Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Janin Lautenschläger"'
Autor:
Janin Lautenschläger
Publikováno v:
Open Biology, Vol 12, Iss 2 (2022)
Fundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling. However, certain regulatory steps still remain inc
Externí odkaz:
https://doaj.org/article/7db2152dd0454d738f32654792768bee
Autor:
Janin Lautenschläger, Amberley D. Stephens, Giuliana Fusco, Florian Ströhl, Nathan Curry, Maria Zacharopoulou, Claire H. Michel, Romain Laine, Nadezhda Nespovitaya, Marcus Fantham, Dorothea Pinotsi, Wagner Zago, Paul Fraser, Anurag Tandon, Peter St George-Hyslop, Eric Rees, Jonathan J. Phillips, Alfonso De Simone, Clemens F. Kaminski, Gabriele S. Kaminski Schierle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle c
Externí odkaz:
https://doaj.org/article/70d12e9421354902991a3d31fd154a54
Autor:
Janin Lautenschläger, Eugene V. Mosharov, Ellen Kanter, David Sulzer, Gabriele S. Kaminski Schierle
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Postnatally derived cultures of ventral mesencephalic neurons offer several crucial advantages over embryonic ventral mesencephalic cultures, including a higher content of TH-positive cells and the ability to derive cells from the substantia nigra, w
Externí odkaz:
https://doaj.org/article/8537b2004bf44f6a9240aff5ad4b24b3
Autor:
Ana Fernández-Villegas, Gabriele S. Kaminski Schierle, Marcus Fantham, Janin Lautenschläger, Amberley D. Stephens, Sara Wagner-Valladolid, James D. Manton, Eric J. Rees, Colin Hockings, Ajay Kumar Mishra, Clemens F. Kaminski, Meng Lu
Publikováno v:
The Journal of Biological Chemistry
Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkinson's disease (PD); however, it is unclear how mitochondrial impairment and α-synuclein pathology are coupled. Using specific mitochondrial inhibitors, EM ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7e7eeeea451c96a4055d8c3caf92ea
http://europepmc.org/articles/PMC7383368
http://europepmc.org/articles/PMC7383368
Publikováno v:
Trends in Cell Biology. 27:468-479
α-Synuclein is known as a presynaptic protein that binds to small synaptic vesicles. Recent studies suggest that α-synuclein is not only attracted to these tiny and therewith highly curved membranes, but that in fact the sensing and regulation of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a1ef47aa3eac360361e844b7c1f114
https://doi.org/10.1016/j.tcb.2017.02.002
https://doi.org/10.1016/j.tcb.2017.02.002
Autor:
Julia Ruhmer, Janin Lautenschläger, Tino Prell, Otto W. Witte, Julian Grosskreutz, Lisa Weidemann
Publikováno v:
Experimental Neurology. 247:91-100
Motor neurons vulnerable to the rapidly progressive deadly neurodegenerative disease amyotrophic lateral sclerosis (ALS) inherently express low amounts of calcium binding proteins (CaBP), likely to allow physiological motor neuron firing frequency mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b21c98f3477da47d89052473ff70155
https://doi.org/10.1016/j.expneurol.2013.03.027
https://doi.org/10.1016/j.expneurol.2013.03.027
Publikováno v:
Cell Calcium. 54:132-143
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by a progressive loss of motor neurons. Although the etiology remains unclear, disturbances in Ca2+ homoeostasis and protein folding are essential features of neurodegeneratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e7dd737ddbc6d1899e91ff446d8df8
https://doi.org/10.1016/j.ceca.2013.05.007
https://doi.org/10.1016/j.ceca.2013.05.007
Publikováno v:
European Journal of Neuroscience. 35:652-660
Recent studies indicate that endoplasmic reticulum (ER) stress is involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS). ER stress occurs when the ER-mitochondria calcium cycle (ERMCC) is disturbed and misfolded pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ac46f8a7eeed98e6fe1d343899495d
https://doi.org/10.1111/j.1460-9568.2012.08008.x
https://doi.org/10.1111/j.1460-9568.2012.08008.x
Publikováno v:
Proteomics. Clinical applications. 7(1-2)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of motor neurons leading to death of the patients, mostly within 2-5 years after disease onset. The pathomechanism of motor neuron degeneration is only partially understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37671db0e574846f7365368f3ab2165
https://pubmed.ncbi.nlm.nih.gov/23129563
https://pubmed.ncbi.nlm.nih.gov/23129563