Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Janine D'Souza"'
Publikováno v:
Blood. 119(22)
Cells remove unstable polypeptides through protein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how these pathways are used in β-thalassemia, a common hemoglobinopathy in
Autor:
Xiaomei Wang, Janine D'Souza, David A. Gell, Mitchell J. Weiss, John S. Olson, Xiang Yu, Todd L. Mollan, Yu Yao, Eugene Khandros
Publikováno v:
The Journal of biological chemistry. 287(14)
α-Hemoglobin stabilizing protein (AHSP) is believed to facilitate adult Hemoglobin A assembly and protect against toxic free α-globin subunits. Recombinant AHSP binds multiple forms of free α-globin to stabilize their structures and inhibit precip
Autor:
Joanna B. Opalinska, Yu Yao, Wei Tong, Zhe Zhang, Alexey Bersenev, John K. Choi, Janine D'Souza, Alec A. Schmaier, Mitchell J. Weiss
MicroRNAs are small noncoding RNAs that regulate cellular development by interfering with mRNA stability and translation. We examined global microRNA expression during the differentiation of murine hematopoietic progenitors into megakaryocytes. Of 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce3485500d9b9e345a66ce15c101056
https://europepmc.org/articles/PMC3012601/
https://europepmc.org/articles/PMC3012601/
Autor:
Camila O. dos Santos, Wei Tong, Louis C. Dore, Janine D'Souza, Julio D. Amigo, Guowei Zhao, Mitchell J. Weiss, Duonan Yu, John K. Choi, Sherree Friend, Jordan S. Orange, Eugene Khandros, Jing Jiang, Barry H. Paw, Yu Yao, Saghi Ghaffari, Zhe Zhang
Publikováno v:
Genesdevelopment. 24(15)
The bicistronic microRNA (miRNA) locus miR-144/451 is highly expressed during erythrocyte development, although its physiological roles are poorly understood. We show that miR-144/451 ablation in mice causes mild erythrocyte instability and increased
Autor:
Richard S. Legro, Elizabeth C. Sefton, Geetha M. Nampiaparampil, Margrit Urbanek, Christine M. Ackerman, Andrea Dunaif, Janine D'Souza
Objective: We performed this study to test the hypothesis that variation in the lamin a/c gene (LMNA) contributes to milder phenotypes of insulin resistance, hyperandrogenism, and/or metabolic syndrome associated with polycystic ovary syndrome (PCOS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbd7439e56a4f94a44e28f3c3eff121
https://europepmc.org/articles/PMC5419178/
https://europepmc.org/articles/PMC5419178/