Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Janice S. Blum"'
Autor:
Matthew J. Justice, Irina Bronova, Kelly S. Schweitzer, Christophe Poirier, Janice S. Blum, Evgeny V. Berdyshev, Irina Petrache
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 596-606 (2018)
Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy. We set out to investigate the role of the baseline ASM activity in maint
Externí odkaz:
https://doaj.org/article/da0ad77a0abe46929b832b8710148ec7
Autor:
Gail J Ocaña, Emily K Sims, Renecia A Watkins, Susanne Ragg, Kieren J Mather, Richard A Oram, Raghavendra G Mirmira, Linda A DiMeglio, Janice S Blum, Carmella Evans-Molina
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208456 (2019)
Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We hypothesized that serum Hsp90 may have utility as a biomarker of type 1 diabetes risk and exhibit ele
Externí odkaz:
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Autophagy plays critical but diverse roles in cellular quality control and homeostasis potentially checking tumor development by removing mutated or damaged macromolecules, while conversely fostering tumor survival by supplying essential nutrients du
Externí odkaz:
https://doaj.org/article/884441775bd94b2c9b45e56f3c054efa
Autor:
Gail J Gardiner, Sarah N Deffit, Shawna eMcLetchie, Liliana ePérez, Crystal C Walline, Janice S Blum
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2.-). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen s
Externí odkaz:
https://doaj.org/article/00925d87b48b4dbbad61dd66c53af474
Autor:
Crystal C Walline, Sarita Sehra, Amanda J Fisher, Lynette M Guindon, Ian M Kratzke, Jessica B Montgomery, Kelsey P Lipking, Nicole L Glosson, Heather L Benson, George E Sandusky, David S Wilkes, Randy R Brutkiewicz, Mark H Kaplan, Janice S Blum
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62222 (2013)
Pulmonary viral infections can exacerbate or trigger the development of allergic airway diseases via multiple mechanisms depending upon the infectious agent. Respiratory vaccinia virus transmission is well established, yet the effects of allergic air
Externí odkaz:
https://doaj.org/article/aeae8b837aed456188f404888bdb4089
Autor:
Peter Arvan, Adam C. Swensen, C. Max Schmidt, Leena Haataja, Henry T. Bahnson, Raghavendra G. Mirmira, Robert V. Considine, Carmella Evans-Molina, Margaret A. Morris, Cate Speake, Lian Yi, Emily K. Sims, Wei-Jun Qian, Michele T. Yip-Schneider, Jerry L. Nadler, Teresa L. Mastracci, Linda A. DiMeglio, Julius O. Nyalwidhe, Santica Marcovina, Janice S. Blum, Asa K. Davis, Carla J. Greenbaum
Publikováno v:
Diabetes Care. 42:258-264
OBJECTIVE Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132d14ba99b8edd2565ee96abf4f4b9e
https://doi.org/10.2337/dc17-2625
https://doi.org/10.2337/dc17-2625
Publikováno v:
Journal of Investigative Medicine. 66:1-4
Excessive drinking can lead to the development of immune dysfunction. Our aim is to investigate the effect of alcohol on immune activation from circulating peripheral blood monocytes in excessive drinkers (EDs). Twenty-two EDs and healthy controls we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd54ebdfd3ea97bba896dbebbc43d22a
https://doi.org/10.1136/jim-2017-000706
https://doi.org/10.1136/jim-2017-000706
Publikováno v:
Blood Cells Mol Dis
Gamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3065c959eb2f84e8510594eff4f2f865
https://doi.org/10.1016/j.bcmd.2021.102574
https://doi.org/10.1016/j.bcmd.2021.102574
Autor:
Emily K. Sims, Renecia A. Watkins, Raghavendra G. Mirmira, Gail J. Ocaña, Carmella Evans-Molina, Richard A. Oram, Linda A. DiMeglio, Janice S. Blum, Kieren J. Mather, Susanne Ragg
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208456 (2019)
PLoS ONE
PLoS ONE
Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We hypothesized that serum Hsp90 may have utility as a biomarker of type 1 diabetes risk and exhibit ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8db661903055d799710694891601748
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
Autor:
Renecia A. Watkins, Raghavendra G. Mirmira, Zunaira Chaudhry, Carmella Evans-Molina, Linda A. DiMeglio, Emily K. Sims, Fangqian Ouyang, Jay M. Sosenko, Susan M. Perkins, Farooq Syed, Janice S. Blum
Publikováno v:
Diabetes Care
OBJECTIVE We tested whether an elevation in the serum proinsulin–to–C-peptide ratio (PI:C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with progression to type 1 diabetes. RESEARCH DESIGN AND METHODS Fasting tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c349c86b3f2d552f08389e2f26a0dd7b
http://europepmc.org/articles/PMC5001142
http://europepmc.org/articles/PMC5001142