Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Janin Berndt"'
Autor:
Anke Tönjes, Jana Breitfeld, Peter Kovacs, Stefan Engeli, Nora Klöting, Yvonne Böttcher, Matthias Blüher, B. Enigk, Michael Stumvoll, Janin Berndt, Dorit Schleinitz, Kerstin Dietrich, I Müller, G. H. Scholz, Solveig Carmienke
Publikováno v:
Pharmacogenomics. 11:693-702
Aims: The endocannabinoid system may contribute to the association of visceral fat accumulation with metabolic diseases. Here we investigated the effects of genetic variation in the cannabinoid type 1 receptor gene (CNR1) on its mRNA expression in ad
Autor:
Nora Klöting, Karen Ruschke, Peter Kovacs, Michael Stumvoll, Janin Berndt, Antje Körner, Matthias Blüher, Mathias Fasshauer, Michael R. Schön
Publikováno v:
Diabetologia. 50:1472-1480
Increased expression and activity of the lipogenic pathways in adipose tissue may contribute to the development of obesity. As a central enzyme in lipogenesis, the gene encoding fatty acid synthase (FASN) was identified as a candidate gene for determ
Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity
Autor:
Michael Stumvoll, Janin Berndt, Matthias Blüher, Mathias Fasshauer, Stefan Engeli, Pal Pacher, Michael R. Schön, Nora Klöting, Jens Jordan, Sandor Batkai
Publikováno v:
Diabetes. 55:3053-3060
The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. We determined whether circulating endocannabinoids are related to visceral adipose tissue mass in lean, subcutaneous
Autor:
Matthias Blüher, Wieland Kiess, B. Enigk, Anke Tönjes, Marlene Reichenbächer, Peter Kovacs, Karen Ruschke, Michael Stumvoll, Janin Berndt, Yvonne Böttcher, Michael R. Schön, Jost Jenkner, Matthias Filz, Nora Klöting, Dorit Schleinitz, Kerstin Dietrich, Antje Körner
Publikováno v:
Obesity (Silver Spring, Md.). 18(6)
Inhibition of fatty acid synthase (FASN) induces a rapid decline in fat stores in mice, suggesting a role for this enzyme in energy homeostasis. To investigate the potential role of FASN in the pathophysiology of human obesity, the FASN gene was sequ
Autor:
Kerstin Dietrich, Y. H. Tseng, Matthias Blüher, G. H. Scholz, B. Enigk, Karen Ruschke, S. Wolf, Michael Stumvoll, Janin Berndt, Peter Kovacs, A Tönjes, Dorit Schleinitz, Yvonne Böttcher, Moritz Koriath, Nora Klöting
Publikováno v:
Diabetologie und Stoffwechsel. 4
Autor:
Michael R. Schön, Matthias Kern, Susan Kralisch, Nora Klöting, Matthias Blüher, Mathias Fasshauer, Karen Ruschke, Michael Stumvoll, Janin Berndt
Publikováno v:
Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 116(4)
In comparison to subcutaneous (SC) fat, visceral adipose tissue is more sensitive to catecholamine-induced lipolysis and less sensitive to the antilipolytic effects of insulin. Variation in the expression of lipoprotein lipase (LPL) and hormone-sensi
Autor:
Matthias Blüher, Peter Kovacs, Karen Ruschke, Michael Stumvoll, Michael R. Schön, Janin Berndt, Nora Klöting, Antje Körner
Publikováno v:
Metabolism: clinical and experimental. 57(9)
Variants in the TCF7L2 gene have been associated with type 2 diabetes mellitus (T2DM), but the causal variant(s) is still unknown. We studied the TCF7L2 messenger RNA (mRNA) expression in paired samples of visceral and subcutaneous adipose tissue fro
Autor:
Matthias Blüher, Mathias Fasshauer, Peter Kovacs, Karen Ruschke, Michael Stumvoll, Janin Berndt, Michael R. Schön, Anke Tönjes, Dorit Schleinitz, Nora Klöting
Publikováno v:
Diabetologia. 51(4)
Recently, FTO was identified as a candidate gene contributing to both childhood and severe adult obesity. We tested the hypothesis that mRNA expression of FTO and/or of the neighbouring RPGRIP1L in adipose tissue correlates with measures of obesity a
Autor:
Catherine J. Williams, Alex Hsi, Nora Klöting, Christos S. Mantzoros, Michael R. Schön, Alicja Wolk, Karen Ruschke, Michael Stumvoll, Janin Berndt, Andreas Oberbach, Matthias Blüher, Mathias Fasshauer
Publikováno v:
Diabetes care. 30(12)
OBJECTIVE—Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively) mediate the effects of adiponectin on glucose and lipid metabolism in vivo. We examined whether AdipoR1 and/or AdipoR2 mRNA expression in human adipose tissue is fat-depot
Autor:
Michael R. Schön, Peter Kovacs, Dorit Schleinitz, Michaela Geyer, Anke Tönjes, Yvonne Böttcher, Nora Klöting, Michael Stumvoll, Janin Berndt, Matthias Blüher, B. Enigk, Timothy E. Graham, Barbara B. Kahn
Publikováno v:
Diabetes. 56(12)
OBJECTIVE— Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes.