Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Janina Wittig"'
Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation
Autor:
Janina Wittig, Maria-Kyriaki Drekolia, Anastasia Kyselova, Fredy Delgado Lagos, Magdalena L. Bochenek, Jiong Hu, Katrin Schäfer, Ingrid Fleming, Sofia-Iris Bibli
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102694- (2023)
Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TF
Externí odkaz:
https://doaj.org/article/c64a64aa8ebc45a1b6f1d0275628ebc7
Autor:
Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxán, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metaboli
Externí odkaz:
https://doaj.org/article/1006b6d795e44cc8b2756328c762cb7b
Autor:
Sofia-Iris Bibli, Jiong Hu, Matthias S. Leisegang, Janina Wittig, Sven Zukunft, Andrea Kapasakalidi, Beate Fisslthaler, Diamantis Tsilimigras, Georgios Zografos, Konstantinos Filis, Ralf P. Brandes, Andreas Papapetropoulos, Fragiska Sigala, Ingrid Fleming
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Cystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H2Sn) in endothelial cells and plays an important role in protecting against atherosclerosis. Here we investigated the molecular mechanisms underlying the regulatio
Externí odkaz:
https://doaj.org/article/b82f9f2169ae4462a428be0f43fcc28e
Autor:
Sofia-Iris Bibli, Bert Luck, Sven Zukunft, Janina Wittig, Wei Chen, Ming Xian, Andreas Papapetropoulos, Jiong Hu, Ingrid Fleming
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 295-304 (2018)
Hydrogen sulfide (H2S) is a gasotransmitter that regulates cellular homeostasis and impacts on multiple physiological and pathophysiological processes. However, it exerts many of its biological actions indirectly via the formation of H2S-derived sulf
Externí odkaz:
https://doaj.org/article/ee3ee0d9c77446299f73470a60091a07
Autor:
Jiong Hu, Matthias S. Leisegang, Mario Looso, Gabrijela Dumbovic, Janina Wittig, Maria-Kyriaki Drekolia, Stefan Guenther, David John, Mauro Siragusa, Sven Zukunft, James Oo, Ilka Wittig, Susanne Hille, Andreas Weigert, Stefan Knapp, Ralf P. Brandes, Oliver J. Müller, Andreas Papapetropoulos, Fragiska Sigala, Gergana Dobreva, Ingrid Fleming, Sofia-Iris Bibli
AimsAdvanced age is unequivocally linked to the development of cardiovascular disease, however, the mechanisms leading to loss of endothelial cell regenerative capacity during aging remain poorly understood. Here we aimed to investigate novel mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9095d4723b704050d57a3f771ff2e151
https://doi.org/10.1101/2022.09.05.506654
https://doi.org/10.1101/2022.09.05.506654
Autor:
Mario Looso, Stefan Offermanns, Lukas Tombor, Voahanginirina Randriamboavonjy, Philipp Goymann, Anastasia Kyselova, Stephen L. Nishimura, Stefanie Dimmeler, Alberto Fernando Oliveira Justo, Matthias S. Leisegang, Sven Zukunft, Andreas Weigert, Andreas Papapetropoulos, Beate Fisslthaler, Sofia-Iris Bibli, Juliana Heidler, Janina Wittig, Ingrid Fleming, Corina Ratiu, Jiong Hu, Fragiska Sigala, Diamantis I. Tsilimigras, Stefan Knapp, Fredy Delgado Lagos, Ralf P. Brandes, Ilka Wittig, Maria Kyriaki Drekolia
Publikováno v:
Circulation. 143:935-948
Background: In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide–related sulfane sulfur compounds (H 2 S n ), that exert their biological actions via cysteine S -sulfhydration of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45fbc368eaf9af958ab0a083e4851697
https://doi.org/10.1161/circulationaha.120.051877
https://doi.org/10.1161/circulationaha.120.051877
Autor:
Hans-Peter Hammes, Sven Zukunft, Jihong Lin, Sofia-Iris Bibli, Ingrid Fleming, Jiong Hu, Janina Wittig, Rüdiger Popp
Publikováno v:
Journal of Clinical Investigation. 129:5204-5218
Polyunsaturated fatty acids such as docosahexaenoic acid (DHA) positively affect the outcome of retinopathy of prematurity (ROP). Given that DHA metabolism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects retinal angiogenesis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea1aca8e66c67d33cb4e947952495b0
https://doi.org/10.1172/jci123835
https://doi.org/10.1172/jci123835
Autor:
Christoph Schürmann, Juliana Heidler, Sofia Iris Bibli, Fragiska Sigala, Voahanginirina Randriamboavonjy, Bert Luck, Sven Zukunft, Ralf P. Brandes, Csaba Szabó, Andreas Papapetropoulos, Diamantis I. Tsilimigras, Mauro Siragusa, Daniel Siuda, Janina Wittig, Konstantinos Filis, Josef Pfeilschifter, Dao Wen Wang, Jiong Hu, George C. Zografos, Chen Chen, Randa Abdel Malik, Baktybek Kojonazarov, Ingrid Fleming, Ilka Wittig
Publikováno v:
Circulation. 139:101-114
Background: Hydrogen sulfide (H 2 S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1b4586c7c1292be70fe2d49ebe679e
https://doi.org/10.1161/circulationaha.118.034757
https://doi.org/10.1161/circulationaha.118.034757
Autor:
Sofia-Iris, Bibli, Jiong, Hu, Mario, Looso, Andreas, Weigert, Corina, Ratiu, Janina, Wittig, Maria Kyriaki, Drekolia, Lukas, Tombor, Voahanginirina, Randriamboavonjy, Matthias S, Leisegang, Philipp, Goymann, Fredy, Delgado Lagos, Beate, Fisslthaler, Sven, Zukunft, Anastasia, Kyselova, Alberto Fernando Oliveira, Justo, Juliana, Heidler, Diamantis, Tsilimigras, Ralf P, Brandes, Stefanie, Dimmeler, Andreas, Papapetropoulos, Stefan, Knapp, Stefan, Offermanns, Ilka, Wittig, Stephen L, Nishimura, Fragiska, Sigala, Ingrid, Fleming
Publikováno v:
Circulation. 143(9)
In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide-related sulfane sulfur compounds (HLiquid chromatography with tandem mass spectrometry was used to identifyThree paired sample sets wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67a8fb830bee58d21e2b91e825d394dd
https://pubmed.ncbi.nlm.nih.gov/33307764
https://pubmed.ncbi.nlm.nih.gov/33307764
Autor:
Konstantinos Filis, Fragiska Sigala, Sven Zukunft, Beate Fisslthaler, Janina Wittig, Ralf P. Brandes, Andreas Papapetropoulos, Matthias S. Leisegang, Sofia Iris Bibli, Andrea Kapasakalidi, Jiong Hu, Ingrid Fleming, Diamantis I. Tsilimigras, Georgios Zografos
Publikováno v:
Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology
Redox Biology
Cystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H2Sn) in endothelial cells and plays an important role in protecting against atherosclerosis. Here we investigated the molecular mechanisms underlying the regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2721769dfb88e312bc0265a9420acc7e
http://www.sciencedirect.com/science/article/pii/S2213231719312261
http://www.sciencedirect.com/science/article/pii/S2213231719312261