Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Janice Rowe"'
Publikováno v:
Cancer Research. 72:165-175
The cyclin-dependent kinase (CDK) inhibitors, p18INK4c and p16INK4a, both have the credentials of tumor suppressors in human cancers and mouse models. For p16INK4a, the underlying rationale is its role in senescence, but the selective force for inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b306642c5a92cfa270c6276d903f64
https://doi.org/10.1158/0008-5472.can-11-2552
https://doi.org/10.1158/0008-5472.can-11-2552
Publikováno v:
Journal of Bone and Mineral Research. 11:512-520
Alkaline phosphatase (ALP) plays an important role in bone mineralization; high levels in differentiated osteoblasts allows their identification easily in vitro. It is generally assumed that the activity of ALP in osteosarcoma-derived cell lines comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a992df9b37c1b1949fe54a71d1987b
https://doi.org/10.1002/jbmr.5650110412
https://doi.org/10.1002/jbmr.5650110412
Autor:
Sharon Brookes, Elaine Sanij, Sladjana Gagrica, Fiona Gregory, Eiji Hara, Gordon Peters, Janice Rowe
Publikováno v:
Cell Cycle
Cellular senescence, the stable cell cycle arrest elicited by various forms of stress, is an important facet of tumor suppression. Although much is known about the key players in the implementation of senescence, including the pRb and p53 axes and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2e8a03ff8a12ef5df260127def8ba2
https://pubmed.ncbi.nlm.nih.gov/25790252
https://pubmed.ncbi.nlm.nih.gov/25790252
Publikováno v:
Oncogene. 23:6186-6192
Fusion proteins containing the amino-terminal domain of human p14(ARF) linked to green fluorescent protein are able to bind MDM2 and stabilize p53 without localization in the nucleolus. However, these fusion proteins are inherently unstable, with hal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6f323386bcf6e2c108fcfdfb2ef680
https://doi.org/10.1038/sj.onc.1207854
https://doi.org/10.1038/sj.onc.1207854
Publikováno v:
Cell Cycle. 3:609-613
Human cells, including fibroblast strains that have been immortalized by telomerase, are much more resistant to transformation than rodent cells. Most of the experimental evidence suggests that transformation of human fibroblasts requires inactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6bee956cab24c832c1912c3cfe21258
https://doi.org/10.4161/cc.3.5.837
https://doi.org/10.4161/cc.3.5.837
Autor:
Thomas J. G. Huot, Veronique Bataille, Patricia Purkis, Eiji Hara, Gordon Peters, Mike Fried, Janice Rowe, Sharon Brookes, Julia Newton-Bishop, Sarah Drayton, Mark Harland, Chandra Gooptu
Publikováno v:
Molecular and Cellular Biology. 22:8135-8143
The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are distinct proteins encoded by transcripts in which a shared exon is decoded in alternative reading fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9bd34cd14499ed1e83beff35653226
https://doi.org/10.1128/mcb.22.23.8135-8143.2002
https://doi.org/10.1128/mcb.22.23.8135-8143.2002
Autor:
Susana Llanos, Nelleke A. Gruis, Karen H. Vousden, Paula A. Clark, Stewart Bates, Gordon Peters, Margarida Ruas, Marion C. James, Janice Rowe, Radost Vatcheva, Sharon Brookes, Martine Lomax, Nico P.M. Smit, David A.D. Parry, Wilma Bergman
Publikováno v:
The EMBO Journal. 21:2936-2945
The CDKN2A tumour suppressor locus encodes two distinct proteins, p16(INK4a) and p14(ARF), both of which have been implicated in replicative senescence, the state of permanent growth arrest provoked in somatic cells by aberrant proliferative signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf85f4a2b400511fc45a3b48b416a754
https://doi.org/10.1093/emboj/cdf289
https://doi.org/10.1093/emboj/cdf289
Publikováno v:
Nature Cell Biology. 3:445-452
The alternative product of the human INK4a/ARF locus, p14ARF, has the potential to act as a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models propose that ARF function depends on its ability to sequester MDM2 in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd8381894696e82b947d8c014cc76b6
https://doi.org/10.1038/35074506
https://doi.org/10.1038/35074506
Autor:
Sevda Hassan, Akira Matsuno, J. Paul Chapple, Katsuhiko Yoshimoto, John A.H. Wass, Mônica R. Gadelha, Antônio Ribeiro-Oliveira, Gordon Peters, Maria Gueorguiev, Lawrence A. Frohman, Richard N. Clayton, Scott Akker, Susana Igreja, Jessica A. Wray, Daniel M. Berney, Mâdâlina Musat, Harvinder Chahal, Márta Korbonits, Kuniki Eguchi, Marie Stolbrink, John P Monson, Chrysanthia A. Leontiou, Helen C. Christian, Jacqueline van der Spuy, Suzanne Jordan, Richard Quinton, Graeme B. Bolger, Takeo Iwata, Ashley B. Grossman, David Bishop-Bailey, Francesca Lolli, Vera Popovic, Daniel Flanagan, Julian R. E. Davis, Janice Rowe
CONTEXT: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone is involved in tumorigenesis. OBJECTIVE: AI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4081b921550f62463dea970a125515
http://hdl.handle.net/11573/760799
http://hdl.handle.net/11573/760799
