Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Janine Schuurman"'
Autor:
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf
Externí odkaz:
https://doaj.org/article/36795cab2cda485e96053669065dc63a
Autor:
Timon Damelang, Maximilian Brinkhaus, Thijs L. J. van Osch, Janine Schuurman, Aran F. Labrijn, Theo Rispens, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody biology and structural protein engineering enabled the
Externí odkaz:
https://doaj.org/article/ff08febe557649c9b8dcd33d6f55e979
Autor:
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to i
Externí odkaz:
https://doaj.org/article/458e15a064ab40b08049bc6f97a6578d
Autor:
Leire Aguinagalde Salazar, Maurits A den Boer, Suzanne M Castenmiller, Seline A Zwarthoff, Carla de Haas, Piet C Aerts, Frank J Beurskens, Janine Schuurman, Albert JR Heck, Kok van Kessel, Suzan HM Rooijakkers
Publikováno v:
eLife, Vol 12 (2023)
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and an important cause of childhood mortality. Despite the introduction of successful vaccines, the global spread of both non-vaccine serotypes and antibiotic-resistant str
Externí odkaz:
https://doaj.org/article/8d74be0a69284980be16130f15cd03bf
Autor:
Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George W. Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, Sanjay Ram
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Neisseria gonorrhoeae
Externí odkaz:
https://doaj.org/article/f8a963212313460cb9282d3601ffc0c2
Autor:
Steven W. de Taeye, Arthur E. H. Bentlage, Mirjam M. Mebius, Joyce I. Meesters, Suzanne Lissenberg-Thunnissen, David Falck, Thomas Sénard, Nima Salehi, Manfred Wuhrer, Janine Schuurman, Aran F. Labrijn, Theo Rispens, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-recep
Externí odkaz:
https://doaj.org/article/7dd572adb41b4228b412bd1779181bed
Autor:
Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A. Methods: T-
Externí odkaz:
https://doaj.org/article/8eed60dbcc62461eb9d7224a1bb469dc
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Autor:
Alicia M Chenoweth, Sandra Esparon, Bruce D Wines, Janine Schuurman, Aran F Labrijn, P Mark Hogarth
Publikováno v:
Immunology & Cell Biology.
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Supplemental Tables Supplemental Figures Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc0742629adc9c9f5ee0bce476596b4
https://doi.org/10.1158/1535-7163.22520991.v1
https://doi.org/10.1158/1535-7163.22520991.v1