Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Janik Weckesser"'
Autor:
Martin P. Schwalm, Andreas Krämer, Anja Dölle, Janik Weckesser, Xufen Yu, Jian Jin, Krishna Saxena, Stefan Knapp
The multistep PROTAC (PROteolysis TArgeting Chimeras) degradation process poses challenges for their rational development, as rate limiting steps determining PROTAC efficiency remain largely unknown. Moreover, the slow throughput of currently used en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80077b70c79e7ef0e64344b2fba8ddc8
https://doi.org/10.1101/2023.01.11.523589
https://doi.org/10.1101/2023.01.11.523589
Autor:
Jennifer A. Amrhein, Tyler S. Beyett, William W. Feng, Andreas Krämer, Janik Weckesser, Ilse K. Schaeffner, Jaimin K. Rana, Pasi A. Jänne, Michael J. Eck, Stefan Knapp, Thomas Hanke
Publikováno v:
Journal of medicinal chemistry. 65(23)
Activating mutations in the epidermal growth factor receptor (EGFR) are frequent oncogenic drivers of non-small-cell lung cancer (NSCLC). The most frequent alterations in EGFR are short in-frame deletions in exon 19 (Del19) and the missense mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a573eba1b01ecc072fffddc210d61c
https://pubmed.ncbi.nlm.nih.gov/36384036
https://pubmed.ncbi.nlm.nih.gov/36384036
Autor:
Jelena Bozilovic, Lorenz Eing, Benedict-Tilman Berger, Bikash Adhikari, Janik Weckesser, Nicola B. Berner, Stephanie Wilhelm, Bernhard Kuster, Elmar Wolf, Stefan Knapp
The family of AURORA kinases is essential for cell cycle progression and dysregulation of AURORA-A in cancer led to a large number of clinical and pre-clinical inhibitors. However, ATP competitive AURORA-A inhibitors usually do not target non-catalyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e20e8aba0daab34399ed3f2f585913
Autor:
Andreas Krämer, Elmar Wolf, Frank Löhr, Dalia Barsyte-Lovejoy, Martin Eilers, Mathias Diebold, Magdalena M. Szewczyk, Christoph A. Sotriffer, Cheryl H. Arrowsmith, Lena-Marie Berger, Stephanie Heinzlmeir, Jakob Gebel, Bernhard Kuster, Volker Dötsch, Stefan Knapp, Bikash Adhikari, Anja Dölle, Janik Weckesser, Nicola Berner
Publikováno v:
Journal of Medicinal Chemistry
Histone H3K4 methylation serves as a post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferase (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat-containing protein 5 (WDR5) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9b410f43fdcefc8cfce34921fe7cbe