XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks

Autor: Ronald Benjamin, Atoshi Banerjee, Xiaogang Wu, Corey Geurink, Lindsay Buczek, Danielle Eames, Sara G. Trimidal, Janice M. Pluth, Martin R. Schiller

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 2, p 593 (2022)

Double-strand breaks (DSB) are one of the most lethal forms of DNA damage that, if left unrepaired, can lead to genomic instability, cellular transformation, and cell death. In this work, we examined how repair of transcription activator-like effecto

Externí odkaz: https://doaj.org/article/713f1e38ece34dd6bf024e708606fbfd

Protons sensitize epithelial cells to mesenchymal transition.

Autor: Minli Wang, Megumi Hada, Janapriya Saha, Deepa M Sridharan, Janice M Pluth, Francis A Cucinotta

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41249 (2012)

Proton radiotherapy has gained more favor among oncologists as a treatment option for localized and deep-seated tumors. In addition, protons are a major constituent of the space radiation astronauts receive during space flights. The potential for the

Externí odkaz: https://doaj.org/article/2d7bf8c08cd148ef8b86cffca780d248

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability

Autor: Jan H.J. Hoeijmakers, Priscilla K. Cooper, Brian Shih, Ann C. Parplys, Miaw Sheue Tsai, Torsten Groesser, Kelly S. Trego, Janice M. Pluth, Ayesu Hlaing, Michael R. Nelson, Weixing Zhao, Patrick Sung, Claudia Wiese, Albert R. Davalos, Björn Rydberg, Judith Campisi

Publikováno v: Trego, K S, Groesser, T, Davalos, A R, Parplys, A C, Zhao, W, Nelson, M R, Hlaing, A, Shih, B, Rydberg, B, Pluth, J M, Tsai, M-S, Hoeijmakers, J H J, Sung, P, Wiese, C, Campisi, J & Cooper, P K 2016, ' Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability ', Molecular Cell, vol. 61, pp. 535–546 . https://doi.org/10.1016/j.molcel.2015.12.026
Molecular cell, vol 61, iss 4
Trego, KS; Groesser, T; Davalos, AR; Parplys, AC; Zhao, W; Nelson, MR; et al.(2016). Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Molecular Cell, 61(4), 535-546. doi: 10.1016/j.molcel.2015.12.026. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/2618t9h0
Molecular Cell, 61(4), 535-546. Cell Press

© 2016 Elsevier Inc. XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcfec2d212a7de1b61ea0d9e00e48d8
https://doi.org/10.1016/j.molcel.2015.12.026

Dose Response of γ Rays and Iron Nuclei for Induction of Chromosomal Aberrations in Normal and Repair-Deficient Cell Lines

Autor: Janice M. Pluth, Francis A. Cucinotta, Kerry George, Lori J. Jackson, Tetsuya Kawata, Todd Elliott, Megumi Hada

Publikováno v: Radiation Research. 171:752-763

We studied the effects of DNA double-strand break (DSB) repair deficiencies on chromosomal aberration frequency using low doses (1 Gy) of gamma rays and high-energy iron ions (LET = 151 keV/microm). Chromosomal aberrations were measured using the flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14cb5ddecb1e261e41d8a74de4f3df2
https://doi.org/10.1667/rr1680.1

Biochemical Kinetics Model of DSB Repair and Induction of γ-H2AX Foci by Non-homologous End Joining

Autor: Jennifer A. Anderson, Janice M. Pluth, Jane Harper, Francis A. Cucinotta, Peter O'Neill

Publikováno v: Radiation Research. 169:214-222

We developed a biochemical kinetics approach to describe the repair of double-strand breaks (DSBs) produced by low-LET radiation by modeling molecular events associated with non-homologous end joining (NHEJ). A system of coupled nonlinear ordinary di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26821683068e8095eed51e7f68d99b41
https://doi.org/10.1667/rr1035.1