Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Janin Chandra"'
Autor:
Rahul Ladwa, Janin Chandra, Wai-Ping Woo, Neil Finlayson, Howard Liu, Margaret McGrath, Adrienne See, Brett G. Hughes, Caroline L. Cooper, Jim E. Jackson, Marcin Dzienis, Yan Xu, Benedict Panizza, Ian Frazer, Sandro V. Porceddu
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundProgrammed cell death ligand 1 (PD-L1) inhibitors have limited efficacy as monotherapy in patients with recurrent/metastatic (R/M) Human Papilloma Virus (HPV) oropharyngeal squamous cell carcinoma (OPSCC). A phase I study of the therapeutic
Externí odkaz:
https://doaj.org/article/fb7a6deac1ce446d93ed6b6a8082e5ce
Autor:
Jacoba I. Bromfield, Julian Zaugg, Rodney C. Straw, Julia Cathie, Annika Krueger, Debottam Sinha, Janin Chandra, Philip Hugenholtz, Ian H. Frazer
Publikováno v:
mSphere, Vol 9, Iss 4 (2024)
ABSTRACTHuman cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) display microbial dysbiosis with an enrichment of staphylococcal species, which have been implicated in AK and SCC progression. SCCs are common in both felines and can
Externí odkaz:
https://doaj.org/article/88ccea17fe92471c8c7559ba9a726bf6
Autor:
Sachin Muralidharan, Sarah Ali, Lilin Yang, Joshua Badshah, Syeda Farah Zahir, Rubbiya A. Ali, Janin Chandra, Ian H. Frazer, Ranjeny Thomas, Ahmed M. Mehdi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The purpose of this study is to manually and semi-automatically curate a database and develop an R package that will act as a comprehensive resource to understand how biological processes are dysregulated due to interactions with environment
Externí odkaz:
https://doaj.org/article/52a0e459a18d46ae9f5a69950f8efc7f
Autor:
Jacoba Isobella Bromfield, Philip Hugenholtz, Ian Hector Frazer, Kiarash Khosrotehrani, Janin Chandra
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Cutaneous squamous cell carcinoma (cSCC) and its premalignant precursor, actinic keratosis (AK), present a global health burden that is continuously increasing despite extensive efforts to promote sun safety. Chronic UV exposure is a recognized risk
Externí odkaz:
https://doaj.org/article/0c071ca13b0f4352997ce3caad3e0ae1
Autor:
Janin Chandra, Morten Hansen, Nathalie Labarriere, Ilaria Marigo, Fernando Souza-Fonseca-Guimaraes, Lazar Vujanovic, Yoshinobu Koguchi, Nicolas Jacquelot
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/887d1623bc2b4c4a954c89a2dce4ed11
Autor:
Inga Rødahl, James Gotley, Stacey B. Andersen, Meihua Yu, Ahmed M. Mehdi, Angelika N. Christ, Emma E. Hamilton-Williams, Ian H. Frazer, Samuel W. Lukowski, Janin Chandra
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100842- (2021)
Summary: Here, we outline detailed protocols to isolate and profile murine splenic dendritic cells (DCs) through advanced flow cytometry of the myeloid compartment and single-cell transcriptomic profiling with integrated cell surface protein expressi
Externí odkaz:
https://doaj.org/article/bc293b82d9af4ba9b44accdf4fcffa02
Autor:
Zewen K. Tuong, Samuel W. Lukowski, Quan H. Nguyen, Janin Chandra, Chenhao Zhou, Kevin Gillinder, Abate A. Bashaw, John R. Ferdinand, Benjamin J. Stewart, Siok Min Teoh, Sarah J. Hanson, Katharina Devitt, Menna R. Clatworthy, Joseph E. Powell, Ian H. Frazer
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103326- (2021)
Summary: Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune responses to epithelial microorganisms. Human papillomavirus (HPV) infection can promote malignant epithelial transformation. As LCs are considered importa
Externí odkaz:
https://doaj.org/article/08f0ec2087624af0b1807e9af63d460a
Autor:
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102402- (2021)
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-ass
Externí odkaz:
https://doaj.org/article/d40a660dfb404f28a5f14a6069e10f15
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Background: Limited immunotherapy options are approved for the treatment of cervical cancer and only 10–25% of patients respond effectively to checkpoint inhibition monotherapy. To aid the development of novel therapeutic immune targets, we aimed t
Externí odkaz:
https://doaj.org/article/accc772abf5b4eab90bc427ae06ec0c2
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Human papillomavirus (HPV) infection is associated with a range of malignancies that affect anogenital and oropharyngeal sites. α-HPVs dominantly infect basal epithelial cells of mucosal tissues, where they dysregulate cell division and local immuni
Externí odkaz:
https://doaj.org/article/cc63526bfa5b4ac2a4995ceea9960333