A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

Autor: Christopher H. van Dyck, Roger Clarnette, Susan Mills, John C. Morris, Carlos Cruchaga, Anna Santacruz, Ging-Yuek Robin Hsiung, Roy Yaari, Suman Jayadev, Caroline Giacobino, William S. Brooks, Robert A. Koeppe, Raquel Sánchez-Valle, Anne M. Fagan, Eric McDade, Sarah B. Berman, Catherine J. Mummery, Florence Pasquier, Scott M. Berry, Randall J. Bateman, Brian A. Gordon, Jorge J. Llibre-Guerra, Maïté Formaglio, Paul S. Aisen, Paulo Fontoura, Mark A. Mintun, Bruno Dubois, Erik D. Roberson, Kelley Coalier, Ronald G. Thomas, Martin R. Farlow, John R. Sims, Serge Gauthier, Douglas Galasko, Mario Masellis, G. Mustafa Surti, Barbara A. Wendelberger, Guoqiao Wang, James J. Lah, Yan Li, David B. Clifford, David Wallon, Paul Delmar, Alison Goate, Rachelle S. Doody, Didier Hannequin, Stephen Salloway, Geoffrey A. Kerchner, Karen C. Holdridge, Ivonne Z. Jimenez-Velazquez, Janice M. Hitchcock, Monika Baudler, Lawrence S. Honig, Tammie L.S. Benzinger, Clifford R. Jack, Peter J. Snyder, Scott W. Andersen, J. Pariente, Andrew J. Aschenbrenner, Jason Hassenstab, Richard J. Perrin, Colin L. Masters, Chengjie Xiong, Jared R. Brosch, B. Joy Snider

Publikováno v: Nat Med

Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes decades before the onset of clinical symptoms, enabling testing of interventions in the asymptomatic and symptomatic stages to delay or slow disease progression. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b1c3c1a90789614c105385aec94852
https://doi.org/10.1038/s41591-021-01369-8

The pharmacology of latent inhibition as an animal model of schizophrenia

Autor: Paula M. Moran, Paul Moser, Janice M. Hitchcock, Sarah Lister

Publikováno v: Brain Research Reviews. 33:275-307

The nature of the primary symptoms of schizophrenia and our lack of knowledge of its underlying cause both contribute to the difficulty of generating convincing animal models of schizophrenia. A more recent approach to investigating the biological ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f3fd79a876a17570ea3fb39959684f
https://doi.org/10.1016/s0165-0173(00)00026-6

Effects of depot drug formulations in procedures used to evaluate antipsychotic activity in rodents

Autor: Joseph G. Wettstein, Janice M. Hitchcock, Stephen M. Sorensen, Sarah Lister

Publikováno v: Drug Development Research. 47:27-36

The use of long-acting depot antipsychotics results in an increase in compliance and significantly decreases rates of relapse and rehospitalization of schizophrenic patients. However, the assessment of activity of such drugs in small animals is not a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a20141b7ba9313ba45da4a90ccb305e4
https://doi.org/10.1002/(sici)1098-2299(199905)47:1<27::aid-ddr4>3.0.co

Stress-induced activation of prefrontal cortex dopamine turnover: blockade by lesions of the amygdala

Autor: Craig W. Berridge, Malcolm B. Bowers, Michael Davis, R. H. Roth, Janice M. Hitchcock, Kathleen R. Melia

Publikováno v: Brain Research. 664:207-210

Stress consistently has been found to activate peripheral and central catecholamine systems. Dopamine (DA) turnover in the prefrontal cortex is especially sensitive to stress produced by relatively mild footshock, conditioned fear, or exposure to a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec59209a2d1a6ee7130a45788e8b746
https://doi.org/10.1016/0006-8993(94)91972-0

Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm

Autor: Janice M. Hitchcock, Michael Davis

Publikováno v: Behavioral Neuroscience. 105:826-842

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1180c698b14be29d0b1151cf5d2692cb
https://doi.org/10.1037/0735-7044.105.6.826