Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Janice Mary Knowlden"'
Background: Approximately 75% of all breast cancer diagnoses are oestrogen receptor a (ERa) positive. In such ERa positive subtypes, anti-hormones such as fulvestrant and tamoxifen are a mainstay therapy. However, the efficacy of these agents is seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c2f647936cf7b52f07a708d9d675e2
https://orca.cardiff.ac.uk/id/eprint/141215/1/thebsdj_5_1_2021_bsdj.184.pdf
https://orca.cardiff.ac.uk/id/eprint/141215/1/thebsdj_5_1_2021_bsdj.184.pdf
Autor:
Julia Margaret Wendy Gee, Janice Mary Knowlden, Iain Robert Hutcheson, Robert Ian Nicholson, Denise Barrow, S. Hiscox, John F.R. Robertson, Ian O. Ellis
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-1 (2018)
Breast Cancer Research, Vol 20, Iss 1, Pp 1-1 (2018)
Resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies is an emerging clinical problem. The efficacy of anti-EGFR therapies can be influenced by the presence of heregulins (HRGs), which can bind erbB3/4 receptors and can activate a
Autor:
Denise Barrow, Robert Ian Nicholson, Janice Mary Knowlden, Iain Robert Hutcheson, Julia Margaret Wendy Gee
Publikováno v:
Endocrinology. 146:4609-4618
There is considerable evidence that the epidermal growth factor receptor (EGFR) and IGF-I receptor (IGF-IR) cross-talk in breast cancer cells. In the present study, we have examined whether EGFR/IGF-IR cross-talk exists in EGFR-positive tamoxifen-res
Autor:
Denise Barrow, Stephen Edward Hiscox, Janice Mary Knowlden, Nicola Jane Jordan, Julia Margaret Wendy Gee, Robert Ian Nicholson, Maureen Elaine Harper, Iain Robert Hutcheson, Helen E. Jones
Publikováno v:
Clinical Cancer Research. 10:346s-354s
An increasing body of evidence demonstrates that growth factor networks are highly interactive with estrogen receptor signaling in the control of breast cancer growth. As such, tumor responses to antiestrogens are likely to be a composite of the estr
Autor:
Julia Margaret Wendy Gee, Janice Mary Knowlden, Bryan Paul Morgan, John F.R. Robertson, Robert Ian Nicholson, Maureen Elaine Harper, N. K. Rushmere
Publikováno v:
International Journal of Cancer. 108:930-936
We have examined the relative mRNA expression of the complement (C) regulatory proteins CD59, CD55 and CD46 in RNA isolated from 50 primary breast cancer specimens using a semiquantitative RT-PCR approach. Having normalized the mRNA expression levels
Autor:
Denise Barrow, Robert Ian Nicholson, A. E. Wakeling, Julia Margaret Wendy Gee, Nicola Jane Jordan, Maureen Elaine Harper, Janice Mary Knowlden, Richard Andrew McClelland, Tracie-Ann Madden, Iain Robert Hutcheson
Publikováno v:
Endocrinology. 144:5105-5117
Although many estrogen receptor-positive breast cancers initially respond to antihormones, responses are commonly incomplete with resistance ultimately emerging. Delineation of signaling mechanisms underlying these phenomena would allow development o
Autor:
Robert Ian Nicholson, Janice Mary Knowlden, Iain Robert Hutcheson, A. E. Wakeling, Tracie-Ann Madden, Julia Margaret Wendy Gee, Denise Barrow
Publikováno v:
Breast Cancer Research and Treatment. 81:81-93
Oestrogen receptor (ER) levels are usually maintained on acquisition of tamoxifen resistance in the clinic, however, tumour re-growth is associated with increased expression of epidermal growth factor receptor (EGFR) and activation of the mitogen act
Autor:
Iain Robert Hutcheson, Robert Ian Nicholson, Helen E. Jones, Janice Mary Knowlden, A. E. Wakeling, Tracie-Ann Madden, Denise Barrow, Julia Margaret Wendy Gee, Maureen Elaine Harper
Publikováno v:
Endocrinology. 144:1032-1044
The development of acquired resistance to antihormonal agents in breast cancer is a major therapeutic problem. We have developed a tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line to investigate the mechanisms behind this condition. Both epi
Autor:
Denise Barrow, A. E. Wakeling, Helen E. Jones, Janice Mary Knowlden, Maureen Elaine Harper, Robert Ian Nicholson, Julia Margaret Wendy Gee, Iain Robert Hutcheson, Richard Andrew McClelland
Publikováno v:
Endocrine-related cancer. :175-182
There is an increasing body of evidence demonstrating that growth factor networks are highly interactive with oestrogen receptor (ER) signalling in the control of breast cancer growth. As such, tumour responses to anti- hormones are likely to be a co
Autor:
Janice Mary Knowlden, Robert Ian Nicholson, Julia Margaret Wendy Gee, Ian O. Ellis, John F.R. Robertson
Publikováno v:
International Journal of Cancer. 89:209-212
We have examined the relative levels of oestrogen receptor beta (ERβ) mRNA in 94 breast cancer specimens using a semi-quantitative RT-PCR procedure. We correlated its expression with ERα and various clinical, pathological and biochemical features o