Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Janid A Ali"'
Autor:
Brenda C O'Connell, Katie O'Callaghan, Bonnie Tillotson, Mark Douglas, Nafeeza Hafeez, Kip A West, Howard Stern, Janid A Ali, Paul Changelian, Christian C Fritz, Vito J Palombella, Karen McGovern, Jeffery L Kutok
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115228 (2014)
HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the m
Externí odkaz:
https://doaj.org/article/9d093119cf444dc3945b927b8fef1652
Autor:
Christian M. Martin, Jennifer Proctor, Patrick O'Hearn, Janid A. Ali, Andre Lescarbeau, Jennifer Hoyt, Jonathan P. DiNitto, Ann M. Rowley, Thomas T. Tibbitts, Catherine A. Evans, Martin R. Tremblay, Tao Liu, Vito J. Palombella, John Soglia, Johan A. Pradeilles, Somarajan J. Nair, Melissa Pink, David G. Winkler, Stanley Goldstein, Quentin Glenadel, Erin L. O’Hearn, Culver Cheung, Erin Brophy, Alfredo C. Castro, Louis Grenier
Publikováno v:
ACS Medicinal Chemistry Letters. 7:862-867
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f2e63c8dbb32a50d02e0a4d22c2564
https://doi.org/10.1021/acsmedchemlett.6b00238
https://doi.org/10.1021/acsmedchemlett.6b00238
Autor:
Alice R. Lim, Pingda Ren, Yi Liu, Jonathan P. DiNitto, Christian C. Fritz, Katti Jessen, Erin Murphy, Vito J. Palombella, Jennifer Lussier, Janid A. Ali, Brian D. Thomas, Kerry White, Lian-Sheng Li, Paul S. Changelian, Melissa Pink, Joi Dunbar, Jennifer Hoyt, Erin Brophy, Bonnie Tillotson, James R. Porter, John Macdougall, David G. Winkler, Christian Rommel, Kerrie Faia, Christian M. Martin, Jennifer L. Proctor, Jeffery L. Kutok
Publikováno v:
Chemistry & Biology. 20:1364-1374
SummaryPhosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5813545be8573cae8ff4e65a9ba3e19c
https://doi.org/10.1016/j.chembiol.2013.09.017
https://doi.org/10.1016/j.chembiol.2013.09.017
Autor:
Patrick O'Hearn, Janid A. Ali, Kelly Slocum, Jitendra D. Belani, Sherri Smith, Tao Liu, Adilah Bahadoor, Andre Lescarbeau, Somarajan J. Nair, Christian C. Fritz, Karen McGovern, Kip A. West, Joseph Helble, Bonnie Tillotson, Martin R. Tremblay, Wylie Andrew A, Vito J. Palombella, Alfredo C. Castro, Stéphane Peluso, James M. Conley, Mark Douglas
Publikováno v:
Journal of Medicinal Chemistry. 55:8859-8878
Misregulation of protein translation plays a critical role in human cancer pathogenesis at many levels. Silvestrol, a cyclopenta[b]benzofuran natural product, blocks translation at the initiation step by interfering with assembly of the eIF4F transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8e686d0a86b9c6d0b9d6e0f79d708d
https://doi.org/10.1021/jm3011542
https://doi.org/10.1021/jm3011542
Autor:
John Coco, Christian C. Fritz, Kip A. West, Emmanuel Normant, Vito J. Palombella, John Macdougall, Nigel Whitebread, Bonnie Tillotson, Jie Ge, Kelly Slocum, Brian Thomas, Janid A. Ali, Julian Adams
Publikováno v:
The Journal of Biological Chemistry
Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects on client protein degradation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b9fcc7ade0f8d08aa77671f1cc9cf2
https://doi.org/10.1074/jbc.m110.141580
https://doi.org/10.1074/jbc.m110.141580
Autor:
Roger H. Pak, Louis Grenier, Julian Adams, Jeffrey K. Tong, James D. Wright, Janid A. Ali, Courtney Penders, Emmanuel Normant, Jens R. Sydor, Jon S. Patterson, Melissa Pink, Jie Ge, Jebecka Hudak, Marlene Dembski, Yilong Zhang, Jim Sang, Christine S. Pien, Caroline N. Woodward, James R. Porter, Margaret Read, John A. Barrett, David Grayzel, Vito J. Palombella
Publikováno v:
Proceedings of the National Academy of Sciences. 103:17408-17413
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f11c8483df52f90a7ab65229a46a8d6
https://doi.org/10.1073/pnas.0608372103
https://doi.org/10.1073/pnas.0608372103
Autor:
Andrew F. Taylor, Aaron L. Lucius, Janid A. Ali, Alessandro Vindigni, Timothy M. Lohman, Gerald R. Smith, Razmic Gregorian
Publikováno v:
Journal of Molecular Biology. 324:409-428
The mechanism by which Escherichia coli RecBCD DNA helicase unwinds duplex DNA was examined in vitro using pre-steady-state chemical quenched-flow kinetic methods. Single turnover DNA unwinding experiments were performed by addition of ATP to RecBCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1711d4989b347900c137a53601e7d681
https://doi.org/10.1016/s0022-2836(02)01067-7
https://doi.org/10.1016/s0022-2836(02)01067-7
Autor:
Bonnie Tillotson, Vito J. Palombella, Jeffery L. Kutok, Christian Fritz, Brenda O'Connell, Kip A. West, Paul S. Changelian, Howard M. Stern, Janid A. Ali, Nafeeza Hafeez, Mark W. Douglas, Karen McGovern, Katie O'Callaghan
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115228 (2014)
PLoS ONE
PLoS ONE
HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e73d8896c8d30d0ce6596b24d942bcc
http://europepmc.org/articles/PMC4277299?pdf=render
http://europepmc.org/articles/PMC4277299?pdf=render
Publikováno v:
Journal of Molecular Biology. 293:815-834
Pre-steady-state chemical quenched-flow techniques were used to study DNA unwinding catalyzed by Escherichia coli UvrD helicase (helicase II), a member of the SF1 helicase superfamily. Single turnover experiments, with respect to unwinding of a DNA o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2dccfc1e12c5b5e37aa476cfdc61034
https://doi.org/10.1006/jmbi.1999.3185
https://doi.org/10.1006/jmbi.1999.3185
Autor:
Janid A. Ali, Timothy M. Lohman
Publikováno v:
Science. 275:377-380
The kinetic mechanism by which the DNA repair helicase UvrD of Escherichia coli unwinds duplex DNA was examined with the use of a series of oligodeoxynucleotides with duplex regions ranging from 10 to 40 base pairs. Single-turnover unwinding experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8e556aa2686eeb4ddbb382f1b52297
https://doi.org/10.1126/science.275.5298.377
https://doi.org/10.1126/science.275.5298.377