Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Janine Kirstein"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Alfonso Schiavi, Claudia Cirotti, Lora-Sophie Gerber, Giulia Di Lauro, Silvia Maglioni, Priscila Yumi Tanaka Shibao, Sabrina Montresor, Janine Kirstein, Patrick Petzsch, Karl Köhrer, Roel P. F. Schins, Tina Wahle, Daniela Barilà, Natascia Ventura
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-22 (2023)
Abstract Alzheimer’s disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, dietary and environmental factors
Externí odkaz:
https://doaj.org/article/b943984ede4d4379a2a87b1088dc502b
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/34916ee468624348926a480d8f1c96e2
Autor:
Maria Lucia Pigazzini, Mandy Lawrenz, Anca Margineanu, Gabriele S. Kaminski Schierle, Janine Kirstein
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Huntington’s disease is a dominantly inherited neurodegenerative disorder caused by the expansion of a CAG repeat, encoding for the amino acid glutamine (Q), present in the first exon of the protein huntingtin. Over the threshold of Q39 HTT exon 1
Externí odkaz:
https://doaj.org/article/f23ad7c67f1d443d98b3d5a369fb13d2
Autor:
Patricia Kreis, Christian Gallrein, Eugenia Rojas-Puente, Till G. A. Mack, Cristina Kroon, Viktor Dinkel, Claudia Willmes, Kai Murk, Susanne tom-Dieck, Erin M. Schuman, Janine Kirstein, Britta J. Eickholt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance
Externí odkaz:
https://doaj.org/article/8f4a9676b36d4e899073e6805e0d669d
Autor:
Marie C. Lechler, Emily D. Crawford, Nicole Groh, Katja Widmaier, Raimund Jung, Janine Kirstein, Jonathan C. Trinidad, Alma L. Burlingame, Della C. David
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 454-467 (2017)
Summary: Low-complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggre
Externí odkaz:
https://doaj.org/article/b5d785eb2438408095c363dff5f3c2d9
Autor:
Diogo R. Feleciano, Katrin Juenemann, Manuel Iburg, Inês C. Brás, Carina I. Holmberg, Janine Kirstein
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can lead to the formation of misfolded and aggregated proteins that are a hallmark of protein co
Externí odkaz:
https://doaj.org/article/edb45883292f4b26948fa4d0fd6d07a9
Autor:
Vaishnavi Venugopalan, Alaa Al-Hashimi, Maren Rehders, Janine Golchert, Vivien Reinecke, Georg Homuth, Uwe Völker, Mythili Manirajah, Adam Touzani, Jonas Weber, Matthew S. Bogyo, Francois Verrey, Eva K. Wirth, Ulrich Schweizer, Heike Heuer, Janine Kirstein, Klaudia Brix
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 462 (2021)
The thyroid gland is both a thyroid hormone (TH) generating as well as a TH responsive organ. It is hence crucial that cathepsin-mediated proteolytic cleavage of the precursor thyroglobulin is regulated and integrated with the subsequent export of TH
Externí odkaz:
https://doaj.org/article/fb0e66208a4843bfaa24eb52398f0fab
Autor:
Vaishnavi Venugopalan, Maren Rehders, Jonas Weber, Lisa Rodermund, Alaa Al-Hashimi, Tonia Bargmann, Janine Golchert, Vivien Reinecke, Georg Homuth, Uwe Völker, Francois Verrey, Janine Kirstein, Heike Heuer, Ulrich Schweizer, Doreen Braun, Eva K Wirth, Klaudia Brix
Publikováno v:
Journal of molecular endocrinology. 70(1)
Proteolytic cleavage of thyroglobulin (Tg) for thyroid hormone (TH) liberation is followed by TH release from thyroid follicles into the circulation, enabled by TH transporters. The existence of a functional link between Tg-processing cathepsin prote
Autor:
Isabell Louise Grothaus, Giovanni Bussi, Janine Kirstein, Susan Köppen, Lucio Colombi Ciacchi
Publikováno v:
Biophysical Journal. 122:481a