Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Janika Viereck"'
Autor:
Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatterjee, Xiaoke Yin, Christian Bär, Manuel Mayr, Ke Xiao, Thomas Thum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine
Externí odkaz:
https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d2
Autor:
Sandor Batkai, Katrin Zlabinger, Janika Viereck, Johannes Winkler, Martin Riesenhuber, Denise Traxler, Sonja Neitzel, Dominika Lukovic, Rita Garamvölgyi, Tobias Borchert, Celina Genschel, Thomas Thum, Mariann Gyöngyösi, Ena Hasimbegovic, Andreas Spannbauer, Christian Bär, Steffen Rump
Publikováno v:
European Heart Journal
Aims Cardiac miR-132 activation leads to adverse remodelling and pathological hypertrophy. CDR132L is a synthetic lead-optimized oligonucleotide inhibitor with proven preclinical efficacy and safety in heart failure (HF) early after myocardial infarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491df15c0eabbf1acb089682f0499c8a
https://doi.org/10.1093/eurheartj/ehaa791
https://doi.org/10.1093/eurheartj/ehaa791
Autor:
Laura Rode, Christian Bär, Sonja Groß, Axel Rossi, Nadja Meumann, Janika Viereck, Naisam Abbas, Ke Xiao, Isabelle Riedel, Anika Gietz, Karina Zimmer, Margarete Odenthal, Hildegard Büning, Thomas Thum
AAV vectors are promising delivery tools for human gene therapy. However, broad tissue tropism and pre-existing immunity against natural serotypes limit their clinical use. We identified two AAV capsid variants, AAV2-THGTPAD and AAV2-NLPGSGD, by in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e13d84fce31658a1d299a9e1063424
https://publica.fraunhofer.de/handle/publica/429675
https://publica.fraunhofer.de/handle/publica/429675
Autor:
Henning Weigt, Thomas Thum, Celina Genschel, Carmen Theek, Sandor Batkai, Jorg Taubel, Wilfried Hauke, L Rode, Janika Viereck, Ulrike Lorch, Steffen Rump, Scott D. Solomon, Arthur A. Levin, Jenny Poetzsch, Johann Bauersachs
Publikováno v:
European Heart Journal. 42
Background Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is a first-in-class miR-132 inhibitor that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b365775ba88ccc4f41b7e9d94bb90ff6
https://doi.org/10.1093/eurheartj/ehab724.0920
https://doi.org/10.1093/eurheartj/ehab724.0920
Autor:
Carmen Theek, Janika Viereck, Wilfried Hauke, Jorg Taubel, Rode Laura, Johann Bauersachs, Poetzsch Jenny, Arthur A. Levin, Sandor Batkai, Steffen Rump, Henning Weigt, Thomas Thum, Celina Genschel, Ulrike Lorch, Scott D. Solomon
Publikováno v:
Circulation Research. 129
Cardiac microRNA-132-3p (miR-132) levels are elevated in people suffering with heart failure (HF) and mechanistically drive remodelling processes in the heart. Here we present CDR132L, a specific antisense oligonucleotide. It is a first-in-class miR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4cc2e6c73fb8a91e22c55713cdcf51
https://doi.org/10.1161/res.129.suppl_1.114
https://doi.org/10.1161/res.129.suppl_1.114
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction
Autor:
Tobias Borchert, Christian Kupatt, Christian Weber, Markus Sperandio, Stefan Engelhardt, Sarah Straub, Tilman Ziegler, Franz Freudenthal, Sandor Batkai, Tarik Bozoglu, Karl-Ludwig Laugwitz, Lisa Oberberger, Alessandra Moretti, Victoria Jurisch, Andrea Bähr, Janika Viereck, Andrea Howe, Rabea Hinkel, Nadja Hornaschewitz, Nik Klymiuk, Thomas Thum, Rainer Kozlik-Feldmann
Publikováno v:
Journal of the American College of Cardiology. 77(23)
Background Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive adverse cardiac remodeling, myocardial dysfunction, capillary rarefaction, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f2d0525a9074f6a535363f47b77e34
https://pubmed.ncbi.nlm.nih.gov/34155375
https://pubmed.ncbi.nlm.nih.gov/34155375
Autor:
Michaela Scherr, Eline Feyen, Denise Hilfiker-Kleiner, Janika Viereck, Gilles W. De Keulenaer, Jens Van Fraeyenhove, Melanie Ricke-Hoch, Vincent F.M. Segers, Zarha Vermeulen, Lindsey Dugaucquier, Thomas Thum, Tine Bruyns
Publikováno v:
Circulation : heart failure
Background: Peripartum cardiomyopathy (PPCM) is a life-threatening disease in women without previously known cardiovascular disease. It is characterized by a sudden onset of heart failure before or after delivery. Previous studies revealed that the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a54e40d5bc29d03b809acfbe0a6708
https://hdl.handle.net/10067/1803990151162165141
https://hdl.handle.net/10067/1803990151162165141
Autor:
Arthur A. Levin, Wilfried Hauke, Johann Bauersachs, Janika Viereck, Carmen Theek, Jorg Taubel, Sandor Batkai, Henning Weigt, Ulrike Lorch, Jenny Poetzsch, Thomas Thum, Steffen Rump, Scott D. Solomon, Celina Genschel, Laura Rode
Publikováno v:
Eur Heart J
Aims Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is a first-in-class miR-132 inhibitor that attenua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9fc33d22ac80be6240b19573df4532
https://pubmed.ncbi.nlm.nih.gov/33338200
https://pubmed.ncbi.nlm.nih.gov/33338200
Autor:
Andreas Pich, Johanna Christine Jansing, Christian Mühlfeld, Janika Viereck, Christina Brandenberger, Thomas Thum, Jan Fiedler
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 822 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences
Volume 21
Issue 3
Acute lung injury (ALI) is characterized by enhanced permeability of the air&ndash
blood barrier, pulmonary edema, and hypoxemia. MicroRNA-21 (miR-21) was shown to be involved in pulmonary remodeling and the pathology of ALI, and we hypothesized
blood barrier, pulmonary edema, and hypoxemia. MicroRNA-21 (miR-21) was shown to be involved in pulmonary remodeling and the pathology of ALI, and we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb605bada0d5425c88f2c4b2a381476
https://www.mdpi.com/1422-0067/21/3/822
https://www.mdpi.com/1422-0067/21/3/822
Autor:
Thomas Thum, Sabine Samolovac, Ariana Foinquinos, Shashi Kumar Gupta, Freya Luise Kramer, Karina Zimmer, Janika Viereck, Sandor Batkai, Maria-Teresa Piccoli, Ankita Garg, Janet Remke
Publikováno v:
Circulation Research. 121:575-583
Rationale: Cardiac fibroblasts (CFs) drive extracellular matrix remodeling after pressure overload, leading to fibrosis and diastolic dysfunction. Recent studies described the role of long noncoding RNAs (lncRNAs) in cardiac pathologies. Nevertheless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f38c30362e5e4a7e70e9e6865ec542
https://doi.org/10.1161/circresaha.117.310624
https://doi.org/10.1161/circresaha.117.310624