Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Janina Sprenger"'
Autor:
Marina Galchenkova, Alexandra Tolstikova, Bjarne Klopprogge, Janina Sprenger, Dominik Oberthuer, Wolfgang Brehm, Thomas A. White, Anton Barty, Henry N. Chapman, Oleksandr Yefanov
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 190-201 (2024)
Serial crystallography (SX) has become an established technique for protein structure determination, especially when dealing with small or radiation-sensitive crystals and investigating fast or irreversible protein dynamics. The advent of newly devel
Externí odkaz:
https://doaj.org/article/7172b08f189341d2b6450e8be4c657b5
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Janina Sprenger, Anda Trifan, Neal Patel, Ashley Vanderbeck, Jenny Bredfelt, Emad Tajkhorshid, Roger Rowlett, Leila Lo Leggio, Karin S. Åkerfeldt, Sara Linse
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 121-132 (2021)
Calmodulin (CaM) is a ubiquitous Ca2+ sensing protein that binds to and modulates numerous target proteins and enzymes during cellular signaling processes. A large number of CaM-target complexes have been identified and structurally characterized, re
Externí odkaz:
https://doaj.org/article/ca9bbe845bb241dc86a94af47d5c09fb
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163442 (2016)
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoM
Externí odkaz:
https://doaj.org/article/524d2ed8336943078a2f28ffb30c92d2
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
Sprenger, J, Lawson, C L, Von Wachenfeldt, C, Lo Leggio, L & Carey, J 2021, ' Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan ', Acta Crystallographica Section F: Structural Biology Communications, vol. 77, no. 7, pp. 215-225 . https://doi.org/10.1107/S2053230X21006142
Acta crystallographica / F 77(7), 215-225 (2021). doi:10.1107/S2053230X21006142
'Acta Crystallographica F ', vol: 77, pages: 215-225 (2021)
Sprenger, J, Lawson, C L, Von Wachenfeldt, C, Lo Leggio, L & Carey, J 2021, ' Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan ', Acta Crystallographica Section F: Structural Biology Communications, vol. 77, no. 7, pp. 215-225 . https://doi.org/10.1107/S2053230X21006142
Acta crystallographica / F 77(7), 215-225 (2021). doi:10.1107/S2053230X21006142
'Acta Crystallographica F ', vol: 77, pages: 215-225 (2021)
Acta crystallographica / F 77(7), 215 - 225 (2021). doi:10.1107/S2053230X21006142
The crystal structures of domain-swapped tryptophan repressor (TrpR) variant Val58Ile before and after soaking with the physiological ligand L-tryptophan (L-Trp) i
The crystal structures of domain-swapped tryptophan repressor (TrpR) variant Val58Ile before and after soaking with the physiological ligand L-tryptophan (L-Trp) i
Autor:
Paul Lourdu Xavier, Ajda Kunavar, Julia Maracke, Frederic Poitevin, Patrick Adams, Thomas D. Grant, Mark S. Hunter, Dominik Oberthuer, Janina Sprenger, Jannik Lübke, Amit K. Samanta, Jochen Küpper, Andrew V. Martin, Saša Bajt, Henry N. Chapman
Publikováno v:
Biophysical Journal. 122:545a
Autor:
Arwen R. Pearson, N. Ullah, Christian Betzel, M. Groessler, M. Galchenkova, Huijong Han, Winfried Hinrichs, Sebastian Guenther, Philipp Middendorf, Sven Falke, Hévila Brognaro, Markus Perbandt, L. Brings, Janina Sprenger, J. Lieske, Angelica Luana C Barra, Rafael Rahal Guaragna Machado, Kristina Lorenzen, Faisal H. M. Koua, Carsten Wrenger, Thomas J. Lane, Vasundara Srinivasan, Edmarci Elisa de Souza, Bruno Alves Franca, Patrick Y. A. Reinke, Alke Meents, J. Hakanpaeae, Prince Rajaiah Prabhu, M. Domaracky, Edison Luiz Durigon, Oleksandr Yefanov, F. Trost, Dušan Turk, H. Andaleeb, Danielle Bruna Leal Oliveira, Markus Wolf, M. Wang, Helen M. Ginn, Robin Schubert, W. Ewert, M. Schwinzer, N. Werner, C. Schmidt, Sofiane Saouane, Henry N. Chapman, Erika Donizette Candido, Luca Gelisio
SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to aid coron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::964928cd6675bbfb565ecc660007aa33
https://doi.org/10.1101/2021.11.17.468943
https://doi.org/10.1101/2021.11.17.468943
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163442 (2016)
PLoS ONE
PLoS ONE
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoM
Autor:
Lo Persson, Lyn-Marie Birkholtz, Abraham I. Louw, Marni Williams, Esmare Human, Salam Al-Karadaghi, Janina Sprenger
Publikováno v:
Molecular and Biochemical Parasitology. 180:17-26
Plasmodium falciparum like other organisms is dependent on polyamines for proliferation. Polyamine biosynthesis in these parasites is regulated by a unique bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase (PfAdoMetDC/ODC). Only
Autor:
Britt-Marie Sjöberg, Renzo Johansson, Janina Sprenger, Daniel Lundin, Derek T. Logan, Eduard Torrents, Margareta Sahlin
Publikováno v:
FEBS Journal. 277:4265-4277
The small flavoprotein NrdI is an essential component of the class Ib ribonucleotide reductase system in many bacteria. NrdI interacts with the class Ib radical generating protein NrdF. It is suggested to be involved in the rescue of inactivated dife