Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Janice E Clements"'
Autor:
Natalie J. Castell, Celina M. Abreu, Erin N. Shirk, Suzanne E. Queen, Joseph L. Mankowski, Janice E. Clements, Rebecca T. Veenhuis
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114833- (2024)
Summary: Viral encephalitis is a growing public health threat with limited diagnostic and treatment options. Simian immunodeficiency virus (SIV)-infected macaques are an established model for human immunodeficiency virus (HIV), and approximately 60%
Externí odkaz:
https://doaj.org/article/af5a772730034531ac835234f852a782
Autor:
Celina M Abreu, Sarah L Price, Erin N Shirk, Rodrigo D Cunha, Luiz F Pianowski, Janice E Clements, Amilcar Tanuri, Lucio Gama
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97257 (2014)
HIV infection is not cleared by antiretroviral drugs due to the presence of latently infected cells that are not eliminated with current therapies and persist in the blood and organs of infected patients. New compounds to activate these latent reserv
Externí odkaz:
https://doaj.org/article/1507cea679ca41d098107ae84e874c04
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73849 (2013)
Fluorescence-activated cell sorting (FACS) is a sensitive and valuable technique to characterize cellular subpopulations and great advances have been made using this approach. Cells are often fixed with formaldehyde prior to the sorting process to pr
Externí odkaz:
https://doaj.org/article/c405c72eb5444ee493751c4c6997f022
Autor:
Ashwin Balagopal, Lucio Gama, Veronica Franco, Julia N Russell, Jeffrey Quinn, Yvonne Higgins, Laura M Smeaton, Janice E Clements, David L Thomas, Amita Gupta, NWCS 319 and ACTG 5175 study team
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41258 (2012)
Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from gram-negative bacteria is the principle measurement of this process. However, relate
Externí odkaz:
https://doaj.org/article/cef213256d434993a432fab2438f9653
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42801 (2012)
CCAAT/enhancer binding protein (C/EBP)β, and C/EBP binding sites in the HIV/SIV-long terminal repeat (LTR) are crucial for regulating transcription and for IFNβ-mediated suppression of virus replication in macrophages, the predominant source of pro
Externí odkaz:
https://doaj.org/article/dfb7efad5d5c48fb9b494b03f303c8ba
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22052 (2011)
CC Chemokine Ligand 2 (CCL2) is a potent chemoattractant produced by macrophages and activated astrocytes during periods of inflammation within the central nervous system. Increased CCL2 expression is correlated with disease progression and severity,
Externí odkaz:
https://doaj.org/article/42d3336cc68e4db8984058f963446bda
Autor:
Kenneth W Witwer, Lucio Gama, Ming Li, Christopher M Bartizal, Suzanne E Queen, John J Varrone, Angela K Brice, David R Graham, Patrick M Tarwater, Joseph L Mankowski, M Christine Zink, Janice E Clements
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8129 (2009)
Central nervous system (CNS) invasion during acute-stage HIV-infection has been demonstrated in a small number of individuals, but there is no evidence of neurological impairment at this stage and virus infection in brain appears to be controlled unt
Externí odkaz:
https://doaj.org/article/b6fcc0a685b1498190c37bfd65577399
Autor:
Rebecca T. Veenhuis, Celina M. Abreu, Pedro A. G. Costa, Edna A. Ferreira, Janaysha Ratliff, Lily Pohlenz, Erin N. Shirk, Leah H. Rubin, Joel N. Blankson, Lucio Gama, Janice E. Clements
Publikováno v:
Nature Microbiology. 8:833-844
The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show that H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2794716accc66644b453f0e9c205d65f
https://doi.org/10.1038/s41564-023-01349-3
https://doi.org/10.1038/s41564-023-01349-3
Publikováno v:
Pathogens and Immunity, Vol 2, Iss 2, Pp 179-198 (2017)
Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection, accumulating evidence suggests that macrophages also contribute. However, investigations of the role of macrophages are often underrepresented at HIV pathogenesi
Externí odkaz:
https://doaj.org/article/5ee103cb22744f488622c6db9bab435c
Autor:
Natalie Castell, Selena M. Guerrero-Martin, Leah H. Rubin, Erin N. Shirk, Jacqueline K. Brockhurst, Claire E. Lyons, Kevin M. Najarro, Suzanne E. Queen, Bess W. Carlson, Robert J. Adams, Craig N. Morrell, Lucio Gama, David R. Graham, Christine Zink, Joseph L. Mankowski, Janice E. Clements, Kelly A. Metcalf Pate
Publikováno v:
Psychosomatic medicine. 84(8)
Simian immunodeficiency virus (SIV) infection of macaques recapitulates many aspects of HIV pathogenesis and is similarly affected by both genetic and environmental factors. Psychosocial stress is associated with immune system dysregulation and worse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e4e129d2feb63f7cbd801893b8bac2
https://pubmed.ncbi.nlm.nih.gov/36162063
https://pubmed.ncbi.nlm.nih.gov/36162063