Výsledky vyhledávání - "Janice R. Connor"

Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues

Autor: Janice R. Connor, R.A. Dodds, Maxine Gowen, Fred H. Drake

Publikováno v: Arthritis & Rheumatism. 42:1588-1593

Objective To investigate the expression of cathepsin K messenger RNA (mRNA) in the giant cells found in human osteoarthritic (OA) synovium and associated reparative connective tissues, and to compare this with mRNA expression of cathepsins B, L, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a31e157242f3c99e6e3a81047b5fe48
https://doi.org/10.1002/1529-0131(199908)42:8<1588::aid-anr4>3.0.co

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Cynomolgus Monkey (Macaca fascicularis) Cathepsin K: Cloning, Expression, Purification, and Activation

Autor: Bernard Y. Amegadzie, Christopher Jones, Kannan Ramachandran, Michael S. McQueney, Fred H. Drake, Charles R. Hanning, Janice R. Connor, John A. Feild, Kimberly A. Brun

Publikováno v: Protein Expression and Purification. 14:387-394

Methodology for the production of recombinant active cynomolgus monkey (Macaca fascicularis) cathepsin K (EC 3.4.22.38) was elucidated. The cDNA encoding the cathepsin K was cloned from female M. cynomolgus monkey mRNA. The deduced amino acid sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12037d5962dde077a5353cc0594ab801
https://doi.org/10.1006/prep.1998.0965

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Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse Development

Autor: F. Drake, R.A. Dodds, John A. Feild, Maxine Gowen, Janice R. Connor

Publikováno v: Journal of Bone and Mineral Research. 13:673-682

We recently identified a novel cysteine protease, cathepsin K, by random sequencing of an osteoclast cDNA library, and in situ hybridization studies in adult human tissues demonstrated high and specific expression in osteoclasts. To determine whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a74b8fbc124fb3cc31bced56654ea50
https://doi.org/10.1359/jbmr.1998.13.4.673

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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Autor: Thomas Joseph Carr, Mary J. Bossard, Alison M. Badger, Thaddeus A. Tomaszek, Fred H. Drake, Mark Alan Levy, Lawrence Szewczuk, Scott K. Thompson, Ian E. James, Bartholomew J. Votta, Daniel F. Veber, Maxine Gowen, Janice R. Connor, R.A. Dodds, Bradbeer Jeremy N

Publikováno v: Journal of Bone and Mineral Research. 12:1396-1406

We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in osteoclasts and is the predominant cysteine protease in these cells. Based upon its abundant cell typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4955992b9c29efcb62ab66cb1b50dee7
https://doi.org/10.1359/jbmr.1997.12.9.1396

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The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein

Autor: Ian Brooks, Patrick McDevitt, K D Kopple, Don E. Griswold, John A. Feild, Janice R. Connor, Preston Hensley, John J. Trill, Dean E. McNulty, N V Kumar

Publikováno v: Journal of Biological Chemistry. 269:23949-23958

The gene coding for a soluble form of human E-selectin (sE-selectin) has been expressed in Chinese hamster ovary (CHO) cells. Cells seeded into a hollow fiber reactor secreted protein at a level of 160 mg/liter. The protein was purified to > 95% pure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96248aa76b6dba315b7153a3662b3ec7
https://doi.org/10.1016/s0021-9258(19)51030-4

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Interleukin-1 release by rat synovial cells is dependent on sequential treatment with γ-interferon and lipopolysaccharide

Autor: John Breton, Janice R. Connor, Paul C. Meunier, William J. Johnson, Tonie Newman‐Tarr, Barbara J. Dalton

Publikováno v: Arthritis & Rheumatism. 33:261-267

To determine the potential regulatory mechanisms involved in synovial cell interleukin-1 (IL-1) release, the ability of gamma-interferon (gamma-IFN) to influence IL-1 release was assessed. Rat synovial cells cultured in the presence of a variety of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146646a32de3b5600ba3f2dc8482f6bc
https://doi.org/10.1002/art.1780330216

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The application of immunocytochemistry and in situ hybridization to cryostat sections of undecalcified bone

Autor: Ian E. James, Janice R. Connor, R.A. Dodds

Publikováno v: Methods in Bone Biology ISBN: 9780412757709

This chapter presents the in situ techniques for determining the temporal and spatial expression patterns of both mRNA (in situ hybridization) and protein (immuno-cytochemistry) in individual cells within sections of bone.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c5e179ddc98e0bd169f506e894b21f1
https://doi.org/10.1007/978-0-585-38227-2_8

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Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

Autor: Fred H. Drake, Michael W. Lark, Stephen Holmes, David J. Rieman, Ian E. James, Maxine Gowen, Reina Ahern, Shing Mei Hwang, Daniel F. Veber, Scott D. Thompson, R.A. Dodds, Janice R. Connor

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16(3)

Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast-mediated bone resorption. We have developed a sensitive cytochemical assay to localize and quantify osteoclast cathepsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0dbacdb03968160f5c242a4bddc46
https://pubmed.ncbi.nlm.nih.gov/11277265

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