Výsledky vyhledávání - "Janina Grosch"

Akademický článek

Impact on the German asymptomatic screening strategy based on actual user data from SARS-CoV-2 test centers

Autor: Marcus Grohmann, Janina Grosch, Beate Conrady, Lena Schomakers, Anna Kristina Witte

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Since March 2021, Germany has been providing cost-free severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests, and many day-to-day activities following the lockdown have required negative test results. Yet it remains uncl

Externí odkaz: https://doaj.org/article/c38415731a224601a58de8d2b79bb1fa

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Akademický článek

Reduced bacterial contamination rates detected on silicone tourniquets compared to conventional tourniquets in clinical routine

Autor: Marcus Grohmann, Lena Schomakers, Frank Wolschendorf, Janina Grosch, Susan Lindner, Anna Kristina Witte

Publikováno v: BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-6 (2020)

Abstract Background Tourniquets used for peripheral venous vascular access such as blood sampling are regularly contaminated in clinical routine. Although most contaminations are harmless, some pose a possible risk for infection. To improve periphera

Externí odkaz: https://doaj.org/article/a784bfd4ecdd45bba587ae557339c06d

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Akademický článek

Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Autor: Markus Schulze, Annika Sommer, Sonja Plötz, Michaela Farrell, Beate Winner, Janina Grosch, Jürgen Winkler, Markus J. Riemenschneider

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-18 (2018)

Abstract Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based inf

Externí odkaz: https://doaj.org/article/9bc705bbdc794478a15e25e4938f2b62

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Free PoC Testing for SARS-CoV-2 in Germany: Factors Expanding Access to Various Communities in a Medium-Sized City

Autor: Anna Kristina Witte, Janina Grosch, Beate Conrady, Lena Schomakers, Marcus Grohmann

Publikováno v: International Journal of Environmental Research and Public Health; Volume 19; Issue 8; Pages: 4721
Witte, A K, Grosch, J, Conrady, B, Schomakers, L & Grohmann, M 2022, ' Free PoC Testing for SARS-CoV-2 in Germany: Factors Expanding Access to Various Communities in a Medium-Sized City ', International Journal of Environmental Research and Public Health, vol. 19, no. 8, pp. 4721 . https://doi.org/10.3390/ijerph19084721

During the third wave of the COVID-19 (coronavirus disease 2019) pandemic in Germany, free SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) point-of-care (PoC) antigen tests were offered to citizens at least once a week to prevent spreadi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447f78779c9dcb9a316ffb191c9be61a

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Reduced bacterial contamination rates detected on silicone tourniquets compared to conventional tourniquets in clinical routine

Autor: Susan Lindner, Frank Wolschendorf, Lena Schomakers, Anna Kristina Witte, Marcus Grohmann, Janina Grosch

Publikováno v: BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-6 (2020)
BMC Infectious Diseases

Background Tourniquets used for peripheral venous vascular access such as blood sampling are regularly contaminated in clinical routine. Although most contaminations are harmless, some pose a possible risk for infection. To improve peripheral venous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cdaaa0bd622df4b77c3d3315354074
http://link.springer.com/article/10.1186/s12879-020-04975-y

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Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice

Autor: Jürgen Winkler, Christian P. Müller, Janina Grosch, Jeanette Wihan, Liubov S. Kalinichenko, Zacharias Kohl

Publikováno v: Neurobiology of Aging. 80:29-37

Axonal pathology precedes dopaminergic cell loss in Parkinson's disease (PD), indicating a dying back axonopathy of nigrostriatal projections. Although most attention focused on the dopaminergic system, increasing evidence implies a compromised serot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fd9b1230f188124998a1f2fb725506
https://doi.org/10.1016/j.neurobiolaging.2019.03.014

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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

Autor: Wei Xiang, Christian Hannappel, Eliezer Masliah, Razvan-Marius Brazdis, Steven Havlicek, Katrin Simmnacher, André Reis, Iryna Prots, Mandy Krumbiegel, Vanesa Veber, Florian Krach, Beate Winner, Ursula Schlötzer-Schrehardt, Jürgen Winkler, Wolfgang Wrasidlo, Teja W. Groemer, Oliver Schütz, Janina Grosch, Douglas Galasko

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance α-Synuclein (α-Syn) aggregation underlies neurodegeneration in synucleinopathies. However, the nature of α-Syn aggregates and their toxic mechanisms in human pathology remains elusive. Here, we delineate a role of α-Syn oligomeric ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16af4e515c08777bbc70979ef1f4713b
https://doi.org/10.1073/pnas.1713129115

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Need for high-resolution genetic analysis in iPSC: results and lessons from the ForIPS consortium

Autor: Martin Regensburger, Mandy Krumbiegel, Steffen Uebe, Sonja Ploetz, Anita Rauch, Udo Trautmann, Arif B. Ekici, Frank Edenhofer, Katharina Günther, Annika Sommer, Beate Winner, Bernt Popp, Cornelia Kraus, Zacharias Kohl, André Reis, Michaela Farrell, Janina Grosch, Jürgen Winkler, Reza Asadollahi

Publikováno v: Scientific reports
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Genetic integrity of induced pluripotent stem cells (iPSCs) is essential for their validity as disease models and for potential therapeutic use. We describe the comprehensive analysis in the ForIPS consortium: an iPSC collection from donors with neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a1174c087161ef3c0f9230fa525275
http://gala.gre.ac.uk/id/eprint/36707/1/36707_ASADOLLAHI_Need_for_high_resolution.pdf

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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease

Autor: Jürgen Winkler, Daniela Graef, Fred H. Gage, Franz Marxreiter, Florian Krach, Michele Maroni, Wei Xiang, Iryna Prots, Markus J. Riemenschneider, Gene W. Yeo, Beate Winner, Esther Eberhardt, Annika Sommer, Zacharias Kohl, Janina Grosch, Tanja Fadler

Publikováno v: Cell stem cell. 23(1)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the adaptive immune system in PD. Here, we show a role for human T lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab59c5ce120df3a05bbc38b7e58399fd
https://pubmed.ncbi.nlm.nih.gov/31173705

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