Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Janie Beauregard"'
Synthesis of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3-O,4-C-Fused Galactopyranoside Scaffold
Autor:
Wael Maharsy, Mathieu Joyal, Ryan D. Simard, Pina Colarusso, Kamala D. Patel, Mona Nemer, Gianna Di Censo, Yvan Guindon, Michel Prévost, Janie Beauregard, Laura Gillard
Publikováno v:
The Journal of Organic Chemistry. 84:7372-7387
Reported herein is the synthesis of sialyl LewisX analogues bearing a trans-bicyclo[4.4.0] dioxadecane-modified 3- O,4- C-fused galactopyranoside scaffold that locks the carboxylate pharmacophore in either the axial or equatorial position. This novel
Autor:
Ryan D, Simard, Mathieu, Joyal, Laura, Gillard, Gianna, Di Censo, Wael, Maharsy, Janie, Beauregard, Pina, Colarusso, Kamala D, Patel, Michel, Prévost, Mona, Nemer, Yvan, Guindon
Publikováno v:
The Journal of organic chemistry. 84(11)
Reported herein is the synthesis of sialyl Lewis
Autor:
Wael Maharsy, Mona Nemer, Yvan Guindon, Carole-Anne Lefebvre, Starr Dostie, Laura Collins, Janie Beauregard, Marc-Olivier Labbé, Michel Prévost
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126983
A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either
Autor:
Subramanya N.M. Pandruvada, Jean Vacher, Monica Pata, Suzanne Benjannet, Nabil G. Seidah, Claude Lazure, Janie Beauregard
In humans and in mice, mutations in the Ostm1 gene cause the most severe form of osteopetrosis, a major bone disease, and neuronal degeneration, both of which are associated with early death. To gain insight into Ostm1 function, we first investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e0161d491b40fb9612b1b6d6c021b7
https://europepmc.org/articles/PMC4719428/
https://europepmc.org/articles/PMC4719428/
Publikováno v:
Journal of Biological Chemistry. 286:1508-1516
Pressure and volume overload induce hypertrophic growth of postnatal cardiomyocytes and genetic reprogramming characterized by reactivation of a subset of fetal genes. Despite intense efforts, the nuclear effectors of cardiomyocyte hypertrophy remain
Autor:
Romain O. Georges, Mona Nemer, Gregor Andelfinger, Mathieu Nadeau, Pierre Paradis, Abir Yamak, Chantal Lefebvre, Brigitte Laforest, Benoit G. Bruneau, Janie Beauregard
Publikováno v:
Proceedings of the National Academy of Sciences. 107:19356-19361
In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that
Autor:
Daniel Brasnu, Ollivier Laccourreye, Janie Beauregard, Franck Zinzindohoué, Isabelle Manière, Pierre Laurent-Puig, Hélène Blons, Philippe Beaune, Sophie Gad, David-Alexandre Trégouët
Publikováno v:
Clinical Cancer Research. 10:2594-2599
Purpose: Treatment of head and neck cancer often associates different therapeutic modalities, including surgery, radiotherapy, and chemotherapy. In an attempt to optimize therapeutics, the identification of molecular markers linked to response to che
Autor:
Hélène, Blons, Sophie, Gad, Franck, Zinzindohoué, Isabelle, Manière, Janie, Beauregard, David, Tregouet, Daniel, Brasnu, Philippe, Beaune, Ollivier, Laccourreye, Pierre, Laurent-Puig
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(8)
Treatment of head and neck cancer often associates different therapeutic modalities, including surgery, radiotherapy, and chemotherapy. In an attempt to optimize therapeutics, the identification of molecular markers linked to response to chemotherapy