Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Janice S. Gilsdorf"'
Autor:
Bharani Thangavelu, Bernard S. Wilfred, David Johnson, Janice S. Gilsdorf, Deborah A. Shear, Angela M. Boutté
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Severe traumatic brain injury (TBI) is a risk factor for neurodegenerative diseases. Yet, the molecular events involving dysregulated miRNAs that may be associated with protein degradation in the brain remains elusive. Quantitation of more than 800 m
Externí odkaz:
https://doaj.org/article/ef49138815844e46bb9a8f9cc728a63f
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105657- (2020)
This article provides information regarding the effect of four common high abundant protein (albumin and immunoglobulins (Ig)) depletion strategies upon serum proteomics datasets derived from normal, non-diseased rat or human serum. After tryptic dig
Externí odkaz:
https://doaj.org/article/dd59d413b67541ff80543f1177157469
Autor:
Jignesh D. Pandya, Lai Yee Leung, Xiaofang Yang, William J. Flerlage, Janice S. Gilsdorf, Ying Deng-Bryant, Deborah A. Shear
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Mitochondria constitute a central role in brain energy metabolism, and play a pivotal role in the development of secondary pathophysiology and subsequent neuronal cell death following traumatic brain injury (TBI). Under normal circumstances, the brai
Externí odkaz:
https://doaj.org/article/0326c523cc144c7b8948aeff20bd7916
Autor:
Sindhu K. Madathil, Bernard S. Wilfred, Sarah E. Urankar, Weihong Yang, Lai Yee Leung, Janice S. Gilsdorf, Deborah A. Shear
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Microglial activation is a pathological hallmark of traumatic brain injury (TBI). Following brain injury, activated microglia/macrophages adopt different phenotypes, generally categorized as M-1, or classically activated, and M-2, or alternatively ac
Externí odkaz:
https://doaj.org/article/4b51e09e42894aa4835307f63f363c5c
Autor:
Patrick M. Kochanek, C. Edward Dixon, Stefania Mondello, Kevin K. K. Wang, Audrey Lafrenaye, Helen M. Bramlett, W. Dalton Dietrich, Ronald L. Hayes, Deborah A. Shear, Janice S. Gilsdorf, Michael Catania, Samuel M. Poloyac, Philip E. Empey, Travis C. Jackson, John T. Povlishock
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Current approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinical and clini
Externí odkaz:
https://doaj.org/article/c981f870a73444de9b3b3084fec2d91d
Autor:
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Ying Cao, William J. Flerlage, Linda Huynh, Brittany Kociuba, Nishant P. Visavadiya, Firas Kobeissy, Kevin Wang, Janice S. Gilsdorf, Anke H. Scultetus, Deborah A. Shear
Publikováno v:
Free Radical Biology and Medicine. 198:44-58
Autor:
Jeremy Henchir, Shaun W. Carlson, Benjamin E Zusman, Zachary S. Bailey, Vincent Vagni, Ruchira M. Jha, Keri Janesko-Feldman, Janice S. Gilsdorf, Patrick M. Kochanek, Deborah A. Shear, C. Edward Dixon
Publikováno v:
J Neurotrauma
Civilian traumatic brain injury (TBI) guidelines recommend resuscitation of patients with hypotensive TBI with crystalloids. Increasing evidence, however, suggests that whole blood (WB) resuscitation may improve physiological and survival outcomes at
Autor:
Patrick M. Kochanek, David O. Okonkwo, Vincent Vagni, Ruchira M. Jha, Keri Janesko-Feldman, Zachary S. Bailey, Lori Shutter, Benjamin E Zusman, Ava M. Puccio, Deborah A. Shear, Lai Yee Leung, Janice S. Gilsdorf
Publikováno v:
Neurocrit Care
BACKGROUND: Despite increasing use in hemorrhagic shock (HS), whole blood (WB) resuscitation for polytrauma with traumatic brain injury (TBI) is largely unexplored. Current TBI guidelines recommend crystalloid for prehospital resuscitation. Although
Autor:
Janice S. Gilsdorf, Zhihui Yang, Bharani Thangavelu, Claudia S. Robertson, Deborah A. Shear, Kevin K.W. Wang, George Anis Sarkis, Vivian Hook, Brittany N Abbatiello, Gregory Hook, J. Steven Jacobsen, Angela M. Boutté
Publikováno v:
J Neurotrauma
Cathepsin B (CatB), a lysosomal cysteine protease, is important to brain function and may have dual utility as a peripheral biomarker of moderate-severe traumatic brain injury (TBI). The present study determined levels of pro- and mature (mat) CatB p
Autor:
Hye Hwang, Sarah E. Urankar, Lai Yee Leung, Bernard S Wilfred, Janice S. Gilsdorf, Sindhu K. Madathil, Deborah A. Shear, Katherine Cardiff, Xiaofang Yang
Publikováno v:
Journal of Neurotrauma
Polytrauma, with combined traumatic brain injury (TBI) and systemic damage are common among military and civilians. However, the pathophysiology of peripheral organs following polytrauma is poorly understood. Using a rat model of TBI combined with hy