Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Janice E Clements"'
Autor:
Natalie J. Castell, Celina M. Abreu, Erin N. Shirk, Suzanne E. Queen, Joseph L. Mankowski, Janice E. Clements, Rebecca T. Veenhuis
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114833- (2024)
Summary: Viral encephalitis is a growing public health threat with limited diagnostic and treatment options. Simian immunodeficiency virus (SIV)-infected macaques are an established model for human immunodeficiency virus (HIV), and approximately 60%
Externí odkaz:
https://doaj.org/article/af5a772730034531ac835234f852a782
Autor:
Rebecca T. Veenhuis, Dionna W. Williams, Erin N. Shirk, Celina M. Abreu, Edna A. Ferreira, Jennifer M. Coughlin, Todd T. Brown, Pauline M. Maki, Kathryn Anastos, Joan W. Berman, Janice E. Clements, Leah H. Rubin
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
BACKGROUND Identifying a quantitative biomarker of neuropsychiatric dysfunction in people with HIV (PWH) remains a significant challenge in the neuroHIV field. The strongest evidence to date implicates the role of monocytes in central nervous system
Externí odkaz:
https://doaj.org/article/d4c51297b11e4dc0a27832462d3f699a
Autor:
Rebecca T. Veenhuis, Celina M. Abreu, Pedro A. G. Costa, Edna A. Ferreira, Janaysha Ratliff, Lily Pohlenz, Erin N. Shirk, Leah H. Rubin, Joel N. Blankson, Lucio Gama, Janice E. Clements
Publikováno v:
Nature Microbiology. 8:833-844
The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show that H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2794716accc66644b453f0e9c205d65f
https://doi.org/10.1038/s41564-023-01349-3
https://doi.org/10.1038/s41564-023-01349-3
Publikováno v:
Pathogens and Immunity, Vol 2, Iss 2, Pp 179-198 (2017)
Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection, accumulating evidence suggests that macrophages also contribute. However, investigations of the role of macrophages are often underrepresented at HIV pathogenesi
Externí odkaz:
https://doaj.org/article/5ee103cb22744f488622c6db9bab435c
Autor:
Celina M. Abreu, Rebecca T. Veenhuis, Claudia R. Avalos, Shelby Graham, Daymond R. Parrilla, Edna A. Ferreira, Suzanne E. Queen, Erin N. Shirk, Brandon T. Bullock, Ming Li, Kelly A. Metcalf Pate, Sarah E. Beck, Lisa M. Mangus, Joseph L. Mankowski, Feilim Mac Gabhann, Shelby L. O’Connor, Lucio Gama, Janice E. Clements
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could contribute to viral rebound after ART interruption. CD4 T cel
Externí odkaz:
https://doaj.org/article/bcbb18ba10ce487f8c86493a4d42ad7b
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT HIV reservoirs persist despite antiretroviral therapy (ART) and are established within a few days after infection. Infected myeloid cells in the central nervous system (CNS) may contribute to the establishment of a CNS viral reservoir. The m
Externí odkaz:
https://doaj.org/article/8981c6ce8a9c42c997d3b35fb6bf5e49
Autor:
Claudia R. Avalos, Celina M. Abreu, Suzanne E. Queen, Ming Li, Sarah Price, Erin N. Shirk, Elizabeth L. Engle, Ellen Forsyth, Brandon T. Bullock, Feilim Mac Gabhann, Stephen W. Wietgrefe, Ashley T. Haase, M. Christine Zink, Joseph L. Mankowski, Janice E. Clements, Lucio Gama
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT A human immunodeficiency virus (HIV) infection cure requires an understanding of the cellular and anatomical sites harboring virus that contribute to viral rebound upon treatment interruption. Despite antiretroviral therapy (ART), HIV-associ
Externí odkaz:
https://doaj.org/article/cc2e12c107704e4d86a6f1bc8f4383ea
Autor:
Natalie Castell, Selena M. Guerrero-Martin, Leah H. Rubin, Erin N. Shirk, Jacqueline K. Brockhurst, Claire E. Lyons, Kevin M. Najarro, Suzanne E. Queen, Bess W. Carlson, Robert J. Adams, Craig N. Morrell, Lucio Gama, David R. Graham, Christine Zink, Joseph L. Mankowski, Janice E. Clements, Kelly A. Metcalf Pate
Publikováno v:
Psychosomatic medicine. 84(8)
Simian immunodeficiency virus (SIV) infection of macaques recapitulates many aspects of HIV pathogenesis and is similarly affected by both genetic and environmental factors. Psychosocial stress is associated with immune system dysregulation and worse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e4e129d2feb63f7cbd801893b8bac2
https://pubmed.ncbi.nlm.nih.gov/36162063
https://pubmed.ncbi.nlm.nih.gov/36162063
Autor:
Maribel Donoso, Anna Maria Gorska, Eliana Scemes, Silvana Valdebenito, Janice E. Clements, Brendan Prideaux, Suzanne E. Queen, Eliseo A. Eugenin
Publikováno v:
Journal of Neurochemistry. 158:500-521
In healthy conditions, pannexin-1 (Panx-1) channels are in a close state, but in several pathological conditions, including HIV and NeuroHIV, the channel becomes open. However, the mechanism or contribution of Panx-1 channels to the Human Immunodefic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc957dc77b66b29af08e2b69f828e78
https://doi.org/10.1111/jnc.15374
https://doi.org/10.1111/jnc.15374
Publikováno v:
Viruses, Vol 4, Iss 10, Pp 1844-1864 (2012)
Long-lived HIV-1 reservoirs include tissue macrophages. Monocyte-derived macrophages are more susceptible to infection and more permissive to HIV-1 replication than monocytes for reasons that may include the effects of different populations of miRNAs
Externí odkaz:
https://doaj.org/article/ab9f3dda1d644d75895813c9c970401c