An Arabidopsis FANCJ helicase homologue is required for DNA crosslink repair and rDNA repeat stability.

Autor: Annika Dorn, Laura Feller, Dominique Castri, Sarah Röhrig, Janina Enderle, Natalie J Herrmann, Astrid Block-Schmidt, Oliver Trapp, Laura Köhler, Holger Puchta

Publikováno v: PLoS Genetics, Vol 15, Iss 5, p e1008174 (2019)

Proteins of the Fanconi Anemia (FA) complementation group are required for crosslink (CL) repair in humans and their loss leads to severe pathological phenotypes. Here we characterize a homolog of the Fe-S cluster helicase FANCJ in the model plant Ar

Externí odkaz: https://doaj.org/article/c469bead6bac47e08a8fa8956a334265

The DNA-dependent protease AtWSS1A suppresses persistent double strand break formation during replication

Autor: Niklas Capdeville, Laura Feller, Janina Enderle-Kukla, Holger Puchta, Annika Dorn, Leonie Hacker

Publikováno v: New Phytologist, 233 (3), 1172-1187

The protease WSS1A is an important factor in the repair of DNA-protein crosslinks in plants. Here we show that the loss of WSS1A leads to a reduction of 45S rDNA repeats and chromosomal fragmentation in Arabidopsis. Moreover, in the absence of any fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aaf018af1d2f3a1f1a51667a94e4a8
https://pubmed.ncbi.nlm.nih.gov/34761387

DNA- and DNA-Protein-Crosslink Repair in Plants

Autor: Janina Enderle, Annika Dorn, Holger Puchta

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences, 20 (17), Article: 4304
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4304 (2019)

DNA-crosslinks are one of the most severe types of DNA lesions. Crosslinks (CLs) can be subdivided into DNA-intrastrand CLs, DNA-interstrand CLs (ICLs) and DNA-protein crosslinks (DPCs), and arise by various exogenous and endogenous sources. If left

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9618a74e672d091312e6ed591bde0e2
https://pubmed.ncbi.nlm.nih.gov/31484324

The RecQ-like helicase HRQ1 is involved in DNA crosslink repair in Arabidopsis in a common pathway with the Fanconi anemia-associated nuclease FAN1 and the postreplicative repair ATPase RAD5A

Autor: Janina Enderle, Alexander Knoll, Angelina Schindele, Holger Puchta, Annika Dorn, Natalie J. Herrmann, Sarah Röhrig

Publikováno v: The new phytologist, 218 (4), 1478–1490
New Phytologist

RecQ helicases are important caretakers of genome stability and occur in varying copy numbers in different eukaryotes. Subsets of RecQ paralogs are involved in DNA crosslink (CL) repair. The orthologs of AtRECQ2, AtRECQ3 and AtHRQ1, HsWRN, DmRECQ5 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e74b5b92ff5ccc1926539eb91fd1fc
https://publikationen.bibliothek.kit.edu/1000090926/75638877