Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Janina Remy"'
Autor:
Carola Berking, Elisabeth Livingstone, Dirk Debus, Carmen Loquai, Michael Weichenthal, Ulrike Leiter, Felix Kiecker, Peter Mohr, Thomas K. Eigentler, Janina Remy, Katharina Schober, Markus V. Heppt, Imke von Wasielewski, Dirk Schadendorf, Ralf Gutzmer
Publikováno v:
Cancers, Vol 15, Iss 18, p 4436 (2023)
Combined BRAF/MEK-inhibition constitutes a relevant treatment option for BRAF-mutated advanced melanoma. The prospective, non-interventional COMBI-r study assessed the effectiveness and tolerability of the BRAF-inhibitor dabrafenib combined with the
Externí odkaz:
https://doaj.org/article/d06b1c350906457c9e3a32544876fb20
Autor:
Janina Remy, Benedikt Linder, Ulrike Weirauch, Bryan W. Day, Brett W. Stringer, Christel Herold-Mende, Achim Aigner, Knut Krohn, Donat Kögel
Publikováno v:
Cancers, Vol 14, Iss 2, p 339 (2022)
Glioblastoma (GBM) is a devastating disease and the most common primary brain malignancy of adults with a median survival barely exceeding one year. Recent findings suggest that the antipsychotic drug pimozide triggers an autophagy-dependent, lysosom
Externí odkaz:
https://doaj.org/article/d0fe7b9febb3444e9c9a95b0e6648345
Autor:
Vasile Sidorcenco, Luisa Krahnen, Marion Schulz, Janina Remy, Donat Kögel, Achim Temme, Ute Krügel, Heike Franke, Achim Aigner
Publikováno v:
Cancers, Vol 12, Iss 9, p 2707 (2020)
Glioblastomas (GBMs) are the most malignant brain tumors and are essentially incurable even after extensive surgery, radiotherapy, and chemotherapy, mainly because of extensive infiltration of tumor cells into the adjacent normal tissue. Thus, the ev
Externí odkaz:
https://doaj.org/article/32beb29731084c25845b263666949a03
Autor:
Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V. Mohrenz, Volker Seifert, Achim Aigner, Donat Kögel
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 7, Pp 564-573 (2015)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors.
Externí odkaz:
https://doaj.org/article/422273b6d3394659a937774385f82e3b
Autor:
Ulrike Weirauch, Rolf Marschalek, Donat Kögel, J. Konovalova, Janina Remy, Achim Aigner, Benedikt Linder
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:175-189
Overcoming apoptosis resistance is one major issue in glioblastoma (GB) therapies. Accumulating evidence indicates that resistance to apoptosis in GB is mediated via upregulation of pro-survival BCL2-family members. The synthetic BH3-mimetic ABT-737