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TMET-04. DETECTING DYNAMIC PYRUVATE TUMOR METABOLISM IN PATIENTS WITH GLIOMA USING HYPERPOLARIZED CARBON-13 METABOLIC IMAGING

Autor: Yan Li, Janine Lupo, Adam Autry, Sana Vaziri, Jeremy Gordon, Marisa Lafontaine, Chen Hsin-Yu, Yaewon Kim, Jasmine Hu, Wendy Ma, Javier Villanueva-Meyer, Peder Larson, Duan Xu, Nancy Ann Oberheim Bush, Jennifer Clarke, Daniel Vigneron, Susan M Chang

Publikováno v: Neuro-Oncology. 24:vii261-vii262

INTRODUCTION Hyperpolarized carbon-13 (HP-13C) MR enables rapid dynamic imaging of metabolic pathways in the human brain using non-toxic, non-radioactive metabolites as tracers. This study presents our unique experience on the benefit of using [1-13C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3df37f9892592f6947a097344cdb696
https://doi.org/10.1093/neuonc/noac209.1009

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NIMG-61. IMPROVED GENERALIZABILITY OF RADIOPATHOMIC PROBABILISTIC MAPPING OF TREATMENT-INDUCED EFFECTS WITH PHYSIOLOGIC MR IMAGING AND DEEP LEARNING IN PATIENTS WITH RECURRENT GLIOBLASTOMA

Autor: Jacob Ellison, Nate Tran, Annette Molinaro, Valentina Pedoia, Joanna J Phillips, Anny Shai, Devika Nair, Marisa Lafontaine, Angela Jakary, Tracy Luks, Javier Villanueva-Meyer, Susan M Chang, Mitchel S Berger, Shawn L Hervey-Jumper, Manish Aghi, Janine Lupo

Publikováno v: Neuro-Oncology. 24:vii177-vii178

Although physiologic (diffusion-weighted and perfusion-weighted) MRI has shown promise in identifying regions of recurrent tumor (rTumor) in patients with glioblastoma suspected of progression, distinguishing treatment-induced effects (TxE) from rTum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0704af2c406288397314f79b7abea6b
https://doi.org/10.1093/neuonc/noac209.679

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NIMG-46. TOWARDS PREDICTING TUMOR AGGRESSIVENESS WITH RADIOPATHOMIC ANALYSIS OF MULTI-PARAMETRIC ANATOMICAL, DIFFUSION-WEIGHTED, AND METABOLIC MRI IN PATIENTS WITH NEWLY-DIAGNOSED GLIOMAS

Autor: Oluwaseun Adegbite, Nate Tran, Annette Molinaro, Joanna J Phillips, Jacob Ellison, Yan Li, Tracy Luks, Anny Shai, Devika Nair, Valentina Pedoia, Javier Villanueva-Meyer, Mitchel S Berger, Shawn L Hervey-Jumper, Manish Aghi, Janine Lupo

Publikováno v: Neuro-Oncology. 24:vii173-vii174

INTRODUCTION Pathologically aggressive tumor biology can extend beyond the contrast-enhancing or non-enhancing anatomical lesions in patients with glioma. Identification of malignant regions can help guide diagnosis and subsequent treatment planning.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f906051c0db98b17c1126f4f7e69330
https://doi.org/10.1093/neuonc/noac209.664

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NIMG-65. IMPROVED SPATIAL MAPPING OF TUMOR AGGRESSIVENESS WITH 1H MAGNETIC RESONANCE SPECTROSCOPY AND DEEP LEARNING IN PATIENTS WITH NEWLY-DIAGNOSED GLIOMA

Autor: Nate Tran, Yan Li, Jacob Ellison, Oluwaseun Adegbite, Joanna J Phillips, Annette Molinaro, Valentina Pedoia, Anny Shai, Devika Nair, Angela Jakary, Marisa Lafontaine, Javier Villanueva-Meyer, Mitchel S Berger, Shawn L Hervey-Jumper, Manish Aghi, Susan M Chang, Janine Lupo

Publikováno v: Neuro-Oncology. 24:vii179-vii179

INTRODUCTION Noninvasive, radiopathomic mapping of tumor aggressiveness can benefit patients with glioma by guiding the selection of tissue samples for diagnosis, increasing extent of resection, and non-invasively characterizing residual tumor burden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9abee7b55c6407561620d4b5a74db5f6
https://doi.org/10.1093/neuonc/noac209.683

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NIMG-24. LONGITUDINAL MR SPECTROSCOPY TO DETECT PROGRESSION IN PATIENTS WITH LOWER-GRADE GLIOMA IN THE SURVEILLANCE PHASE

Autor: Lauro Avalos, Tracy Luks, Tyler Gleason, Pablo Damasceno, Yan Li, Janine Lupo, Joanna J Phillips, Nancy Ann Oberheim Bush, Jennie Taylor, Susan M Chang, Javier Villanueva-Meyer

Publikováno v: Neuro-Oncology. 24:vii167-vii167

BACKGROUND Monitoring lower-grade gliomas (LrGGs) for disease progression is made difficult by the limits of anatomical MRI to distinguish treatment-related tissue changes from tumor progression. MR spectroscopic imaging (MRSI) offers additional meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c8517b7577e9da018bc09348698cae6
https://doi.org/10.1093/neuonc/noac209.642

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Abstract 3621: 3D spatial sampling and integrated omics reveal sources and patterning of intratumoral heterogeneity in glioblastoma

Autor: Radhika Mathur, Qixuan Wang, Patrick Schupp, Ana Nikolic, Takafumi Yamaguchi, Stephanie Hilz, Chibo Hong, Ivan Smirnov, Marisa LaFontaine, Joanna Phillips, Susan Chang, Yan Li, Janine Lupo, Paul Boutros, Marco Gallo, Michael Oldham, Feng Yue, Joseph Costello

Publikováno v: Cancer Research. 82:3621-3621

Treatment failure in glioblastoma, the most common and lethal primary brain tumor in adults, is often attributed to intratumoral heterogeneity as it fosters tumor evolution and selection of resistant clones. Sources of intratumoral heterogeneity may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c26a5eb8108260441214363fcc034685
https://doi.org/10.1158/1538-7445.am2022-3621

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QOL-53. GENOME ASSOCIATIONS WITH NEUROCOGNITIVE OUTCOMES, CEREBRAL MICROBLEEDS (CMBS), AND BRAIN VOLUME AND WHITE MATTER (WM) CHANGES IN PEDIATRIC BRAIN TUMOR SURVIVORS

Autor: Cassie Kline, Schuyler Stoller, Lennox Byer, Caleb Edwards, Rachna Prasad, Joseph Torkildson, Karen Gauvain, David Samuel, Janine Lupo, Melanie Morrison, Elizabeth Tong, Solomiia Savchuk, Christian Rodrigo Ugaz Valencia, Andreas Rauschecker, Jeffrey Rudie, Thomas Hoffman, Dena Dubal, Heather Fullerton, Sabine Mueller

Publikováno v: Neuro-oncology, vol 22, iss Suppl 3
Neuro-Oncology

OBJECTIVE To identify genetic predictors of neurocognition, CMBs, brain volume, and WM changes in pediatric brain tumor survivors. METHODS Patients were selected from an existing cohort (RadART) if they had: 1) at least one neurocognitive evaluation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc47292e44a1433d7f822c8baf603f0
https://escholarship.org/uc/item/0mp5s2h4

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NIMG-42. RECURRENT TUMOR AND TREATMENT-INDUCED EFFECTS HAVE DIFFERENT MR SIGNATURES IN CONTRAST ENHANCING AND NON-ENHANCING LESIONS OF HIGH-GRADE GLIOMAS

Autor: Julia Cluceru, Sarah Nelson, Annette Molinaro, Paula Alcaide-Leon, Marram Olson, Mitchel Berger, Susan Chang, Joanna Phillips, Devika Nair, Qiuting Wen, Javier Villanueva-Meyer, Pranathi Chunduru, Soonmee Cha, Janine Lupo

Publikováno v: Neuro Oncol

INTRODUCTION It is estimated that 25 to 35% of patients experience treatment-induced effects that can mimic recurrent high-grade gliomas. This diagnostic challenge is complicated by the coexistence of treatment-related changes and recurrent tumor wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefb3dad3d5d87ce97895390e05cb939
https://europepmc.org/articles/PMC6846948/

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A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors

Autor: Maryam, Vareth, Janine, Lupo, Peder, Larson, Sarah, Nelson

Publikováno v: NMR in biomedicine. 31(11)

The goal of this study was to find the most robust algorithm for a phase-sensitive coil combination of 3D single-cycle and lactate-edited, multi-channel H-1 point-resolved spectroscopy (PRESS) localized echo planar spectroscopic imaging (EPSI) data f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23f8c139072eb81e9db88fd2efccf166
https://pubmed.ncbi.nlm.nih.gov/30475426

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