Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Janina Johänning"'
Autor:
Daniel, Stehle, Melanie, Grimm, Stephanie, Einsele-Scholz, Friederike, Ladwig, Janina, Johänning, Gerd, Fischer, Bernhard, Gillissen, Klaus, Schulze-Osthoff, Frank, Essmann
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functional
Autor:
Michel Eichelbaum, Astrid Nörenberg, Maria Thomas, Ulrich M. Zanger, Werner Schroth, Thomas E. Mürdter, Hiltrud Brauch, Matthias Schwab, Janina Johänning, Patrick Kröner
Publikováno v:
Archives of Toxicology
Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact.
Autor:
Georg Heinkele, Jana C. Precht, Matthias Schwab, Michel Eichelbaum, Hiltrud Brauch, Werner Schroth, Janina Johänning, Thomas E. Mürdter
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:7497-7502
Tamoxifen is a mainstay in the treatment of estrogen receptor-positive breast cancer and is metabolized to more than 30 different compounds. Little is known about in vivo concentrations of estrogenic metabolites E-metabolite E, Z-metabolite E, and bi
Autor:
Wolfgang Schmidt-Heck, Janina Johänning, Franziska Eplinius, Ute Hofmann, Albert M. Ricken, Christiane Rennert, Reinhardt Guthke, Madlen Matz-Soja, Rolf Gebhardt, Franziska Rolfs
Publikováno v:
Archives of toxicology. 91(11)
The Hedgehog signaling pathway is known to be involved in embryogenesis, tissue remodeling, and carcinogenesis. Because of its involvement in carcinogenesis, it seems an interesting target for cancer therapy. Indeed, Sonidegib, an approved inhibitor
Autor:
Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T. Daniel, Bernhard F. Gillissen, Klaus Schulze-Osthoff, Frank Essmann
Publikováno v:
Journal of cell science. 129(11)
The pro-apoptotic multidomain Bcl-2 proteins Bax and Bak (also known as BAK1) are considered the gatekeepers of the intrinsic pathway of apoptosis by triggering the mitochondrial release of cytochrome c The role of the third Bax- and Bak-homologous m
Autor:
Albert Braeuning, Eva Zeller, Ulrich M. Zanger, Michael Schwarz, Thomas S. Weiss, Maria Thomas, Werner Schroth, Janina Johänning, Silvia Vetter, Ute Hofmann, Barbara Petzuch
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(11)
Enzymatic conversion of most xenobiotic compounds is accomplished by hepatocytes in the liver, which are also an important target for the manifestation of the toxic effects of foreign compounds. Most cell lines derived from hepatocytes lack important
Autor:
Matthias Schwab, Werner Schroth, Janina Johänning, Thomas E. Mürdter, Diana Eccles, Hiltrud Brauch, Michel Eichelbaum, Bryony Eccles
Publikováno v:
Cancer Research. 76:2029-2029
Tamoxifen (Tam), a standard therapy for estrogen receptor (ER)-positive breast cancer, is excessively metabolized mainly by enzymes of the CYP450 family to anti-estrogenic and estrogenic compounds. Whereas in breast cancer cells the anti-estrogenic m