Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations

Autor: Lamiaa Bahnassawy, Nathalie Nicolaisen, Christopher Untucht, Benjamin Mielich-Süss, Lydia Reinhardt, Janina S. Ried, Martina P. Morawe, Daniela Geist, Anja Finck, Elke Käfer, Jürgen Korffmann, Matthew Townsend, Brinda Ravikumar, Viktor Lakics, Miroslav Cik, Peter Reinhardt

Publikováno v: SLAS Discovery, Vol 29, Iss 2, Pp 100137- (2024)

Aberrant protein aggregation is a pathological cellular hallmark of many neurodegenerative diseases, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), where the tau protein is aggregating, forming neurofibrillary tangles (NFTs), and

Externí odkaz: https://doaj.org/article/88acc957513a468cbf3eadb12ef4e1e8

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Autor: Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stéphanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J.E. Rinkel, Jan H. Veldink, Ynte M. Ruigrok, Anne Hege Aamodt, Anne Heidi Skogholt, Ben M Brumpton, Cristen J Willer, Else C Sandset, Espen S Kristoffersen, Hanne Ellekjær, Ingrid Heuch, Jonas B Nielsen, Knut Hagen, Kristian Hveem, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Oddgeir L Holmen, Sigrid Børte, Wei Zhou, Shérine Abboud, Massimo Pandolfo, Vincent Thijs, Didier Leys, Marie Bodenant, Fabien Louillet, Emmanuel Touzé, Jean-Louis Mas, Yves Samson, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Sandrine Canaple, Olivier Godefroy, Maurice Giroud, Yannick Béjot, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Jean Dallongeville, Antti J Metso, Tiina Metso, Turgut Tatlisumak, Caspar Grond-Ginsbach, Christoph Lichy, Manja Kloss, Inge Werner, Marie-Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Constanze Thomas-Feles, Ralf Weber, Tobias Brandt, Alessandro Pezzini, Valeria De Giuli, Filomena Caria, Loris Poli, Alessandro Padovani, Anna Bersano, Silvia Lanfranconi, Simone Beretta, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Philippe Lyrer, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Leo Bonati, Henrik Gensicke, Margareth Amort, Hugh Markus, Jennifer Majersik, Bradford Worrall, Andrew Southerland, John Cole, Steven Kittner, Evangelos Evangelou, Helen R Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian’an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin Lehne, Terho Lehtimäki, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, YongMei Liu, Ruth JF Loos, Lorna M Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O’Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Quang Tri Nguyen, Olli T Raitakari, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Daniel I Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Bruce M. Psaty, Louise V Wain, Paul Elliott, Mark J Caulfield, Padhraig Gormley, Verneri Anttila, Priit Palta, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Lynn Cherkas, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Maija Wessman, Arn M J M van den Maagdenberg, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Dale R Nyholt, Masato Akiyama, Varinder S. Alg, Joseph P. Broderick, Ben M. Brumpton, Jérôme Dauvillier, Hubert Desal, Christian Dina, Christoph M. Friedrich, Emília I. Gaál-Paavola, Jean-Christophe Gentric, Sven Hirsch, Isabel C. Hostettler, Henry Houlden, Juha E. Jääskeläinen, Marianne Bakke Johnsen, Liming Li, Kuang Lin, Antti Lindgren, Olivier Martin, Koichi Matsuda, Iona Y. Millwood, Olivier Naggara, Mika Niemelä, Joanna Pera, Richard Redon, Guy A. Rouleau, Marie Søfteland Sandvei, Sabine Schilling, Eimad Shotar, Agnieszka Slowik, Chikashi Terao, W. M. Monique Verschuren, Robin G. Walters, David J. Werring, Cristen J. Willer, Daniel Woo, Bradford B. Worrall, Sirui Zhou

Publikováno v: Bakker, M K, Kanning, J P, Abraham, G, Martinsen, A E, Winsvold, B S, Zwart, J-A, Bourcier, R, Sawada, T, Koido, M, Kamatani, Y, Morel, S, Amouyel, P, Debette, S, Bijlenga, P, Berrandou, T, Ganesh, S K, Bouatia-Naji, N, Jones, G, Bown, M, Rinkel, G J E, Veldink, J H, Ruigrok, Y M, Hege Aamodt, A, Heidi Skogholt, A, Brumpton, B M, Willer, C J, Sandset, E C, Kristoffersen, E S, Ellekjær, H, Heuch, I, Nielsen, J B, Hagen, K, Hveem, K, Fritsche, L G, Thomas, L F, Pedersen, L M, Gabrielsen, M E, Holmen, O L, Børte, S, Zhou, W, Abboud, S, Pandolfo, M, Thijs, V, Leys, D, Bodenant, M, Louillet, F, Touzé, E, Mas, J-L, Samson, Y, Leder, S, Léger, A, Deltour, S, Crozier, S, Méresse, I, Canaple, S, Godefroy, O, Giroud, M, Béjot, Y, Decavel, P, Medeiros, E, Montiel, P, Moulin, T, Vuillier, F, Dallongeville, J, Metso, A J, Metso, T, Tatlisumak, T, Grond-Ginsbach, C, Lichy, C, Kloss, M, Werner, I, Arnold, M-L, Dos Santos, M, Grau, A, Dichgans, M, Thomas-Feles, C, Weber, R, Brandt, T, Pezzini, A, de Giuli, V, Caria, F, Poli, L, Padovani, A, Bersano, A, Lanfranconi, S, Beretta, S, Ferrarese, C, Giacolone, G, Paolucci, S, Lyrer, P, Engelter, S, Fluri, F, Hatz, F, Gisler, D, Bonati, L, Gensicke, H, Amort, M, Markus, H, Majersik, J, Worrall, B, Southerland, A, Cole, J, Kittner, S, Evangelou, E, Warren, H R, Gao, H, Ntritsos, G, Dimou, N, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Ding, J, Giulianini, F, Holliday, E G, Jackson, A U, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Peter Prins, B, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S B, Verweij, N, Willems, S M, Zhao, J-H, Connell, J, de Mutsert, R, Doney, A S F, Farrall, M, Menni, C, Morris, A D, Noordam, R, Paré, G, Poulter, N R, Shields, D C, Stanton, A, Thom, S, Abecasis, G, Amin, N, Arking, D E, Ayers, K L, Barbieri, C M, Batini, C, Bis, J C, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, D I, Bottinger, E P, Braund, P S, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, J C, Chauhan, G, Ciullo, M, Cocca, M, Collins, F, Cordell, H J, Davies, G, de Borst, M H, de Geus, E J, Deary, I J, Deelen, J, del Greco M, F, Yusuf Demirkale, C, Dörr, M, Ehret, G B, Elosua, R, Enroth, S, Mesut Erzurumluoglu, A, Ferreira, T, Frånberg, M, Franco, O H, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, A J, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, T B, Harris, S E, Hartman, C A, Havulinna, A S, Hicks, A A, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, J E, Hwang, S-J, Ingelsson, E, James, A, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, A D, Joshi, P K, Jousilahti, P, Wouter Jukema, J, Jula, A, Kähönen, M, Kathiresan, S, Keavney, B D, Khaw, K-T, Knekt, P, Knight, J, Kolcic, I, Kooner, J S, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, L J, Lehne, B, Lehtimäki, T, Liewald, D C M, Lin, L, Lind, L, Lindgren, C M, Liu, Y, Loos, R J F, Lopez, L M, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, A P, Morrison, A C, Munson, P J, Nalls, M A, Nandakumar, P, Nelson, C P, Niiranen, T, Nolte, I M, Nutile, T, Oldehinkel, A J, Oostra, B A, O'reilly, P F, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Wjh Penninx, B, Perola, M, Peters, A, Polasek, O, Pramstaller, P P, Tri Nguyen, Q, Raitakari, O T, Rettig, R, Rice, K, Ridker, P M, Ried, J S, Riese, H, Ripatti, S, Robino, A, Rose, L M, Rotter, J I, Rudan, I, Ruggiero, D, Saba, Y, Sala, C F, Salomaa, V, Samani, N J, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N, Siscovick, D, Smith, A V, Snieder, H, Sõber, S, Sorice, R, Starr, J M, Stott, D J, Strachan, D P, Strawbridge, R J, Sundström, J, Swertz, M A, Taylor, K D, Teumer, A, Tobin, M D, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, A G, Vaez, A, van der Most, P J, van Duijn, C M, Verwoert, G C, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, S H, Willemsen, G, Wilson, J F, Wright, A F, Yao, J, Zemunik, T, Zhang, W, Attia, J R, Butterworth, A S, Chasman, D I, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, J M M, Laakso, M, Lakatta, E G, Langenberg, C, Melander, O, Mook-Kanamori, D O, Palmer, C N A, Risch, L, Scott, R A, Scott, R J, Sever, P, Spector, T D, van der Harst, P, Wareham, N J, Zeggini, E, Levy, D, Munroe, P B, Newton-Cheh, C, Brown, M J, Metspalu, A, Psaty, B M, Wain, L V, Elliott, P, Caulfield, M J, Gormley, P, Anttila, V, Palta, P, Esko, T, Pers, T H, Farh, K-H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, Mcmahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A-P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Gudlaug Hrafnsdottir, M, Stefansson, H, Ring, S M, Hottenga, J-J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Heath, A C, Madden, P A F, Martin, N G, Montgomery, G W, Kurki, M I, Kals, M, Mägi, R, Pärn, K, Hämäläinen, E, Huang, H, Byrnes, A E, Franke, L, Huang, J, Stergiakouli, E, Lee, P H, Sandor, C, Webber, C, Cader, Z, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, J G, Salomaa, V, Heikkilä, K, Loehrer, E, Uitterlinden, A G, Hofman, A, van Duijn, C M, Cherkas, L, Pedersen, L M, Stubhaug, A, Nielsen, C S, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, A-L, Francke Christensen, A, Folkmann Hansen, T, Werge, T, Kaprio, J, Aromaa, A J, Raitakari, O, Arfan Ikram, M, Spector, T, Järvelin, M-R, Metspalu, A, Kubisch, C, Strachan, D P, Ferrari, M D, Belin, A C, Dichgans, M, Wessman, M, van den Maagdenberg, A M J M, Boomsma, D I, Davey Smith, G, Stefansson, K, Eriksson, N, Daly, M J, Neale, B M, Olesen, J, Chasman, D I, Nyholt, D R, Palotie, A, Akiyama, M, Alg, V S, Børte, S, Broderick, J P, Brumpton, B M, Dauvillier, J R, Desal, H, Dina, C, Friedrich, C M, Gaál-Paavola, E I, Gentric, J-C, Hirsch, S, Hostettler, I C, Houlden, H, Hveem, K, Jääskeläinen, J E, Johnsen, M B, Li, L, Lin, K, Lindgren, A, Martin, O, Matsuda, K, Millwood, I Y, Naggara, O, Niemelä, M, Pera, J, Redon, R, Rouleau, G A, Sandvei, M S F, Schilling, S, Shotar, E, Slowik, A, Terao, C, Verschuren, W M M, Walters, R G, Werring, D J, Willer, C J, Woo, D, Worrall, B B & Zhou, S 2023, ' Genetic Risk Score for Intracranial Aneurysms : Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity ', Stroke, vol. 54, no. 3, pp. 810-818 . https://doi.org/10.1161/STROKEAHA.122.040715
Stroke, 54(3), 810-818. Lippincott Williams and Wilkins
Bakker, M K, Kanning, J P, Abraham, G, Rinkel, G J E, Veldink, J H, Ruigrok, Y M, Boomsma, D I, de Geus, E J C, Hottenga, J-J, Jansen, R, Milaneschi, Y, Willemsen, G, Ligthart, L & The International Headache Genetics Consortium (IHGC) 2023, ' Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity ', Stroke, vol. 54, no. 3, pp. 810-818 . https://doi.org/10.1161/STROKEAHA.122.040715
Stroke
Stroke, 2023, 54 (3), pp.810-818. ⟨10.1161/strokeaha.122.040715⟩
Bakker, M K, Kanning, J P, Abraham, G, Martinsen, A E, Winsvold, B S, Zwart, J-A, Bourcier, R, Sawada, T, Koido, M, Kamatani, Y, Morel, S, Amouyel, P, Debette, S, Bijlenga, P, Berrandou, T, Ganesh, S K, Bouatia-Naji, N, Jones, G, Bown, M, Rinkel, G J E & Veldink, J H & Ruigrok, Y M 2023, ' Genetic Risk Score for Intracranial Aneurysms : Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity ', Stroke, vol. 54, no. 3, pp. 810-818 . https://doi.org/10.1161/STROKEAHA.122.040715
Stroke, 2023, ⟨10.1161/strokeaha.122.040715⟩

Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36628fefb56d299663379ef5e8719f53
https://doi.org/10.1161/strokeaha.122.040715

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Autor: M. Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M. Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L. Koller, Zoltán Kutalik, Jian’an Luan, Ida Malkin, Janina S. Ried, Albert V. Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J. Baier, Inês Barroso, David A. Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B. Borecki, Aron S. Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A. Cauley, Peggy M. Cawthon, Henna Cederberg, Zhao Chen, Nam H. Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R. Cummings, Philip L. De Jager, Ilja Demuth, Rosalie A. M. Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W. Enneman, Mike Erdos, Johan G. Eriksson, Joel Eriksson, Karol Estrada, Daniel S. Evans, Mary F. Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L. Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L. Hanson, Caroline Hayward, Albert Hofman, Eric P. Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J. Hubal, Alan Hubbard, Kim M. Huffman, Lise B. Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M. Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O. Kilpeläinen, Norman Klopp, Jacqueline S. L. Kloth, Heikki A. Koistinen, William E. Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L. Langdahl, Lenore J. Launer, Jong-Young Lee, Markus M. Lerch, Joshua R. Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N. Luben, William Maixner, Fiona E. McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D. Mitchell, Andrew P. Morris, Leif Mosekilde, Anne Newman, Carrie M. Nielson, Jeffrey R. O’Connell, Ben A. Oostra, Eric S. Orwoll, Aarno Palotie, Stephen C. J. Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L. Prince, Katri Räikkönen, Stuart H. Ralston, Samuli Ripatti, John A. Robbins, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E. Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A. Streeten, Unnur Styrkarsdottir, Karin M. A. Swart, Sian-Tsung Tan, Mark A. Tarnopolsky, Patricia Thompson, Cynthia A. Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J. Tranah, Jaakko Tuomilehto, Natasja M. van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N. Weedon, Ryan Welch, H.-Erich Wichmann, Elisabeth Widen, Frances M. K. Williams, James F. Wilson, Nicole C. Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C. Chambers, Angela Döring, Cornelia M. van Duijn, Michael J. Econs, Vilmundur Gudnason, Jaspal S. Kooner, Bruce M. Psaty, Timothy D. Spector, Kari Stefansson, Fernando Rivadeneira, André G. Uitterlinden, Nicholas J. Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J. F. Loos, David Karasik, Tamara B. Harris, Claes Ohlsson, Douglas P. Kiel

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-4 (2017)

A correction to this article has been published and is linked from the HTML version of this article.

Externí odkaz: https://doaj.org/article/dba3bf37aec64af2a93c8d1bb6cfdcb4

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Autor: M. Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M. Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L. Koller, Zoltán Kutalik, Jian’an Luan, Ida Malkin, Janina S. Ried, Albert V. Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J. Baier, Inês Barroso, David A. Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B. Borecki, Aron S. Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A. Cauley, Peggy M. Cawthon, Henna Cederberg, Zhao Chen, Nam H. Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R. Cummings, Philip L. De Jager, Ilja Demuth, Rosalie A. M. Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W. Enneman, Mike Erdos, Johan G. Eriksson, Joel Eriksson, Karol Estrada, Daniel S. Evans, Mary F. Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L. Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L. Hanson, Caroline Hayward, Albert Hofman, Eric P. Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J. Hubal, Alan Hubbard, Kim M. Huffman, Lise B. Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M. Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O. Kilpeläinen, Norman Klopp, Jacqueline S. L. Kloth, Heikki A. Koistinen, William E. Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L. Langdahl, Lenore J. Launer, Jong-Young Lee, Markus M. Lerch, Joshua R. Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N. Luben, William Maixner, Fiona E. McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D. Mitchell, Andrew P. Morris, Leif Mosekilde, Anne Newman, Carrie M. Nielson, Jeffrey R. O’Connell, Ben A. Oostra, Eric S. Orwoll, Aarno Palotie, Stephen C. J. Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L. Prince, Katri Räikkönen, Stuart H. Ralston, Samuli Ripatti, John A. Robbins, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E. Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A. Streeten, Unnur Styrkarsdottir, Karin M. A. Swart, Sian-Tsung Tan, Mark A. Tarnopolsky, Patricia Thompson, Cynthia A. Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J. Tranah, Jaakko Tuomilehto, Natasja M. van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N. Weedon, Ryan Welch, H.-Erich Wichmann, Elisabeth Widen, Frances M. K. Williams, James F. Wilson, Nicole C. Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C. Chambers, Angela Döring, Cornelia M. van Duijn, Michael J. Econs, Vilmundur Gudnason, Jaspal S. Kooner, Bruce M. Psaty, Timothy D. Spector, Kari Stefansson, Fernando Rivadeneira, André G. Uitterlinden, Nicholas J. Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J. F. Loos, David Karasik, Tamara B. Harris, Claes Ohlsson, Douglas P. Kiel

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be sig

Externí odkaz: https://doaj.org/article/c47ce1ff93954ef1b9d6bf1bf5948160

Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

Autor: Qiao Fan, Virginie J. M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Höhn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W. Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E. Huffman, Katie M. Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F. Wilson, Peter K. Joshi, George McMahon, Beate St Pourcain, David M. Evans, Claire L. Simpson, Tae-Hwi Schwantes-An, Robert P. Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kähönen, Ilkka Seppälä, Tanja Zeller, Thomas Meitinger, Janina S. Ried, Christian Gieger, Laura Portas, Elisabeth M. van Leeuwen, Najaf Amin, André G. Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R. Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M. Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E. H. Ho, Wan’e Lim, Roger W. Beuerman, Rosalynn Siantar, E-Shyong Tai, Eranga Vithana, Evelin Mihailov, Chiea-Chuen Khor, Caroline Hayward, Robert N. Luben, Paul J. Foster, Barbara E. K. Klein, Ronald Klein, Hoi-Suen Wong, Paul Mitchell, Andres Metspalu, Tin Aung, Terri L. Young, Mingguang He, Olavi Pärssinen, Cornelia M. van Duijn, Jie Jin Wang, Cathy Williams, Jost B. Jonas, Yik-Ying Teo, David A. Mackey, Konrad Oexle, Nagahisa Yoshimura, Andrew D. Paterson, Norbert Pfeiffer, Tien-Yin Wong, Paul N. Baird, Dwight Stambolian, Joan E. Bailey Wilson, Ching-Yu Cheng, Christopher J. Hammond, Caroline C. W. Klaver, Seang-Mei Saw, Consortium for Refractive Error and Myopia (CREAM)

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that at

Externí odkaz: https://doaj.org/article/b0563139c510416e9a4da61510e1f5d4