Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Janie Parrino"'
Autor:
Alvin F. Wells, Janie Parrino, Erin K. Mangan, Anne Paccaly, Yong Lin, Christine Xu, Chunpeng Fan, Neil M. H. Graham, Hubert van Hoogstraten, Albert Torri
Publikováno v:
Rheumatology and Therapy, Vol 6, Iss 3, Pp 339-352 (2019)
Abstract Introduction This open-label study evaluated the immunogenicity, safety, and efficacy of sarilumab monotherapy in patients with active, moderate-to-severe rheumatoid arthritis (RA) and inadequate response or intolerance to prior conventional
Externí odkaz:
https://doaj.org/article/c4ff01ffaea0496db79cb29f61362bca
Publikováno v:
Emerging Infectious Diseases, Vol 13, Iss 2, Pp 191-191 (2007)
Some labile cell types whose numbers are normally controlled through programmed cell death are subject to markedly increased destruction during some severe infections. Lymphocytes, in particular, undergo massive and apparently unregulated apoptosis i
Externí odkaz:
https://doaj.org/article/eb8321d3ac6e4dae9f4f37421f7427bb
Autor:
Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Bret J Musser, John D Davis, Kenneth C Turner, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Janie Parrino, Danise Subramaniam, Alina Baum, Christos A Kyratsous, A Thomas DiCioccio, Neil Stahl, Ned Braunstein, George D Yancopoulos, David M Weinreich, Achint Chani, Adebiyi Adepoju, Aisha Mortagy, Ajla Dupljak, Alison Brown, Amy Froment, Andrea Hooper, Andrea Margiotta, Andrew Bombardier, Anita Islam, Anne Smith, Arvinder Dhillon, Audra McMillian, Aurora Breazna, Ayesha Aslam, Barabara Carpentino, Bari Kowal, Barry Siliverstein, Benjamin Horel, Bo Zhu, Bret Musser, Brian Bush, Brian Head, Brian Snow, Bryan Zhu, Camille Debray, Careta Phillips, Carmella Simiele, Carol Lee, Carolyn Nienstedt, Caryn Trbovic, Casey (Kuo-Chen) Chan, Catherine Elliott, Chad Fish, Charlie Ni, Christa Polidori, Christine Enciso, Christopher Caira, Christopher Powell, Christos A. Kyratsous, Cliff Baum, Colin McDonald, Cynthia Leigh, Cynthia Pan, Dana Wolken, Danielle Manganello, David Liu, David Stein, David M. Weinreich, Dawlat Hassan, Daya Gulabani, Deborah Fix, Deborah Leonard, Deepshree Sarda, Denise Bonhomme, Denise Kennedy, Devin Darcy, Dhanalakshmi Barron, Diana Hughes, Diana Rofail, Dipinder Kaur, Divya Ramesh, Dona Bianco, Donna Cohen, Edward Jean-Baptiste, Ehsan Bukhari, Eileen Doyle, Elizabeth Bucknam, Emily Labriola-Tomkins, Emily Nanna, Esther Huffman O'Keefe, Evelyn Gasparino, Evonne Fung, Fung-Yee To, Gary Herman, George D. Yancopoulos, Georgia Bellingham, Giane Sumner, Grainne Moggan, Grainne Power, Haixia Zeng, Hazel Mariveles, Heath Gonzalez, Helen Kang, Hibo Noor, Ian Minns, Ingeborg Heirman, Izabella Peszek, James Donohue, Jamie Rusconi, Janice Austin, Jeannie Yo, Jenna McDonnell, Jennifer D. Hamilton, Jessica Boarder, Jianguo Wei, Jingchun Yu, Joanne Malia, Joanne Tucciarone, Jodie Tyler-Gale, John D. Davis, John Strein, Jonathan Cohen, Jonathan Meyer, Jordan Ursino, Joseph Im, Joseph Tramaglini, Joseph Wolken, Kaitlyn Potter, Kaitlyn Scacalossi, Kamala Naidu, Karen Browning, Karen Rutkowski, Karen Yau, Katherine Woloshin, Kelly Lewis-Amezcua, Kenneth Turner, Kimberly Dornheim, Kit Chiu, Kosalai Mohan, Kristina McGuire, Kristy Macci, Kurt Ringleben, Kusha Mohammadi, Kyle Foster, Latora Knighton, Leah Lipsich, Lindsay Darling, Lisa Boersma, Lisa Cowen, Lisa Hersh, Lisa Jackson, Lisa Purcell, Lisa Sherpinsky, Livia Lai, Lori Faria, Lori Geissler, Louise Boppert, Lyra Fiske, Marc Dickens, Marco Mancini, Maria C. Leigh, Meagan P. O'Brien, Michael Batchelder, Michael Klinger, Michael Partridge, Michel Tarabocchia, Michelle Wong, Mivianisse Rodriguez, Moetaz Albizem, Muriel O'Byrne, Nicole Deitz, Nicole Memblatt, Nirav Shah, Nitin Kumar, Olga Herrera, Oluchi Adedoyin, Ori Yellin, Pamela Snodgrass, Patrick Floody, Paul D'Ambrosio, Paul (Xiaobang) Gao, Philippa Hearld, Qin Li, Rachel Kitchenoff, Rakiyya Ali, Ramya Iyer, Ravikanth Chava, Rinol Alaj, Rita Pedraza, Robert Hamlin, Romana Hosain, Ruchin Gorawala, Ryan White, Ryan Yu, Rylee Fogarty, S. Balachandra Dass, Sagarika Bollini, Samit Ganguly, Sandra DeCicco, Sanket Patel, Sarah Cassimaty, Selin Somersan-Karakaya, Shane McCarthy, Sharon Henkel, Shazia Ali, Shelley Geila Shapiro, Somang Kim, Soraya Nossoughi, Stephanie Bisulco, Steven Elkin, Steven Long, Sumathi Sivapalasingam, Susan Irvin, Susan Wilt, Tami Min, Tatiana Constant, Theresa Devins, Thomas DiCioccio, Thomas Norton, Travis Bernardo, Tzu-Chien Chuang, Victor (Jianguo) Wei, Vinh Nuce, Vishnu Battini, Wilson Caldwell, Xiaobang Gao, Xin Chen, Yanmei Tian, Yasmin Khan, Yuming Zhao, Yunji Kim, Bonnie Dye, Christopher B. Hurt, Dale R. Burwen, Dan H. Barouch, David Burns, Elizabeth Brown, Katharine J. Bar, Mary Marovich, Meredith Clement, Myron S. Cohen, Nirupama Sista, Ruanne V. Barnabas, Sheryl Zwerski
Publikováno v:
The Lancet Infectious Diseases. 22:1444-1454
There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete COVID-19 vaccination. We previously reported that a single subcutaneous 1200 mg dose of th
Autor:
Anita Boyapati, Pavel Kovalenko, Hubert van Hoogstraten, Anne Paccaly, Christine Xu, Janie Parrino, Tomonori Ishii, John D. Davis, A. Thomas DiCioccio
Publikováno v:
Journal of Clinical Pharmacology
We assessed pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD relationships of interleukin‐6 (IL‐6), soluble IL‐6 receptor, and C‐reactive protein (CRP) in serum, and absolute neutrophil count (ANC) in blood following single doses of su
Autor:
Roxanna Stoici, Ned Braunstein, David M. Weinreich, Cynthia Portal Celhay, Adil Fatakia, Janie Parrino, Bret J Musser, Eduardo Forleo-Neto, Christos A. Kyratsous, Leah Lipsich, John D. Davis, Adnan Mahmood, Bari Kowal, Yuhwen Soo, Gary Herman, Jennifer D. Hamilton, A. Thomas DiCioccio, Gregory P. Geba, Study Investigators, Neil Stahl, Cynthia Pan, Wendy Kampman, George D. Yancopoulos, Kenneth C. Turner, Thomas Norton, Andrea T. Hooper, Alina Baum, Yunji Kim, Will Eagan, Lilia Roque-Guerrero
SummaryBackgroundThe monoclonal antibody combination casirivimab and imdevimab (REGEN-COV®) reduced viral load, hospitalisation, or death when administered 1:1 as an intravenous (IV) dose ≥1200 mg in a phase 3 COVID-19 outpatient study. Availabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9a875a93281f66d52fbcaa787bee4b
https://doi.org/10.1101/2021.11.09.21265912
https://doi.org/10.1101/2021.11.09.21265912
Autor:
Cynthia, Portal-Celhay, Eduardo, Forleo-Neto, Will, Eagan, Bret J, Musser, John D, Davis, Kenneth C, Turner, Thomas, Norton, Andrea T, Hooper, Jennifer D, Hamilton, Cynthia, Pan, Adnan, Mahmood, Alina, Baum, Christos A, Kyratsous, Yunji, Kim, Janie, Parrino, Wendy, Kampman, Lilia, Roque-Guerrero, Roxana, Stoici, Adil, Fatakia, Yuhwen, Soo, Gregory P, Geba, Bari, Kowal, A Thomas, DiCioccio, Neil, Stahl, Leah, Lipsich, Ned, Braunstein, Gary A, Herman, George D, Yancopoulos, David M, Weinreich, Bryan, Zhu
Publikováno v:
JAMA Network Open. 5:e2225411
The monoclonal antibody combination of casirivimab and imdevimab reduced viral load, hospitalization, or death when administered as a 1200-mg or greater intravenous (IV) dose in a phase 3 COVID-19 outpatient study. Subcutaneous (SC) and/or lower IV d
Autor:
Meagan P. O'Brien, Michelle N. Gong, Suraj Saggar, Janie Parrino, Sumathi Sivapalasingam, A. Thomas DiCioccio, Vidya Menon, Romana Hosain, Judith A. Aberg, Samuel M. Brown, Ned Braunstein, Alpana Waldron, Sarilumab-COVID Study Team, Divya Ramesh, Gary Herman, Manuel A. R. Ferreira, Jack A. Kosmicki, Gerard J. Criner, D.J. Lederer, Magdalena E. Sobieszczyk, Michael C Nivens, William Park, Angeliki Giannelou, Adnan Mahmood, Lisa A. Purcell, Steven J. Sperber, Wendy Kampman, George D. Yancopoulos, Selin Somersan-Karakaya, Rafia Bhore, Julie E. Horowitz, Bret J Musser, Bari Kowal, David M. Weinreich, Aris Baras, Emily Labriola-Tompkins, Anita Boyapati, Negin Hajizadeh, Bolanle Akinlade, David Stein, Daya Gulabani
BACKGROUNDSarilumab (anti-interleukin-6 receptor-α monoclonal antibody) may attenuate the inflammatory response in Covid-19.METHODSWe performed an adaptive, phase 2/3, randomized, double-blind, placebo-controlled trial of intravenous sarilumab 200 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d11f0a3132f01ed0b8e0ae658914c48
https://doi.org/10.1101/2021.05.13.21256973
https://doi.org/10.1101/2021.05.13.21256973
Autor:
Janie Parrino, Hubert van Hoogstraten, Extend study investigators, Neil M.H. Graham, Janet van Adelsberg, Chunpeng Fan, Alberto Spindler, Tom W J Huizinga, E.K. Mangan, Désirée van der Heijde, Mark C. Genovese
Publikováno v:
Rheumatology (Oxford, England)
Objectives To examine 2-year safety, efficacy and radiographic outcomes of sarilumab in adults with RA and inadequate response to MTX (MTX-IR). Methods In the randomized, placebo-controlled MOBILITY trial, MTX-IR patients received subcutaneous sarilu
Autor:
Janie Parrino, Marina Stanislav, Hubert van Hoogstraten, Christine Xu, Alan Kivitz, Lydie Baret-Cormel, Sheldon Wang
Publikováno v:
Rheumatology and Therapy. 5:231-242
Sarilumab is a human monoclonal antibody that blocks the interleukin-6 receptor alpha (IL-6Rα). The phase 3 SARIL-RA-EASY study (EASY) assessed the robustness of an autoinjector (pen) for administering sarilumab when used by adults with active moder
Autor:
Yong Lin, Janie Parrino, Neil M.H. Graham, Juan Rondon, Nancy Liu, Anne Paccaly, Claudia Pena-Rossi, Alberto Spindler, Richard Wu, Hubert van Hoogstraten, Paul Emery
Publikováno v:
Rheumatology (Oxford, England)
Objective Safety and efficacy of mAbs blocking the IL-6 receptor have been established in RA. This is the first analysis examining safety and tolerability of sarilumab and tocilizumab administered as single or multiple doses in patients with RA withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d605e6b59c830bb6eb4ba0967b0f47f
https://eprints.whiterose.ac.uk/137385/7/key361.pdf
https://eprints.whiterose.ac.uk/137385/7/key361.pdf