Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Janine H. Santos"'
Autor:
Heather L. Vellers, Hye-Youn Cho, Wesley Gladwell, Kevin Gerrish, Janine H. Santos, Gaston Ofman, Laura Miller-DeGraff, T. Beth Mahler, Steven R. Kleeberger
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 760 (2022)
Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O2) in an extrauterine environment following birth. Supplemental O2 can induce oxidative stress that can impair mitochondrial function, resulting in lung injury and incr
Externí odkaz:
https://doaj.org/article/37b95ba35a3d4e7dad2fc02c2e9396ef
Autor:
Heather L. Vellers, Michael P. Massett, Josh J. Avila, Seung Kyum Kim, Jacqui M. Marzec, Janine H. Santos, J. Timothy Lightfoot, Steven R. Kleeberger
Publikováno v:
Physiological Reports, Vol 8, Iss 21, Pp n/a-n/a (2020)
Abstract In this pilot work, we selected two inbred strains that respond well to endurance training (ET) (FVB/NJ, and SJL/J strains), and two strains that respond poorly (BALB/cByJ and NZW/LacJ), to determine the effect of a standardized ET treadmill
Externí odkaz:
https://doaj.org/article/f83f0e9d508649ef92438b021c99dd60
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
To life scientists, one important feature offered by RNAseq, a next-generation sequencing tool used to estimate changes in gene expression levels, lies in its unprecedented resolution. It can score countable differences in transcript numbers among th
Externí odkaz:
https://doaj.org/article/6424576df8764681abf1a4f53861354a
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-2 (2023)
Graphical Abstract Gal et al address the issues raised by Gerber et al and reiterate that patients in their study showed decreased Misato homolog 1 (MSTO1) mRNA and protein levels, but also confirm finding of Gerber et al that the mutation is in MSTO
Externí odkaz:
https://doaj.org/article/f936b837a1d54a6289c22e3d1b498066
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(4)
Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic potential and cause long-term cardiovascular complications in cancer survivors. This has given rise to the field of cardio-oncology, which recognizes the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b443fcd0036ff4cbfa74ed316e8fc
https://pubmed.ncbi.nlm.nih.gov/35930448
https://pubmed.ncbi.nlm.nih.gov/35930448
Autor:
Brittany P. Rickard, Marta Overchuk, Girgis Obaid, Mustafa Kemal Ruhi, Utkan Demirci, Suzanne E. Fenton, Janine H. Santos, David Kessel, Imran Rizvi
Publikováno v:
Photochemistry and Photobiology. 99:448-468
Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target of increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83df4be57d25428857b9a8a73a8997c8
https://doi.org/10.1111/php.13723
https://doi.org/10.1111/php.13723
Publikováno v:
Am J Physiol Cell Physiol
Mitochondria are primarily involved in energy production through the process of oxidative phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function impacts a plethora of different cellular activities, including metabolism, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7f3a057c0bdd739d710d4747af5bf3
https://doi.org/10.1152/ajpcell.00389.2021
https://doi.org/10.1152/ajpcell.00389.2021
Autor:
Brittany P. Rickard, Marta Overchuk, Vesna A. Chappell, Mustafa Kemal Ruhi, Prima Dewi Sinawang, Tina Thuy Nguyen Hoang, Demir Akin, Utkan Demirci, Walfre Franco, Suzanne E. Fenton, Janine H. Santos, Imran Rizvi
Publikováno v:
Cancers. 15:2564
Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional changes can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cee6783345f665a5705133b2041acae
https://doi.org/10.3390/cancers15092564
https://doi.org/10.3390/cancers15092564
Autor:
Sheng Song, Qingshan Wang, Esteban A. Oyarzabal, Belinda Wilson, Janine H. Santos, Jau-Shyong Hong
Publikováno v:
Brain Behav Immun
Parkinson’s disease (PD) develops over decades through spatiotemporal stages that ascend from the brainstem to the forebrain. The mechanism behind this caudo-rostral neurodegeneration remains largely undefined. In unraveling this phenomenon, we rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28afe51fa3b3c3dd1a070984a49745e
https://doi.org/10.1016/j.bbi.2020.01.003
https://doi.org/10.1016/j.bbi.2020.01.003
Autor:
Jesse D. Cushman, Gonzalo Riadi, Janine H. Santos, Sheryl S. Moy, Patricia Jensen, Oswaldo A. Lozoya, Tianyuan Wang, Fuhua Xu, Richard P. Woychik, Dagoberto Grenet, Artiom Gruzdev, Thomas B Hagler, Korey D. Stevanovic, Bairon Hernandez
Publikováno v:
Life Science Alliance
This study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
PGC1α is a transcriptional coactivator i
PGC1α is a transcriptional coactivator i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5d14ad72249ac0290d81facc8447e7
https://pubmed.ncbi.nlm.nih.gov/34649938
https://pubmed.ncbi.nlm.nih.gov/34649938