Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD

Autor: Zachary N. Blalock, Gwyneth W. Y Wu, Daniel Lindqvist, Caroline Trumpff, Janine D. Flory, Jue Lin, Victor I. Reus, Ryan Rampersaud, Rasha Hammamieh, Aarti Gautam, SBPBC, Francis J. Doyle, Charles R. Marmar, Marti Jett, Rachel Yehuda, Owen M. Wolkowitz, Synthia H. Mellon

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet

Externí odkaz: https://doaj.org/article/462b504a442545f2add418e35eab0665

Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates

Autor: Carole E. Siegel, Eugene M. Laska, Ziqiang Lin, Mu Xu, Duna Abu-Amara, Michelle K. Jeffers, Meng Qian, Nicholas Milton, Janine D. Flory, Rasha Hammamieh, Bernie J. Daigle, Aarti Gautam, Kelsey R. Dean, Victor I. Reus, Owen M. Wolkowitz, Synthia H. Mellon, Kerry J. Ressler, Rachel Yehuda, Kai Wang, Leroy Hood, Francis J. Doyle, Marti Jett, Charles R. Marmar

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract We sought to find clinical subtypes of posttraumatic stress disorder (PTSD) in veterans 6–10 years post-trauma exposure based on current symptom assessments and to examine whether blood biomarkers could differentiate them. Samples were mal

Externí odkaz: https://doaj.org/article/e49caa92c9774a64b4ce6cfdf977ed9d

The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder

Autor: Frank R. Wendt, Miguel Garcia-Argibay, Brenda Cabrera-Mendoza, Unnur A. Valdimarsdóttir, Joel Gelernter, Murray B. Stein, Michel G. Nivard, Adam X. Maihofer, Caroline M. Nievergelt, Henrik Larsson, Manuel Mattheisen, Renato Polimanti, Sandra M. Meier, Karmel W. Choi, Jonathan R.I. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, Andrew Ratanatharathorn, Katy Torres, Aliza P. Wingo, Clement C. Zai, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegovic, Anders D. Borglum, Dragan Babic, Marie Bækvad-Hansen, Dewleen G. Baker, Jean C. Beckham, Laura J. Bierut, Jonathan I. Bisson, Marco P. Boks, Elizabeth A. Bolger, Bekh Bradley, Meghan Brashear, Gerome Breen, Richard A. Bryant, Angela C. Bustamante, Jonas Bybjerg-Grauholm, Joseph R. Calabrese, Jose Miguel Caldas-de-Almeida, Chia-Yen Chen, Anders M. Dale, Shareefa Dalvie, Jürgen Deckert, Douglas L. Delahanty, Michelle F. Dennis, Seth G. Disner, Katharina Domschke, Laramie E. Duncan, Alma Dzubur Kulenovic, Christopher R. Erbes, Alexandra Evans, Lindsay A. Farrer, Norah C. Feeny, Janine D. Flory, David Forbes, Carol E. Franz, Sandro Galea, Melanie E. Garrett, Aarti Gautam, Bizu Gelaye, Elbert Geuze, Charles F. Gillespie, Aferdita Goci Uka, Scott D. Gordon, Guia Guffanti, Rasha Hammamieh, Michael A. Hauser, Andrew C. Heath, Sian M.J. Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Karen-Inge Karstoft, Milissa L. Kaufman, Ronald C. Kessler, Alaptagin Khan, Nathan A. Kimbrel, Anthony P. King, Nastassja Koen, Henry R. Kranzler, William S. Kremen, Bruce R. Lawford, Lauren A.M. Lebois, Catrin Lewis, Israel Liberzon, Sarah D. Linnstaedt, Mark W. Logue, Adriana Lori, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Jessica L. Maples-Keller, Charles Marmar, Nicholas G. Martin, Douglas Maurer, Matig R. Mavissakalian, Alexander McFarlane, Regina E. McGlinchey, Katie A. McLaughlin, Samuel A. McLean, Divya Mehta, Rebecca Mellor, Vasiliki Michopoulos, William Milberg, Mark W. Miller, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Elliot C. Nelson, Merete Nordentoft, Sonya B. Norman, Meaghan O’Donnell, Holly K. Orcutt, Matthew S. Panizzon, Edward S. Peters, Alan L. Peterson, Matthew Peverill, Robert H. Pietrzak, Melissa A. Polusny, John P. Rice, Victoria B. Risbrough, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Kenneth J. Ruggiero, Ariane Rung, Bart P.F. Rutten, Nancy L. Saccone, Sixto E. Sanchez, Dick Schijven, Soraya Seedat, Antonia V. Seligowski, Julia S. Seng, Christina M. Sheerin, Derrick Silove, Alicia K. Smith, Jordan W. Smoller, Scott R. Sponheim, Dan J. Stein, Jennifer S. Stevens, Martin H. Teicher, Wesley K. Thompson, Edward Trapido, Monica Uddin, Robert J. Ursano, Leigh Luella van den Heuvel, Miranda Van Hooff, Eric Vermetten, Christiaan Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Thomas Werge, Michelle A. Williams, Douglas E. Williamson, Sherry Winternitz, Christiane Wolf, Erika J. Wolf, Rachel Yehuda, Keith A. Young, Ross McD. Young, Hongyu Zhao, Lori A. Zoellner, Magali Haas, Heather Lasseter, Allison C. Provost, Rany M. Salem, Jonathan Sebat, Richard Shaffer, Tianying Wu, Stephan Ripke, Mark J. Daly, Kerry J. Ressler, Karestan C. Koenen

Publikováno v: Biological psychiatry, 93(4), 362-369. Elsevier USA
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Valdimarsdóttir, U A, Gelernter, J, Stein, M B, Nivard, M G, Maihofer, A X, Nievergelt, C M, Larsson, H, Mattheisen, M, Polimanti, R, Meier, S M, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium & Mortensen, P B 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Nivard, M G, Polimanti, R, Mattheisen, M, Meier, S M & Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Biological Psychiatry, 93(4), 362-369. Elsevier USA

Background: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb06b6af7206f9c93a5adf8c62d986d
https://doi.org/10.1016/j.biopsych.2022.08.012

Altered gene expression and PTSD symptom dimensions in World Trade Center responders

Autor: Shelby Marchese, Leo Cancelmo, Olivia Diab, Leah Cahn, Cindy Aaronson, Nikolaos P. Daskalakis, Jamie Schaffer, Sarah R. Horn, Jessica S. Johnson, Clyde Schechter, Frank Desarnaud, Linda M. Bierer, Iouri Makotkine, Janine D. Flory, Michael Crane, Jacqueline M. Moline, Iris G. Udasin, Denise J. Harrison, Panos Roussos, Dennis S. Charney, Karestan C. Koenen, Steven M. Southwick, Rachel Yehuda, Robert H. Pietrzak, Laura M. Huckins, Adriana Feder

Publikováno v: Molecular Psychiatry. 27:2225-2246

Despite experiencing a significant trauma, only a subset of World Trade Center (WTC) rescue and recovery workers developed posttraumatic stress disorder (PTSD). Identification of biomarkers is critical to the development of targeted interventions for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ca546f2834da5cf14d56611143bd5
https://doi.org/10.1038/s41380-022-01457-2

Efficacy and Safety of Mifepristone in the Treatment of Male US Veterans With Posttraumatic Stress Disorder

Autor: Julia A. Golier, Xue Li, Marcel Bizien, Robin A. Hurley, Brendan W. Bechard, Timothy Kimbrell, Janine D. Flory, Dewleen G. Baker, Rachel Yehuda, Domenic J. Reda

Publikováno v: JAMA Network Open. 6:e2310223

ImportanceTo date, no psychopharmacologic treatment has been found to be uniformly effective in veterans with posttraumatic stress disorder (PTSD); novel targets and approaches are needed to treat this disabling disorder.ObjectiveTo examine whether t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba03ce7f31958cd0dc67a0934c18f733
https://doi.org/10.1001/jamanetworkopen.2023.10223