Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Janice M Spence"'
Autor:
W. Richard Burack, Janice M. Spence, John P. Spence, Stephen A. Spence, Philip J. Rock, Gautam N. Shenoy, Leonard D. Shultz, Richard B. Bankert, Steven H. Bernstein
Publikováno v:
Blood Advances, Vol 1, Iss 16, Pp 1263-1273 (2017)
Abstract: To discern features of non-Hodgkin lymphomas (NHL) that are autonomous from those that are shaped by the tumor environment (TE), we used patient-derived xenografts (PDX) to probe the effects on neoplastic cells of manipulating the TE. Prope
Externí odkaz:
https://doaj.org/article/17dc5aacbe05446cb7239a3cd9973875
Autor:
Carol Fries Simpson, Janice M Spence, Cameron Baker, Aayush Poudel, John P Spence, Philip J Rock, Hongyue Wang, Diana G Adlowitz, Helene R McMurray, Andrew McDavid, Richard Burack
Publikováno v:
Blood. 140:6363-6364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521132c44ef638d7d4d17dd5d698d842
https://doi.org/10.1182/blood-2022-166848
https://doi.org/10.1182/blood-2022-166848
Autor:
W. Richard Burack, Diana G Adlowitz, Philip J Rock, Carol Fries, John P. Spence, Janice M. Spence
Publikováno v:
Pediatr Blood Cancer
Acute lymphoblastic leukemia (ALL) is often composed of numerous subclones. Here we test whether the clonal composition of the blood is representative of the bone marrow at leukemia onset. Using ultra-deep IGH sequencing, we detected 28 clones across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9352b5a4bf6f446f7fa39aa8e23dc673
https://europepmc.org/articles/PMC7258142/
https://europepmc.org/articles/PMC7258142/
Autor:
Stephen A. Spence, Steven H. Bernstein, Richard B. Bankert, Leonard D. Shultz, W. Richard Burack, Janice M. Spence, Gautam N Shenoy, Philip J Rock, John P. Spence
Publikováno v:
Blood Advances. 1:1263-1273
To discern features of non-Hodgkin lymphomas (NHL) that are autonomous from those that are shaped by the tumor environment (TE), we used patient-derived xenografts (PDX) to probe the effects on neoplastic cells of manipulating the TE. Properties of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576467c8ae69e7097cd44903a3e04117
https://doi.org/10.1182/bloodadvances.2017005892
https://doi.org/10.1182/bloodadvances.2017005892
Publikováno v:
The Journal of Immunology. 193:4888-4894
Cancers are characterized by genomic instability, and the resulting intraclonal diversity is a prerequisite for tumor evolution. Therefore, metrics of tumor heterogeneity may prove to be clinically meaningful. Intraclonal heterogeneity in follicular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f91a142588c176063eeee2a64505fc8d
https://doi.org/10.4049/jimmunol.1401699
https://doi.org/10.4049/jimmunol.1401699
Autor:
Janice M. Spence, Michael LeBlanc, John P. Leonard, Catherine M. Spier, Lisa M. Rimsza, Sonali M. Smith, Mark S. Kaminski, Diana G Adlowitz, Richard Burack, Hongli Li, Rita M. Braziel, Richard I. Fisher, Jonathan W. Friedberg
Publikováno v:
Blood. 134:2771-2771
Background: Activation induced cytidine deaminase (AICDA or AID) causes somatic hypermutation (SHM) of the immunoglobulin heavy chain variable genes (IGHV). It has been widely hypothesized that aberrant targeting of AICDA creates additional driver mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12de1fa705f6adb6c58996fafaaf015c
https://doi.org/10.1182/blood-2019-121632
https://doi.org/10.1182/blood-2019-121632
Autor:
Philip J Rock, Carol Fries, Diana G Adlowitz, John P. Spence, Richard Burack, Janice M. Spence
Publikováno v:
Blood. 134:3955-3955
Background: Recombination-activating gene (RAG) mediates recombination of the immunoglobulin heavy chain variable gene (IGHV) in immature B lymphocytes. Aberrant targeting of RAG to non-IGH sites in B cell acute lymphoblastic leukemia (B-ALL) contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7f72dcf87c9cb755fb002de90f2050
https://doi.org/10.1182/blood-2019-128660
https://doi.org/10.1182/blood-2019-128660
Publikováno v:
The Journal of Molecular Diagnostics. 13:252-262
We demonstrate an approach that allowed rapid development of a robust assay for the detection of chromosomal translocations. The method includes highly multiplexed PCR with analysis of the PCR products performed by array detection. As proof of princi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d4d84dba255fff644bc4108063734b4
https://doi.org/10.1016/j.jmoldx.2010.11.019
https://doi.org/10.1016/j.jmoldx.2010.11.019
Autor:
Catherine M. Spier, Michael LeBlanc, Rita M. Braziel, Diana G Adlowitz, Hongli Li, Lisa M. Rimsza, Janice M. Spence, Richard I. Fisher, Jonathan W. Friedberg, John P. Leonard, Mark S. Kaminski, Richard Burack, Sonali M. Smith
Publikováno v:
Blood. 132:919-919
Background: TP53 is reported to be mutated in about 20% of transformed and/or relapsed follicular lymphoma (FL) specimens but in fewer than 5% of pre-treatment FL specimens. The disparity in the reported prevalence of TP53 mutations at diagnosis vers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8cda56a6fb21e4b3f6d0840fd8fc815
https://doi.org/10.1182/blood-2018-99-111399
https://doi.org/10.1182/blood-2018-99-111399
Autor:
Vincent M. Isabella, Virginia L. Clark, Kenneth R. Barth, Janice M. Spence, Caroline A. Genco, Lori F. Wright, Susan Grogan
Publikováno v:
Microbiology. 154:226-239
The ability of Neisseria gonorrhoeae to reduce nitric oxide (NO) may have important immunomodulatory effects on the host during infection. Therefore, a comprehensive understanding of the regulatory mechanism of the nitric oxide reductase gene (norB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27a2cba8639e0d72c69786516818ee
https://doi.org/10.1099/mic.0.2007/010470-0
https://doi.org/10.1099/mic.0.2007/010470-0