Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Janice Ryan Young"'
Autor:
Carla Musso, Elaine Cochran, Phillip Gorden, Janice Ryan Young, Edward D. Javor, Alex M. DePaoli
Publikováno v:
Diabetes. 54:1994-2002
Ectopic fat accumulation has been implicated as a contributing factor in the abnormal metabolic state of obesity. One human model of ectopic fat deposition is generalized lipodystrophy. Generalized lipodystrophy is a rare disorder characterized by a
Autor:
Piers R. Blackett, Elaine Cochran, Alex M. DePaoli, Elif A. Oral, Phillip Gorden, Stephen O'Rahilly, David B. Savage, Martin A. Turman, James E. Balow, Janice Ryan Young, Edward D. Javor, Stephanie Ann Moran
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:3199-3207
Generalized lipodystrophy is characterized by adipose tissue absence, hypoleptinemia, hypertriglyceridemia, insulin resistance, diabetes, hepatomegaly, and nonalcoholic steatohepatitis. In the course of recruiting patients for treatment with recombin
Autor:
Janice Ryan Young, Nancy G. Sebring, Elaine Cochran, Stephanie Ann Moran, Elif A. Oral, Alex M. DePaoli, Nicole Patten, James C. Reynolds, Ahalya Premkumar, Monica C. Skarulis, Phillip Gorden
Publikováno v:
Metabolism. 53:513-519
Leptin, an adipocyte hormone, when replaced in patients with lipodystrophy, improves insulin resistance, hyperglycemia, dyslipidemia, and hepatic steatosis. Changes in body composition accompany this metabolic improvement. We studied 14 patients (3 m
Autor:
Gulbu Uzel, Phillip Gorden, Edward D. Javor, Elif A. Oral, Li Ding, Janice Ryan Young, Elaine Cochran, Steven M. Holland, Alex M. DePaoli
Publikováno v:
The Journal of clinical endocrinology and metabolism. 91(2)
We conducted this study to understand the role of leptin therapy in immunomodulation.Our objective was to study lymphocyte subpopulations and in vitro peripheral blood mononuclear cell (PBMC) activation during a study evaluating the effects of leptin
Autor:
Elaine Cochran, Phillip Gorden, Nancy G. Sebring, Janice Ryan Young, Elif A. Oral, Alex M. DePaoli
Publikováno v:
The Journal of clinical endocrinology and metabolism. 89(4)
Recombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the treatment of severe insulin resistance associated with lipodystrophy syndromes and low leptin levels. We treated two siblings with Rabson-Mendenhall syndrome (
Autor:
Bernice Marcus-Samuels, Sheryl Leventhal, M. Joycelyn Elders, Simeon I. Taylor, Janice Ryan-Young
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 62:1130-1135
A patient with extreme insulin resistance (leprechaun/Ark-1) had an 80-90% decrease in the number of insulin receptors on her circulating monocytes. In contrast, while a normal number of insulin receptors was expressed on the surface of Epstein-Barr