Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Janina Dose"'
Autor:
Alexander Immel, Federica Pierini, Christoph Rinne, John Meadows, Rodrigo Barquera, András Szolek, Julian Susat, Lisa Böhme, Janina Dose, Joanna Bonczarowska, Clara Drummer, Katharina Fuchs, David Ellinghaus, Jan Christian Kässens, Martin Furholt, Oliver Kohlbacher, Sabine Schade-Lindig, Andre Franke, Stefan Schreiber, Johannes Krause, Johannes Müller, Tobias L. Lenz, Almut Nebel, Ben Krause-Kyora
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Alexander Immel et al. performed genome-wide analyses of 42 individuals from a collective burial in Niedertiefenbach, Germany from the Wartberg Culture. The authors find that this population had a large hunter-gatherer ancestry component and a distin
Externí odkaz:
https://doaj.org/article/717976e7bf6b47afb826711305978671
Autor:
Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival perc
Externí odkaz:
https://doaj.org/article/43040ac329044c8a980e87b5849d94cd
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and
Externí odkaz:
https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0
Autor:
Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22613-2
Externí odkaz:
https://doaj.org/article/22274fdaa9da45edb97a7c76d79337dd
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The original version of this Article contained an error in the spelling of the author Robert Häsler, which was incorrectly given as Robert Häesler. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/3a301166958a4d53891142c0787acc2f
Autor:
Daniel Kolbe, Nicolas A. da Silva, Janina Dose, Guillermo G. Torres, Amke Caliebe, Ben Krause‐Kyora, Almut Nebel
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9680c5efbc47719e978d9e542e2cfdd
https://doi.org/10.1111/acel.13819
https://doi.org/10.1111/acel.13819
Autor:
Ben Krause-Kyora, Guillermo Torres, Nicolas da Silva, Daniel Kolbe, Janina Dose, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Amke Caliebe, Johannes Müller, Stefan Schreiber, Almut Nebel
Inflammatory bowel disease (IBD) is often described as a model for modern civilization diseases in which environmental factors trigger disease manifestation in genetically compromised individuals. Little is known about the evolutionary history of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec34ca8a97f076bc3b4422c3d0335a4
https://doi.org/10.21203/rs.3.rs-2075746/v1
https://doi.org/10.21203/rs.3.rs-2075746/v1
Autor:
Martina Müller-Nurasyid, Markus M. Nöthen, Friederike Flachsbart, Annette Peters, Kaare Christensen, Sophie Chantalat, Stefan Schreiber, David Ellinghaus, Pilar Galan, Per Hoffmann, Almut Nebel, Lene Christiansen, Amke Caliebe, Hélène Blanché, Andre Franke, Konstantin Strauch, Marianne Nygaard, Wolfgang Lieb, Janina Dose, Guillermo G. Torres, Jean-François Deleuze
Publikováno v:
Torres, G G, Nygaard, M, Caliebe, A, Blanché, H, Chantalat, S, Galan, P, Lieb, W, Christiansen, L, Deleuze, J-F, Christensen, K, Strauch, K, Müller-Nurasyid, M, Peters, A, Nöthen, M M, Hoffmann, P, Flachsbart, F, Schreiber, S, Ellinghaus, D, Franke, A, Dose, J & Nebel, A 2021, ' Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 76, no. 5, pp. 786-795 . https://doi.org/10.1093/gerona/glab023
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
J. Gerontol. A Biol. Sci. Med. Sci. 76, 786–795 (2021)
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
J. Gerontol. A Biol. Sci. Med. Sci. 76, 786–795 (2021)
Despite enormous research efforts, the genetic component of longevity has remained largely elusive. The investigation of common variants, mainly located in intronic or regulatory regions, has yielded only little new information on the heritability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5a3bc1e877f0288d7b9ee198e90b2f
https://doi.org/10.1093/gerona/glab023
https://doi.org/10.1093/gerona/glab023
Autor:
Tobias L. Lenz, Frederica Pierini, Lisa Böhme, Joanna H. Bonczarowska, Janina Dose, Almut Nebel, Johannes Müller, Sabine Schade-Lindig, Rodrigo Barquera, Clara Drummer, Oliver Kohlbacher, Alexander Immel, Andre Franke, Martin Furholt, John Meadows, Julian Susat, David Ellinghaus, András Szolek, Stefan Schreiber, Christoph Rinne, Katharina Fuchs, Jan Christian Kässens, Ben Krause-Kyora, Johannes Krause
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Communications Biology
Communications Biology
The Wartberg culture (WBC, 3500-2800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We performed genome-wide analyses of 42 individuals who were interred in a WBC collective bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eddd1abc494ae8e5b6defbb6c8c4dc
https://doaj.org/article/717976e7bf6b47afb826711305978671
https://doaj.org/article/717976e7bf6b47afb826711305978671
Autor:
Wolfgang Lieb, Friederike Flachsbart, Femke-Anouska Heinsen, Paul Datlinger, Wolfram Klapper, Jonas Mengel-From, Andre Franke, Janina Dose, Silke Szymczak, Almut Nebel, Stefan Schreiber, Geetha Venkatesh, Robert Häsler, Christoph Bock, Guillermo G. Torres, Marianne Nygaard, Kaare Christensen
Publikováno v:
Human Molecular Genetics
Szymczak, S, Dose, J, Torres, G G, Heinsen, F-A, Venkatesh, G, Datlinger, P, Nygaard, M, Mengel-From, J, Flachsbart, F, Klapper, W, Christensen, K, Lieb, W, Schreiber, S, Häsler, R, Bock, C, Franke, A & Nebel, A 2020, ' DNA methylation QTL analysis identifies new regulators of human longevity ', Human Molecular Genetics, vol. 29, no. 7, pp. 1154-1167 . https://doi.org/10.1093/hmg/ddaa033
Szymczak, S, Dose, J, Torres, G G, Heinsen, F-A, Venkatesh, G, Datlinger, P, Nygaard, M, Mengel-From, J, Flachsbart, F, Klapper, W, Christensen, K, Lieb, W, Schreiber, S, Häsler, R, Bock, C, Franke, A & Nebel, A 2020, ' DNA methylation QTL analysis identifies new regulators of human longevity ', Human Molecular Genetics, vol. 29, no. 7, pp. 1154-1167 . https://doi.org/10.1093/hmg/ddaa033
Human longevity is a complex trait influenced by both genetic and environmental factors, whose interaction is mediated by epigenetic mechanisms like DNA methylation. Here, we generated genome-wide whole-blood methylome data from 267 individuals, of w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6724c380dfad45d3f3bc4563718720ea
https://doi.org/10.1093/hmg/ddaa033
https://doi.org/10.1093/hmg/ddaa033