Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Janice M, Leung"'
Autor:
Sarah Samorodnitsky, Monica Kruk, Eric F. Lock, Ken M. Kunisaki, Alison Morris, Janice M. Leung, Danielle Weise, Subina Mehta, Laurie L. Parker, Pratik D. Jagtap, Timothy J. Griffin, Chris H. Wendt
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Obstructive lung disease (OLD) is increasingly prevalent among persons living with HIV (PLWH). However, the role of proteases in HIV-associated OLD remains unclear. Methods We combined proteomics and peptidomics to comprehensively
Externí odkaz:
https://doaj.org/article/2aca99d787e348f2a5b0aec3b5cfc935
Autor:
Firoozeh V Gerayeli, Stephen Milne, Chen Xi Yang, Xuan Li, Elizabeth Guinto, Julia Shun-Wei Yang, Chung Yan Cheung, Tara R Stach, Tawimas Shaipanich, Janice M Leung, Don D Sin
Publikováno v:
BioTechniques, Vol 75, Iss 4, Pp 157-167 (2023)
Single-cell RNA sequencing (scRNA-seq) is an important tool for understanding disease pathophysiology, including airway diseases. Currently, the majority of scRNA-seq studies in airway diseases have used invasive methods (airway biopsy, surgical rese
Externí odkaz:
https://doaj.org/article/b9df64f2258148a0955035cd9a90b316
Autor:
Ana I. Hernandez Cordero, Xuan Li, Julia Yang, Chen Xi Yang, Tawimas Shaipanich, Julie L. MacIsaac, Kristy Dever, Michael S. Kobor, Julio Montaner, Marianne Harris, Silvia Guillemi, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1261 (2024)
Background: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced ep
Externí odkaz:
https://doaj.org/article/f701d3d267eb4a0f96bcf938a909d574
Autor:
Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptom
Externí odkaz:
https://doaj.org/article/3bbc99c6afb9461b8675959190300c9f
Autor:
Hyun Lee, Cara Kovacs, Andre Mattman, Zsuzsanna Hollander, Virginia Chen, Raymond Ng, Janice M. Leung, Don D. Sin
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Immunoglobulin G (IgG) deficiency increases the risk of acute exacerbations and mortality in chronic obstructive pulmonary disease (COPD). However, the impact of IgG subclass deficiency on mortality in COPD is unknown. Here, we de
Externí odkaz:
https://doaj.org/article/4d067582a96647349761a9cd6095319d
Autor:
Sarah Samorodnitsky, Eric F. Lock, Monica Kruk, Alison Morris, Janice M. Leung, Ken M. Kunisaki, Timothy J. Griffin, Chris H. Wendt
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Purpose Obstructive lung disease is increasingly common among persons with HIV, both smokers and nonsmokers. We used aptamer proteomics to identify proteins and associated pathways in HIV-associated obstructive lung disease. Methods Bronchoalveolar l
Externí odkaz:
https://doaj.org/article/b54c163bc3794e8db9c32a70dfb9ff56
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Abstract Resident microbial populations have been detected across solid tumors of diverse origins. Sequencing of the airway microbiota represents an opportunity for establishing a novel omics approach to early detection of lung cancer, as well as ris
Externí odkaz:
https://doaj.org/article/c94ad0adf9c64860bb2866ff3ad919c4
Autor:
Ana I. Hernández Cordero, Chen Xi Yang, Xuan Li, Stephen Milne, Virginia Chen, Zsuzsanna Hollander, Raymond Ng, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, John E. Connett, MeiLan K. Han, Fernando J. Martinez, Robert M. Reed, S. F. Paul Man, Janice M. Leung, Don D. Sin
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In this study we aimed t
Externí odkaz:
https://doaj.org/article/2ec17b50b24c4f93b29c56dc46e765e1
Autor:
Aniqa Shahid, Bradley R Jones, Julia S W Yang, Winnie Dong, Tawimas Shaipanich, Kathryn Donohoe, Chanson J Brumme, Jeffrey B Joy, Janice M Leung, Zabrina L Brumme
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010613 (2022)
The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral sequences (nef) by single-genome approaches from blood and lung from nine individuals on long-term suppressive antiretroviral therapy (ART), and characterized ge
Externí odkaz:
https://doaj.org/article/b8375e0e10134f47b56087abcbfb4199
Autor:
Ana I Hernández Cordero, Chen Xi Yang, Julia Yang, Xuan Li, Steve Horvath, Tawimas Shaipanich, Julia MacIsaac, David Lin, Lisa McEwen, Michael S. Kobor, Silvia Guillemi, Marianne Harris, Wan Lam, Stephen Lam, Ma'en Obeidat, Richard M. Novak, Fleur Hudson, Hartwig Klinker, Nila Dharan, Julio Montaner, S.F. Paul Man, Ken Kunisaki, Don D. Sin, Janice M. Leung, J.V. Baker, D. Duprez, A. Carr, J. Hoy, M. Dolan, A. Telenti, C. Grady, G. Matthews, J. Rockstroh, W.H. Belloso, J.M. Kagan, E. Wright, B. Brew, R.W. Price, K. Robertson, L. Cysique, K.M. Kunisaki, J.E. Connett, D.E. Niewoehner, Endpoint Review Committee, A. Lifson, R.T. Davey, Jr., J.M. Gatell, C. Pedersen, R. Prineas, J. Worley
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104206- (2022)
Summary: Background: Age-related comorbidities such as chronic obstructive pulmonary disease (COPD) are common in people living with human immunodeficiency virus (PLWH). We investigated the relationship between COPD and the epigenetic age of the airw
Externí odkaz:
https://doaj.org/article/331621657a67471ca4a7460e21dca71c