Výsledky vyhledávání - "Janina Schaller"

Precision Cut Cancer Tissue Slices in Anti-Cancer Drug Testing

Autor: Janina Schaller, Annika Sprüssel, Susanne Bentz, Hartmut Juhl, Cordula Rosenbrock, Jana Krüger, Florian T. Unger, Kerstin David, Katja Pursche

Publikováno v: Journal of Molecular Pathophysiology. 4:108

Background: To meet the urgent need to predict individual drug responses of patients and thus support drug development, better preclinical models of solid tumors are inevitable. Here, a newly developed precision cut cancer tissue slice culture is pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ae7198d0c4fcd70f5539eaa53a9dff6
https://doi.org/10.5455/jmp.20151023055556

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Abstract 913: Differences in basal isoform phosphorylation of signaling proteins between normal and tumor tissue in different cancer types detected by the NanoPro™1000 technology

Autor: Florian T. Unger, Hartmut Juhl, Kerstin David, Janina Schaller, Alexandra Samsen, Cordula Dede, Rebecca Giese, Jana Krueger

Publikováno v: Cancer Research. 74:913-913

In the era of targeted anticancer therapy, the proteomic analysis of cellular signaling networks has strongly gained in importance in the field of cancer research and treatment. There is scientific evidence that individual phosphorylation profiles of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63cc5ca72403c79e23528ba70db340cd
https://doi.org/10.1158/1538-7445.am2014-913

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NanoPro 1000 analysis of Erk1/2, Mek1/2, and Akt isoform phosphorylation in clinical samples from 115 patients

Autor: Florian T. Unger, Kerstin David, Hartmut Juhl, Cordula Dede, Rebecca Giese, Alexandra Samsen, Jana Krueger, Janina Schaller

Publikováno v: Journal of Clinical Oncology. 32:e22227-e22227

e22227 Background: Proteomic analysis of cellular signaling networks has strongly gained in importance in the field of cancer research and treatment. For example, the inhibition of the EGFR pathway has been widely integrated into clinical practice fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a60e493913406d3f7c004aa42616f3ff
https://doi.org/10.1200/jco.2014.32.15_suppl.e22227

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Abstract A40: Detection of Erk1/2, Mek1/2, and Akt isoform phosphorylation in tumors of 115 patients with different cancer types using the NanoPro™1000 technology

Autor: Giese Rebecca, Florian T. Unger, Cordula Dede, Kerstin David, Hartmut Juhl, Janina Schaller, Alexandra Samsen, Jana Krüger

Publikováno v: Molecular Cancer Therapeutics. 12:A40-A40

Proteomic analysis of cellular signaling networks has strongly gained in importance in the field of cancer research and treatment. In particular, there is a focus on the activation status of growth factor receptor related signaling cascades represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5169a4d1643d01194fc256c7b7753f88
https://doi.org/10.1158/1535-7163.targ-13-a40

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Abstract 2408: Comparison of ERK, AKT and MEK isoform phosphorylations between primary and corresponding metastatic colorectal carcinoma lesions using the NanoPro1000 technology

Autor: Florian T. Unger, Alexandra Samsen, Hartmut Juhl, Kerstin David, Cordula Dede, Jana Krueger, Janina Schaller

Publikováno v: Cancer Research. 73:2408-2408

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53bd316e0463724f0e080219fb79fd11
https://doi.org/10.1158/1538-7445.am2013-2408

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Abstract 3605: Effects of antibody-mediated EGF-receptor inhibition on ERK 1/2 isoform phosphorylation in organoid cultures

Autor: Hartmut Juhl, Janina Schaller, Florian T. Unger, Kerstin David, Jana Krueger, Cordula Rosenbrock, Birgit Rabe

Publikováno v: Cancer Research. 72:3605-3605

Inhibition of the EGF-receptor activity has been widely integrated into clinical practice for different tumor entities, e.g. non small lung cancer and colorectal cancer. Besides the application of tyrosine kinase inhibitors, anti-EGF-receptor treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f528865903b92e5fca6c7137e68868
https://doi.org/10.1158/1538-7445.am2012-3605

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Abstract C228: Preclinical analysis of therapeutic antibody efficiancy using an organoid model-based drug testing platform

Autor: Birgit Rabe, Jasmin Oehlmann, Cordula Rosenbrock, Hartmut Juhl, Janina Schaller, Florian T. Unger, Kerstin David, Jana Krueger, Christine Hein

Publikováno v: Molecular Cancer Therapeutics. 10:C228-C228

A common problem in translational research is the fact that findings from cell line experiments cannot be transferred one to one to the clinical setting, because each tumor consists of a variety of different cancer cells interacting with stroma cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203186769ab360cebf84dfde968207e8
https://doi.org/10.1158/1535-7163.targ-11-c228

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