Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Janice L. Hyatt"'
Publikováno v:
Chemico-Biological Interactions. 203:226-230
Carboxylesterases (CEs) are ubiquitously expressed proteins that are responsible for the detoxification of xenobiotics. They tend to be expressed in tissues likely to be exposed to such agents (e.g., lung and gut epithelia, liver) and can hydrolyze n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f886114a347c6b9a924dad90d24b3c
https://doi.org/10.1016/j.cbi.2012.10.018
https://doi.org/10.1016/j.cbi.2012.10.018
Autor:
Bing Yan, Lyudmila Tsurkan, Janice L. Hyatt, Cynthia Jeffries, Andrew Lemoff, Carol C. Edwards, Philip M. Potter, M. Jason Hatfield
Publikováno v:
Journal of Natural Products. 76:36-44
The roots of Salvia miltiorrhiza ("Danshen") are used in traditional Chinese medicine for the treatment of numerous ailments including cardiovascular disease, hypertension, and ischemic stroke. Extracts of S. miltiorrhiza roots in the formulation "Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67d4997455df9a516e8a2603fe6cefb
https://doi.org/10.1021/np300628a
https://doi.org/10.1021/np300628a
Autor:
M. J. Hatfield, Xiaozhen Yu, Randy M. Wadkins, Philip M. Potter, Carol C. Edwards, Janice L. Hyatt, Latorya D. Hicks, Lyudmila Tsurkan
Publikováno v:
British Journal of Pharmacology. 160:1916-1928
Background and purpose: Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11. In this study, we have purified to homogeneity human liver and intestinal CEs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34c440d1a234e2abfc390c69aca2aed
https://doi.org/10.1111/j.1476-5381.2010.00700.x
https://doi.org/10.1111/j.1476-5381.2010.00700.x
Autor:
Janice L. Hyatt, Carol C. Edwards, Philip M. Potter, M. Jason Hatfield, Tad H. Koch, Benjamin L. Barthel, Renee C Torres
Publikováno v:
Journal of Medicinal Chemistry. 51:298-304
Doxazolidine (Doxaz), a formaldehyde-doxorubicin (Dox) conjugate, exhibits markedly increased tumor toxicity with respect to Dox without a concurrent increase in toxicity to cardiomyocytes. Pentyl PABC-Doxaz (PPD) is a Doxaz carbamate prodrug that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51b75014e53366c5fdd4190d972add6
https://doi.org/10.1021/jm7011479
https://doi.org/10.1021/jm7011479
Autor:
Janice L. Hyatt, Lyudmila Tsurkan, Charles R. Ross, Guy Crundwell, R. Kip Guy, Philip M. Potter, M. Jason Hatfield, Randy M. Wadkins, Stephanie A. Cantalupo, Mary K. Danks, Latorya D. Hicks, Carol C. Edwards
Publikováno v:
Journal of Medicinal Chemistry. 50:5727-5734
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of these proteins may prove useful in modulating drug half-life and bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08d60bf36bac6e900c1f9c6557cfee
https://doi.org/10.1021/jm0706867
https://doi.org/10.1021/jm0706867
Autor:
Lyudmila Tsurkan, Carol C. Edwards, Monika Wierdl, Antonio M. Ferreira, Janice L. Hyatt, Latorya D. Hicks, Teri Moak, Philip M. Potter, Randy M. Wadkins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3801-3817
We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24566ae70c789cf0fc9456498a7f9728
https://doi.org/10.1016/j.bmc.2007.03.012
https://doi.org/10.1016/j.bmc.2007.03.012
Autor:
Monika Wierdl, Carol C. Edwards, Lyudmila Tsurkan, Michael R. Taylor, Janice L. Hyatt, Robyn A. Umans, Philip M. Potter, M. Jason Hatfield
Publikováno v:
Chemico-biological interactions. 259
Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding alcohol and carboxylic acid. To date, no endogenous CE substrates have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779492846ca163151418221c274f8e7d
https://pubmed.ncbi.nlm.nih.gov/26892220
https://pubmed.ncbi.nlm.nih.gov/26892220
Autor:
Janice L. Hyatt, Matthew R. Redinbo, Randy M. Wadkins, Paul D. Jones, Carol C. Edwards, Bruce D. Hammock, Lyudmila Tsurkan, Craig E. Wheelock, Philip M. Potter
Publikováno v:
Molecular Pharmacology. 71:713-723
Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) and capecitabine and the pyrethroid insecticides. Because of the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b251206ea319218817f1c695fb774c
https://doi.org/10.1124/mol.105.021683
https://doi.org/10.1124/mol.105.021683
Autor:
Janice L. Hyatt, Carol C. Edwards, Monika Wierdl, Philip M. Potter, Lyudmila Tsurkan, Mary K. Danks
Publikováno v:
Molecular Cancer Therapeutics. 5:2281-2288
Carboxylesterases are ubiquitous proteins responsible for the detoxification of xenobiotics. However, these enzymes also activate prodrugs, such as the anticancer agents capecitabine and CPT-11. As a consequence, overexpression of carboxylesterases w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b59729292d6a7d7ecaf3dbeb297d14
https://doi.org/10.1158/1535-7163.mct-06-0160
https://doi.org/10.1158/1535-7163.mct-06-0160
Autor:
Allen D Hunter, Randy M. Wadkins, Vanessa Stacy, Kyoung Jin P. Yoon, Janice L. Hyatt, Mary K. Danks, Monika Wierdl, Guy Crundwell, Carol C. Edwards, Matthias Zeller, Philip M. Potter
Publikováno v:
Journal of Medicinal Chemistry. 48:5543-5550
Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs). Essential components of the molecule required for inhibitory activity include the dione moiety and the benzene rings, and substitution within the rings affords inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d895f8fc22ffd2c229c5c60c208cfb2e
https://doi.org/10.1021/jm0504196
https://doi.org/10.1021/jm0504196