Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Janine Kemming"'
Autor:
Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.
Externí odkaz:
https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee
Autor:
Dominik Wieland, Janine Kemming, Anita Schuch, Florian Emmerich, Percy Knolle, Christoph Neumann-Haefelin, Werner Held, Dietmar Zehn, Maike Hofmann, Robert Thimme
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells
Externí odkaz:
https://doaj.org/article/9297f10505a14ae8978a8c449887da65
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5644 (2020)
A functional adaptive immune response is the major determinant for clearance of hepatitis C virus (HCV) infection. However, in the majority of patients, this response fails and persistent infection evolves. Here, we dissect the HCV-specific key playe
Externí odkaz:
https://doaj.org/article/a131f472a44f40418ba7816a35406e9a
Autor:
Oezlem Sogukpinar, Julian Staniek, Sebastian Giese, Robert Thimme, Martin Schwemmle, Sagar, Iga Janowska, Katarina Stete, Hanna Hilger, Tobias Boettler, Janine Kemming, Valerie Oberhardt, Ales Janda, Maike Hofmann, Marta Rizzi, Julia Lang-Meli, Cornelius F. Waller, Georg Kochs, Katharina Wild, Kevin Ciminski, Benedikt Csernalabics, Jonas Fuchs, Katharina Zoldan, Kristi Basho, Fernando Topfstedt, Christoph Neumann-Haefelin, Isabel Schulien, Mircea Stefan Marinescu, Siegbert Rieg, Hendrik Luxenburger, Bertram Bengsch, Florian Emmerich
Publikováno v:
Nature. 597:268-273
SARS-CoV-2 spike mRNA vaccines1–3 mediate protection from severe disease as early as ten days after prime vaccination3, when neutralizing antibodies are hardly detectable4–6. Vaccine-induced CD8+ T cells may therefore be the main mediators of pro
Autor:
Oezlem Sogukpinar, Ralf Bartenschlager, Emma Gostick, Sagar, Dominik Wieland, Christian Conrad, Dominic Grün, Janine Kemming, Katharina Jechow, Bertram Bengsch, David Price, Naveed Ishaque, Robert Thimme, Zuguang Gu, Sian Llewellyn-Lacey, Christoph Neumann-Haefelin, Roland Eils, Maike Hofmann, Florian Emmerich, Nina Hensel, Tobias Boettler
Publikováno v:
Nature Immunology
In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise memory-like and terminally exhausted subsets. However, little is known about the molecular profile and fate of these two subsets after the elimination of chron
Autor:
Saskia Killmer, Marcus Panning, Janine Kemming, Robert Thimme, Alexandra Nieters, Christoph Neumann-Haefelin, Maike Hofmann, Franziska Daul, Henrik E. Mei, Florian Emmerich, Axel Schulz, Benedikt Binder, David Price, Sagar, Tobias Boettler, Isabel Schulien, Hendrik Luxenburger, Bertram Bengsch, Lea M. Seidel, Martin Schwemmle, Daniela Huzly, Siegbert Rieg, Marilyn Salvat Lago, Cornelius F. Waller, Daniel Duerschmied, Dominik Bettinger, Oezlem Sogukpinar, Georg Kochs, Valerie Oberhardt, Katharina Wild, Sian Llewellyn-Lacey, Annegrit Decker
Publikováno v:
Nature Medicine
Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral proteins are detectable in up to 70% of convalescent individuals. However, very little information is currently available about the abundance, phenotype, functiona
Autor:
Janine Kemming, Swantje Gundlach, Marcus Panning, Daniela Huzly, Jiabin Huang, Marc Lütgehetmann, Sven Pischke, Julian Schulze zur Wiesch, Florian Emmerich, Sian Llewellyn-Lacey, David A. Price, Yakup Tanriver, Klaus Warnatz, Tobias Boettler, Robert Thimme, Maike Hofmann, Nicole Fischer, Christoph Neumann-Haefelin
Publikováno v:
Journal of hepatology. 77(4)
In immunosuppressed patients, persistent HEV infection is common and may lead to cirrhosis and liver failure. HEV clearance depends on an effective virus-specific CD8+ T-cell response; however, the knowledge gap around HEV-specific CD8+ T-cell epitop
Autor:
Julius Beer, Marcus Panning, Robert Thimme, Janine Kemming, Lisa Kern, Daniela Huzly, Valeria Falcone, Jakob Ankerhold, Siegbert Rieg, Daniel Hornuss, Yakup Tanriver, Svenja Ulferts, Martin Schwemmle, Robert Grosse, Georg Kochs, Jonas Fuchs, Hendrik Luxenburger, Dirk Wagner, Gert Zimmer, Daniel Schnepf, Maike Hofmann, Christoph Neumann-Haefelin, Sebastian Weigang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Weigang, Sebastian; Fuchs, Jonas; Zimmer, Gert; Schnepf, Daniel; Kern, Lisa; Beer, Julius; Luxenburger, Hendrik; Ankerhold, Jakob; Falcone, Valeria; Kemming, Janine; Hofmann, Maike; Thimme, Robert; Neumann-Haefelin, Christoph; Ulferts, Svenja; Grosse, Robert; Hornuss, Daniel; Tanriver, Yakup; Rieg, Siegbert; Wagner, Dirk; Huzly, Daniela; ... (2021). Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nature Communications, 12(1), p. 6405. Springer Nature 10.1038/s41467-021-26602-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Weigang, Sebastian; Fuchs, Jonas; Zimmer, Gert; Schnepf, Daniel; Kern, Lisa; Beer, Julius; Luxenburger, Hendrik; Ankerhold, Jakob; Falcone, Valeria; Kemming, Janine; Hofmann, Maike; Thimme, Robert; Neumann-Haefelin, Christoph; Ulferts, Svenja; Grosse, Robert; Hornuss, Daniel; Tanriver, Yakup; Rieg, Siegbert; Wagner, Dirk; Huzly, Daniela; ... (2021). Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nature Communications, 12(1), p. 6405. Springer Nature 10.1038/s41467-021-26602-3
The origin of SARS-CoV-2 variants of concern remains unclear. Here, we test whether intra-host virus evolution during persistent infections could be a contributing factor by characterizing the long-term SARS-CoV-2 infection dynamics in an immunosuppr
Autor:
Kevin Ciminski, Fernando Topfstedt, Cornelius F. Waller, C Neumann-Haefelin, Jonas Fuchs, Marta Rizzi, Julian Staniek, Sebastian Giese, Benedikt Csernalabics, Siegbert Rieg, Maike Hofmann, Robert Thimme, Katharina Wild, Sagar Sagar, Katarina Stete, Julia Lang-Meli, Georg Kochs, Isabel Schulien, Mircea Stefan Marinescu, Martin Schwemmle, Oezlem Sogukpinar, Ales Janda, Florian Emmerich, Hendrik Luxenburger, Bertram Bengsch, Valerie Oberhardt, Katharina Zoldan, Hanna Hilger, Kristi Basho, Janine Kemming, Tobias Boettler, Iga Janowska
SARS-CoV-2 spike mRNA vaccines mediate protection from severe disease as early as 10 days post prime vaccination, when specific antibodies are hardly detectable and still lack neutralizing activity. Vaccine-induced T cells, especially CD8+ T cells, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8ca6be580eaa416e2781ff4c7b2bd1
https://doi.org/10.21203/rs.3.rs-505193/v1
https://doi.org/10.21203/rs.3.rs-505193/v1
Autor:
Valerie, Oberhardt, Hendrik, Luxenburger, Janine, Kemming, Isabel, Schulien, Kevin, Ciminski, Sebastian, Giese, Benedikt, Csernalabics, Julia, Lang-Meli, Iga, Janowska, Julian, Staniek, Katharina, Wild, Kristi, Basho, Mircea Stefan, Marinescu, Jonas, Fuchs, Fernando, Topfstedt, Ales, Janda, Oezlem, Sogukpinar, Hanna, Hilger, Katarina, Stete, Florian, Emmerich, Bertram, Bengsch, Cornelius F, Waller, Siegbert, Rieg, Sagar, Tobias, Boettler, Katharina, Zoldan, Georg, Kochs, Martin, Schwemmle, Marta, Rizzi, Robert, Thimme, Christoph, Neumann-Haefelin, Maike, Hofmann
Publikováno v:
Nature
SARS-CoV-2 spike mRNA vaccines1–3 mediate protection from severe disease as early as ten days after prime vaccination3, when neutralizing antibodies are hardly detectable4–6. Vaccine-induced CD8+ T cells may therefore be the main mediators of pro