DTYMK is essential for genome integrity and neuronal survival

Autor: Jo M. Vanoevelen, Jörgen Bierau, Janine C. Grashorn, Ellen Lambrichs, Erik-Jan Kamsteeg, Levinus A. Bok, Ron A. Wevers, Marjo S. van der Knaap, Marianna Bugiani, Junmei Hu Frisk, Rita Colnaghi, Mark O’Driscoll, Debby M. E. I. Hellebrekers, Richard Rodenburg, Carlos R. Ferreira, Han G. Brunner, Arthur van den Wijngaard, Ghada M. H. Abdel-Salam, Liya Wang, Constance T. R. M. Stumpel

Publikováno v: Acta Neuropathologica, 143(2), 245-262. Springer Verlag
Acta Neuropathologica, 143, 2, pp. 245-262
Acta Neuropathologica, 143, 245-262
Vanoevelen, J M, Bierau, J R, Grashorn, J C, Lambrichs, E, Kamsteeg, E-J, Bok, L A, Wevers, R A, van der Knaap, M S, Bugiani, M, Frisk, J H, Colnaghi, R, O’Driscoll, M, Hellebrekers, D M E I, Rodenburg, R, Ferreira, C R, Brunner, H G, van den Wijngaard, A, Abdel-Salam, G M H, Wang, L & Stumpel, C T R M 2022, ' DTYMK is essential for genome integrity and neuronal survival ', Acta Neuropathologica, vol. 143, no. 2, pp. 245-262 . https://doi.org/10.1007/s00401-021-02394-0
Acta Neuropathologica, 143(2), 245-262. Springer, Cham
Acta Neuropathologica

Nucleotide metabolism is a complex pathway regulating crucial cellular processes such as nucleic acid synthesis, DNA repair and proliferation. This study shows that impairment of the biosynthesis of one of the building blocks of DNA, dTTP, causes a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cbd065e18192d0f5b5094c316c2f74
https://research.vumc.nl/en/publications/967a533e-3190-4119-814a-ebf8e8739321