonoff, Jason Daniels, Luke P. Grosvenor, Heather E. Volk, Jason I. Feinberg, M. Daniele Fallin, Irva Hertz-Picciotto, Rebecca J. Schmidt, Dag H. Yasui, Janine M. LaSalle
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating the discovery of common genetic risk. The epigenetic layer of DNA methylation shows dynamic developmental changes an
Externí odkaz:
https://doaj.org/article/f6d35ff30916481bbb358c37ec11e956
Autor:
Kari Neier, Tianna E. Grant, Rebecca L. Palmer, Demario Chappell, Sophia M. Hakam, Kendra M. Yasui, Matt Rolston, Matthew L. Settles, Samuel S. Hunter, Abdullah Madany, Paul Ashwood, Blythe Durbin-Johnson, Janine M. LaSalle, Dag H. Yasui
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Using a mouse model for Rett syndrome (RTT), Neier et al analyze gut microbiome and metabolome profiles during disease progression. They show that pathophysiology and progression of RTT is different in females than in males and suggest that changes i
Externí odkaz:
https://doaj.org/article/c1d9cbe8712d4cf99e5108bdab6417d3
Autor:
Carrie V. Breton, Remy Landon, Linda G. Kahn, Michelle Bosquet Enlow, Alicia K. Peterson, Theresa Bastain, Joseph Braun, Sarah S. Comstock, Cristiane S. Duarte, Alison Hipwell, Hong Ji, Janine M. LaSalle, Rachel L. Miller, Rashelle Musci, Jonathan Posner, Rebecca Schmidt, Shakira F. Suglia, Irene Tung, Daniel Weisenberger, Yeyi Zhu, Rebecca Fry
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Carrie Breton and colleagues review the literature supporting evidence for transgenerational health effects of environmental exposures by epigenetic mechanisms. This Review summarizes current knowledge based on animal and human cohort studies, and di
Externí odkaz:
https://doaj.org/article/00ce9e7a61984501837c9203e195150e
Autor:
Angela G. Maggio, Henry T. Shu, Benjamin I. Laufer, Chongfeng Bi, Yinglei Lai, Janine M. LaSalle, Valerie W. Hu
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Environmental exposures to endocrine disrupting compounds (EDCs) such as the organochlorines have been linked with various diseases including neurodevelopmental disorders. Autism spectrum disorder (ASD) is a highly complex neurodevelopmental disorder
Externí odkaz:
https://doaj.org/article/4049fdc39ba74dbcb2ae582372ba4402