Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.

Autor: Radwitz J; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany., Hausrat TJ; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany., Heisler FF; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany., Janiesch PC; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany., Pechmann Y; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany., Rübhausen M; Institut für Nanostruktur- und Festkörperphysik, Center for Free Electron Laser Science (CFEL), University of Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Kneussel M; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany. matthias.kneussel@zmnh.uni-hamburg.de.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Oct 29; Vol. 79 (11), pp. 575. Date of Electronic Publication: 2022 Oct 29.

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.

Autor: Reinicke AT; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Laban K; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Sachs M; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Kraus V; Behavioral Biology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Walden M; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Damme M; Institute of Biochemistry, Christian Albrechts University Kiel, 24118 Kiel, Germany., Sachs W; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Reichelt J; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schweizer M; Center for Molecular Neurobiology Hamburg, Morphology and Electron Microscopy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Janiesch PC; Neuronal Translational Control Research Group, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Duncan KE; Neuronal Translational Control Research Group, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Saftig P; Institute of Biochemistry, Christian Albrechts University Kiel, 24118 Kiel, Germany., Rinschen MM; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.; Center for Mass Spectrometry and Metabolomics, The Scripps Research Institute, La Jolla, CA 92037., Morellini F; Behavioral Biology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; c.meyer-schwesinger@uke.uni-hamburg.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 16; Vol. 116 (16), pp. 7963-7972. Date of Electronic Publication: 2019 Mar 28.

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.

Autor: Tărlungeanu DC; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria., Deliu E; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria., Dotter CP; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria., Kara M; Department of Pediatrics, Tripoli Children's Hospital, Tripoli, Libya., Janiesch PC; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg 20251, Germany., Scalise M; Department DiBEST, Unit of Biochemistry & Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy., Galluccio M; Department DiBEST, Unit of Biochemistry & Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy., Tesulov M; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria., Morelli E; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria., Sonmez FM; Association of Developmental Child Neurology, Ankara, Turkey., Bilguvar K; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Center for Genome Analysis, Yale School of Medicine, Orange, CT 06477, USA., Ohgaki R; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka Prefecture 565-0871, Japan., Kanai Y; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka Prefecture 565-0871, Japan., Johansen A; Department of Neuroscience, UCSD, Investigator, Howard Hughes Medical Institute, Rady Children's Institute for Genomic Medicine, San Diego, CA 92093, USA., Esharif S; Department of Pediatrics, Tripoli Children's Hospital, Tripoli, Libya., Ben-Omran T; Section of Clinical and Metabolic Genetics, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar., Topcu M; Department of Pediatric Neurology, Hacettepe University Children's Hospital, Ankara, Turkey., Schlessinger A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Indiveri C; Department DiBEST, Unit of Biochemistry & Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy., Duncan KE; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg 20251, Germany., Caglayan AO; Department of Medical Genetics, School of Medicine, Istanbul Bilim University, Istanbul, Turkey; Departments of Neurosurgery, Genetics, and Neurobiology, Program in Brain Tumor Research, Yale Program on Neurogenetics and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA., Gunel M; Departments of Neurosurgery, Genetics, and Neurobiology, Program in Brain Tumor Research, Yale Program on Neurogenetics and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA., Gleeson JG; Department of Neuroscience, UCSD, Investigator, Howard Hughes Medical Institute, Rady Children's Institute for Genomic Medicine, San Diego, CA 92093, USA., Novarino G; Institute of Science and Technology (IST) Austria, Klosterneuburg 3400, Austria. Electronic address: gnovarino@ist.ac.at.

Publikováno v: Cell [Cell] 2016 Dec 01; Vol. 167 (6), pp. 1481-1494.e18.

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.

Autor: Sievert H; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany., Pällmann N; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany., Miller KK; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany., Hermans-Borgmeyer I; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany., Venz S; Department of Medical Biochemistry and Molecular Biology, University of Greifswald, 17475 Greifswald, Germany., Sendoel A; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland. Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland., Preukschas M; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany., Schweizer M; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany., Boettcher S; Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland., Janiesch PC; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany., Streichert T; Department of Clinical Chemistry, University Hospital of Cologne, 50924 Cologne, Germany., Walther R; Department of Medical Biochemistry and Molecular Biology, University of Greifswald, 17475 Greifswald, Germany., Hengartner MO; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland., Manz MG; Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland., Brümmendorf TH; Clinic for Internal Medicine IV, Hematology and Oncology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany., Bokemeyer C; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany., Braig M; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany., Hauber J; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany., Duncan KE; Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany., Balabanov S; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany. Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland. stefan.balabanov@usz.ch.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2014 Aug; Vol. 7 (8), pp. 963-76. Date of Electronic Publication: 2014 May 15.

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.

Autor: Kuhlbrodt K; Centre for Molecular Neurobiology (ZMNH), University of Hamburg, Falkenried 94, 20251 Hamburg, Germany., Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T

Publikováno v: Nature cell biology [Nat Cell Biol] 2011 Mar; Vol. 13 (3), pp. 273-81. Date of Electronic Publication: 2011 Feb 13.