Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.

Autor: Kim E Schmidt, Janina M Kuepper, Beatrix Schumak, Judith Alferink, Andrea Hofmann, Shanshan W Howland, Laurent Rénia, Andreas Limmer, Sabine Specht, Achim Hoerauf

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192717 (2018)

Malaria ranks among the most important infectious diseases worldwide and affects mostly people living in tropical countries. Mechanisms involved in disease progression are still not fully understood and specific treatments that might interfere with c

Externí odkaz: https://doaj.org/article/c26df7e621624b74b955920925eb7e54

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

Autor: Shanshan W. Howland, Sabine Specht, Kim E. Schmidt, Andrea Hofmann, Janina M. Kuepper, Achim Hoerauf, Andreas Limmer, Judith Alferink, Beatrix Schumak, Laurent Rénia

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192717 (2018)

Malaria ranks among the most important infectious diseases worldwide and affects mostly people living in tropical countries. Mechanisms involved in disease progression are still not fully understood and specific treatments that might interfere with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e16fafe856b01e3c2a197a3d210845b
http://europepmc.org/articles/PMC5811026

Specific Depletion of Ly6C(hi) Inflammatory Monocytes Prevents Immunopathology in Experimental Cerebral Malaria

Autor: Matthias Mack, Janina M. Kuepper, Nico van Rooijen, Beatrix Schumak, Andrea Djie-Maletz, Aindrila Biswas, Katrin Klocke, Andreas Limmer, Ildiko Rita Dunay, Achim Hoerauf

Publikováno v: PLoS ONE, 10(4):e0124080. Public Library of Science
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0124080 (2015)
Schumak, B, Klocke, K, Kuepper, J M, Biswas, A, Djie-Maletz, A, Limmer, A, van Rooijen, N, Mack, M, Hoerauf, A & Dunay, I R 2015, ' Specific Depletion of Ly6C(hi) Inflammatory Monocytes Prevents Immunopathology in Experimental Cerebral Malaria ', PLoS ONE, vol. 10, no. 4, e0124080 . https://doi.org/10.1371/journal.pone.0124080

Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice leads to experimental cerebral malaria (ECM) that is commonly associated with serious T cell mediated damage. In other parasitic infection models, inflammatory monocytes have been shown to regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5674572656dd41bcd10613ed136c550a
https://doi.org/10.1371/journal.pone.0124080