Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Janine Lorrain"'
Autor:
Mostapha Matrougui, Paul J. Schaeffer, Zsolt Bocskei, Janine Lorrain, Jean-Marc Herbert, Christopher N. Berry, Jean-Claude Jetha, Stephen E. O'Connor, Lassalle Gilbert, Jean-Michel Altenburger, Jean-Pascal Herault, Catherine Lunven, Daniel Galtier
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1713-1730
SSR182289A 1 is the result of a rational optimisation process leading to an orally active thrombin inhibitor. The struc- ture incorporates an original 2-(acetylamino)-(1,1 0 -biphenyl)-3-sulfonyl N-terminal motif, a central l-Arg surrogate carrying a
Autor:
P. Schaeffer, L. Millet, M. Sainte-Marie, Jean-Marc Herbert, Janine Lorrain, C. Visconte, S. E. O'Connor
Publikováno v:
Journal of Thrombosis and Haemostasis. 2:629-636
The purpose of this work was to investigate whether thrombolysis induced by recombinant tissue plasminogen activator (rt-PA) or streptokinase (SK) was enhanced in different rabbit models of thrombolysis by SSR182289A, a novel synthetic direct thrombi
Autor:
Alain Grosset, Janine Lorrain, Evelyne Favennec, Véronique Briand, Nicole Duval, Christopher Latham, Christian Hoornaert, Gerard Cremer, Stephen E. O'Connor, Philip Janiak
Publikováno v:
British Journal of Pharmacology. 131:1188-1194
The NHE1 isoform of the Na+/H+ exchanger plays an important role in the regulation of intracellular pH and in cardiac cell injury caused by ischaemia and reperfusion. SL 59.1227 is a novel imidazolypiperidine Na+/H+ antiport inhibitor which is struct
Publikováno v:
European Journal of Pharmacology. 229:105-108
Putative 5-HT 4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD 2 of 6.7. Its effects were antagonised in a selective and c
Autor:
Régis Masson, Janine Lorrain, Jean-Pascal Herault, Jean-Marc Herbert, Nigel Roome, Paul J. Schaeffer, Stephen E. O'Connor, Christiane Gauffeny, Irène Lechaire
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(1)
SanOrg123781A is a synthetic hexadecasaccharide that displays antithrombin-dependent inhibition of factor Xa and thrombin and potent antithrombotic effects. The antithrombotic activity of SanOrg123781A has been studied in a new mouse model of arteria
Autor:
Jean-Marc Herbert, Christopher N. Berry, Paul J. Schaeffer, L. Millet, Irène Lechaire, Catherine Lunven, Janine Lorrain, C. Visconte, M. Sainte-Marie, S. E. O'Connor, S. Lochot, P. Ferrari
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 304(2)
N -[3-[[[(1 S )-4-(5-Amino-2-pyridinyl)-1-[[4-difluoromethylene)-1-piperidinyl]carbonyl]butyl]amino]sulfonyl][1,1′-biphenyl]-2-yl]acetamide hydrochloride (SSR182289A) is a novel, potent, and selective thrombin inhibitor. We have examined the antith
Autor:
Monique Delahaye, Andre Bernat, Paul J. Schaeffer, Philippe Janiak, Sylvette Lochot, Irène Lechaire, Patrice Ferrari, Jean-Marc Herbert, Alain Grosset, Stephen E. O'Connor, Pierre Savi, Janine Lorrain, Nicole Duval, Christopher N. Berry, Alain Lalé
Publikováno v:
Europe PubMed Central
SummaryThe antiplatelet and antithrombotic activity of SL65.0472 (7-fluoro-2-oxo-4-[2-[4-(thieno [3,2-c]pyrin-4-yl) piperazin-1-yl]ethyl]-1,2-dihydroquinoline-acetamide), a mixed 5-HT1B/5-HT2A receptor antagonist was investigated on 5HT-induced human
Autor:
C. Visconte, M. Sainte-Marie, P. Schaeffer, Janine Lorrain, S. E. O'Connor, L. Millet, J. M. Herbert
Publikováno v:
Journal of Thrombosis and Haemostasis. 1:P1845-P1845
Autor:
Janine, Lorrain, Irne, Lechaire, Christiane, Gauffeny, Rgis, Masson, Nigel, Roome, Jean-Pascal, Herault, Eric, O'Connor Stephen, Paul, Schaeffer, Jean-Marc, Herbert
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; April 2004, Vol. 309 Issue: 1 p235-40, 6p
Autor:
Françoise Lefèvre-Borg, Icilio Cavero, Janine Lorrain, Peter E. Hicks, Jacqueline Lechaire, Chantal Thiry
Publikováno v:
Journal of Cardiovascular Pharmacology. 11:444-455
In pentobarbital-anesthetized rats prepared for hemodynamic measurements with Doppler flow probes, intravenous (i.v.) infusions of fenoldopam (2.5 - 160.0 micrograms/kg/min during 15 min) decreased mean carotid artery blood pressure, total peripheral