Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer’s disease from bioptic olfactory mucosa

Autor: Sina Hirschel, Monika Chongtham, Eckhardt Mandelkow, Friedrich Ihler, Markus Zweckstetter, Dietmar Riedel, Bernhard G. Weiss, Sebastian G. Russo, Lutz Trojan, Janina Trothe, Petra Wilken, Boris Schmidt, Hannah Pellkofer, Anja Schneider, Claudia Bartels, Elke Stransky, Marcel Kunadt, Harindranath Kadavath, Martin Canis, Finn Lornsen

Publikováno v: European archives of psychiatry and clinical neuroscience 269(8), 973-984 (2019). doi:10.1007/s00406-018-0955-6
European Archives of Psychiatry and Clinical Neuroscience

Alzheimer's disease (AD) pathology precedes the onset of clinical symptoms by several decades. Thus, biomarkers are required to identify prodromal disease stages to allow for the early and effective treatment. The methoxy-X04-derivative BSC4090 is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c8bb40b2ba9dca355f6aacf7951e11
https://doi.org/10.1007/s00406-018-0955-6

Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels

Autor: C. Buerger, Janina Trothe, Paul Scholz, V. Lang, Torsten Ertongur-Fauth, Roland Kaufmann, Dirk Ritzmann, Ümit Pul

Publikováno v: Experimental dermatology. 27(12)

The barrier function of the human epidermis is constantly challenged by environmental osmotic fluctuations. Hypotonic stress triggers cell swelling, which is counteracted by a compensatory mechanism called regulatory volume decrease (RVD) involving v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34194bf99838367e489239b8714b6af4
https://pubmed.ncbi.nlm.nih.gov/30252954